12 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	LRP2	LDL receptor related protein 2. (4684 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
	FOXH1	Forkhead box H1. (370 aa)
	ENSUAMP00000005691	LEM domain-containing protein. (179 aa)
	ENSUAMP00000005686	MSC domain-containing protein. (201 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	AXIN2	Axin 2. (843 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSUAMP00000001279	ENSUAMP00000028868	Axin 2.	Bone morphogenetic protein 4.	0.535
AXIN2	LRP2	ENSUAMP00000001279	ENSUAMP00000024677	Axin 2.	LDL receptor related protein 2.	0.482
AXIN2	WNT11	ENSUAMP00000001279	ENSUAMP00000002348	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.627
BMP4	AXIN2	ENSUAMP00000028868	ENSUAMP00000001279	Bone morphogenetic protein 4.	Axin 2.	0.535
BMP4	BMPR1A	ENSUAMP00000028868	ENSUAMP00000036181	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	FOXH1	ENSUAMP00000028868	ENSUAMP00000007591	Bone morphogenetic protein 4.	Forkhead box H1.	0.404
BMP4	MEF2C	ENSUAMP00000028868	ENSUAMP00000029640	Bone morphogenetic protein 4.	Myocyte enhancer factor 2C.	0.418
BMP4	WNT11	ENSUAMP00000028868	ENSUAMP00000002348	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.442
BMPR1A	BMP4	ENSUAMP00000036181	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
ENSUAMP00000005686	ENSUAMP00000005691	ENSUAMP00000005686	ENSUAMP00000005691	MSC domain-containing protein.	LEM domain-containing protein.	0.895
ENSUAMP00000005691	ENSUAMP00000005686	ENSUAMP00000005691	ENSUAMP00000005686	LEM domain-containing protein.	MSC domain-containing protein.	0.895
FOXH1	BMP4	ENSUAMP00000007591	ENSUAMP00000028868	Forkhead box H1.	Bone morphogenetic protein 4.	0.404
LRP2	AXIN2	ENSUAMP00000024677	ENSUAMP00000001279	LDL receptor related protein 2.	Axin 2.	0.482
MEF2C	BMP4	ENSUAMP00000029640	ENSUAMP00000028868	Myocyte enhancer factor 2C.	Bone morphogenetic protein 4.	0.418
WNT11	AXIN2	ENSUAMP00000002348	ENSUAMP00000001279	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Axin 2.	0.627
WNT11	BMP4	ENSUAMP00000002348	ENSUAMP00000028868	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Bone morphogenetic protein 4.	0.442