STRINGSTRING
ARHGEF2 ARHGEF2 RBCK1 RBCK1 CASP10 CASP10 CASP8 CASP8 CAV1 CAV1 BOK BOK BIRC3 BIRC3 BIRC2 BIRC2 ENSUAMP00000031321 ENSUAMP00000031321 FADD FADD PELI1 PELI1 ENSUAMP00000022576 ENSUAMP00000022576 YBX3 YBX3 RIPK1 RIPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1188 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (526 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
ENSUAMP00000031321Uncharacterized protein. (1080 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ENSUAMP00000022576Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (541 aa)
YBX3Y-box binding protein 3. (273 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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