STRINGSTRING
RBCK1 RBCK1 RIPK1 RIPK1 ARHGEF2 ARHGEF2 YBX3 YBX3 ENSUAMP00000022576 ENSUAMP00000022576 ZBP1 ZBP1 PELI1 PELI1 FADD FADD CYLD CYLD SPATA2 SPATA2 CASP6 CASP6 RIPK3 RIPK3 BOK BOK CAV1 CAV1 CASP8 CASP8 CASP10 CASP10 ENSUAMP00000007992 ENSUAMP00000007992 BIRC3 BIRC3 ENSUAMP00000031321 ENSUAMP00000031321 BIRC2 BIRC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (526 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1188 aa)
YBX3Y-box binding protein 3. (273 aa)
ENSUAMP00000022576Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (541 aa)
ZBP1Z-DNA binding protein 1. (445 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (451 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (481 aa)
ENSUAMP00000007992Uncharacterized protein. (219 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
ENSUAMP00000031321Uncharacterized protein. (1080 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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