STRINGSTRING
ENSUAMP00000000600 ENSUAMP00000000600 BMPR2 BMPR2 BMPR1A BMPR1A NOTCH1 NOTCH1 SAV1 SAV1 SLIT3 SLIT3 BMP4 BMP4 SMAD7 SMAD7 CITED2 CITED2 GJA5 GJA5 ZFPM2 ZFPM2 SMAD4 SMAD4 ENSUAMP00000017830 ENSUAMP00000017830 TGFBR1 TGFBR1 APLNR APLNR HES1 HES1 NSD2 NSD2 NKX2-5 NKX2-5 WNT11 WNT11 PROX1 PROX1 FZD2 FZD2 NOG NOG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000000600Uncharacterized protein. (130 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NOTCH1Notch receptor 1. (2547 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
SLIT3Slit guidance ligand 3. (1441 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1193 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1344 aa)
NKX2-5NK2 homeobox 5. (323 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PROX1Prospero homeobox 1. (737 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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