32 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	ENSUAMP00000037141	Uncharacterized protein. (54 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2520 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1100 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMAD6	Mothers against decapentaplegic homolog. (484 aa)
	LRP2	LDL receptor related protein 2. (4684 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
	ENSUAMP00000021593	Uncharacterized protein. (76 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	SRF	Serum response factor. (507 aa)
	VEGFB	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (191 aa)
	ENSUAMP00000018722	Uncharacterized protein. (423 aa)
	ENSUAMP00000018719	Uncharacterized protein. (538 aa)
	MMP21	Matrix metallopeptidase 21. (422 aa)
	ENSUAMP00000003003	Plexin_cytopl domain-containing protein. (490 aa)
	CPLANE1	Uncharacterized protein. (2067 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (445 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
	DCTN5	Dynactin subunit 5. (167 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (832 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (927 aa)
	ENSUAMP00000010093	SUFU_C domain-containing protein. (81 aa)
	ZBTB14	Zinc finger and BTB domain containing 14. (449 aa)
	MEGF8	Multiple EGF like domains 8. (2820 aa)
	PRDM1	PR/SET domain 1. (846 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	ENSUAMP00000015680	Uncharacterized protein. (92 aa)
	ARID2	AT-rich interaction domain 2. (1776 aa)
	APLN	Apelin. (71 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLN	APLNR	ENSUAMP00000017750	ENSUAMP00000014445	Apelin.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.992
APLN	ENSUAMP00000037141	ENSUAMP00000017750	ENSUAMP00000037141	Apelin.	Uncharacterized protein.	0.450
APLNR	APLN	ENSUAMP00000014445	ENSUAMP00000017750	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Apelin.	0.992
APLNR	ENSUAMP00000037141	ENSUAMP00000014445	ENSUAMP00000037141	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.896
BMP4	GPC3	ENSUAMP00000028868	ENSUAMP00000021714	Bone morphogenetic protein 4.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.429
BMP4	HAND2	ENSUAMP00000028868	ENSUAMP00000007457	Bone morphogenetic protein 4.	Heart and neural crest derivatives expressed 2.	0.505
BMP4	NOTCH1	ENSUAMP00000028868	ENSUAMP00000034225	Bone morphogenetic protein 4.	Notch receptor 1.	0.426
BMP4	SMAD6	ENSUAMP00000028868	ENSUAMP00000026564	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.741
BMP4	TGFBR1	ENSUAMP00000028868	ENSUAMP00000016865	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.807
CPLANE1	ENSUAMP00000018719	ENSUAMP00000003419	ENSUAMP00000018719	Uncharacterized protein.	Uncharacterized protein.	0.868
CPLANE1	ENSUAMP00000018722	ENSUAMP00000003419	ENSUAMP00000018722	Uncharacterized protein.	Uncharacterized protein.	0.879
ENSUAMP00000018719	CPLANE1	ENSUAMP00000018719	ENSUAMP00000003419	Uncharacterized protein.	Uncharacterized protein.	0.868
ENSUAMP00000018719	ENSUAMP00000018722	ENSUAMP00000018719	ENSUAMP00000018722	Uncharacterized protein.	Uncharacterized protein.	0.866
ENSUAMP00000018722	CPLANE1	ENSUAMP00000018722	ENSUAMP00000003419	Uncharacterized protein.	Uncharacterized protein.	0.879
ENSUAMP00000018722	ENSUAMP00000018719	ENSUAMP00000018722	ENSUAMP00000018719	Uncharacterized protein.	Uncharacterized protein.	0.866
ENSUAMP00000037141	APLN	ENSUAMP00000037141	ENSUAMP00000017750	Uncharacterized protein.	Apelin.	0.450
ENSUAMP00000037141	APLNR	ENSUAMP00000037141	ENSUAMP00000014445	Uncharacterized protein.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.896
GPC3	BMP4	ENSUAMP00000021714	ENSUAMP00000028868	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Bone morphogenetic protein 4.	0.429
HAND2	BMP4	ENSUAMP00000007457	ENSUAMP00000028868	Heart and neural crest derivatives expressed 2.	Bone morphogenetic protein 4.	0.505
NOTCH1	BMP4	ENSUAMP00000034225	ENSUAMP00000028868	Notch receptor 1.	Bone morphogenetic protein 4.	0.426