18 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	ESR1	Estrogen receptor 1. (490 aa)
	ENSUAMP00000013585	Uncharacterized protein. (588 aa)
	AREG	Amphiregulin. (257 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	EPHA2	EPH receptor A2. (966 aa)
	ENSUAMP00000021186	Uncharacterized protein. (404 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	ENSUAMP00000027148	Uncharacterized protein. (221 aa)
	CSF1	Colony stimulating factor 1. (518 aa)
	SRC	Tyrosine-protein kinase. (557 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	KDM5B	Lysine demethylase 5B. (1039 aa)
	PML	Promyelocytic leukemia. (877 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
	DDR1	Discoidin domain receptor tyrosine kinase 1. (936 aa)
	VDR	Vitamin D receptor. (427 aa)
	PHB2	Prohibitin. (297 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	EPHA2	ENSUAMP00000016267	ENSUAMP00000018573	Amphiregulin.	EPH receptor A2.	0.909
AREG	ESR1	ENSUAMP00000016267	ENSUAMP00000006270	Amphiregulin.	Estrogen receptor 1.	0.435
AREG	SRC	ENSUAMP00000016267	ENSUAMP00000030149	Amphiregulin.	Tyrosine-protein kinase.	0.684
CSF1	EPHA2	ENSUAMP00000028977	ENSUAMP00000018573	Colony stimulating factor 1.	EPH receptor A2.	0.914
CSF1	SRC	ENSUAMP00000028977	ENSUAMP00000030149	Colony stimulating factor 1.	Tyrosine-protein kinase.	0.648
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000013585	KDM5B	ENSUAMP00000013585	ENSUAMP00000032768	Uncharacterized protein.	Lysine demethylase 5B.	0.927
ENSUAMP00000013585	MED1	ENSUAMP00000013585	ENSUAMP00000034047	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.427
ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000021186	ENSUAMP00000027148	ENSUAMP00000021186	ENSUAMP00000027148	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSUAMP00000027148	ENSUAMP00000021186	ENSUAMP00000027148	ENSUAMP00000021186	Uncharacterized protein.	Uncharacterized protein.	0.899
EPHA2	AREG	ENSUAMP00000018573	ENSUAMP00000016267	EPH receptor A2.	Amphiregulin.	0.909
EPHA2	CSF1	ENSUAMP00000018573	ENSUAMP00000028977	EPH receptor A2.	Colony stimulating factor 1.	0.914
ESR1	AREG	ENSUAMP00000006270	ENSUAMP00000016267	Estrogen receptor 1.	Amphiregulin.	0.435
ESR1	MED1	ENSUAMP00000006270	ENSUAMP00000034047	Estrogen receptor 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.987
ESR1	PHB2	ENSUAMP00000006270	ENSUAMP00000035498	Estrogen receptor 1.	Prohibitin.	0.796
ESR1	SRC	ENSUAMP00000006270	ENSUAMP00000030149	Estrogen receptor 1.	Tyrosine-protein kinase.	0.995
KDM5B	ENSUAMP00000013585	ENSUAMP00000032768	ENSUAMP00000013585	Lysine demethylase 5B.	Uncharacterized protein.	0.927
KDM5B	MED1	ENSUAMP00000032768	ENSUAMP00000034047	Lysine demethylase 5B.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.427
LRP5	SRC	ENSUAMP00000025455	ENSUAMP00000030149	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Tyrosine-protein kinase.	0.516