44 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VDR	Vitamin D receptor. (427 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	MSX1	Msh homeobox 1. (303 aa)
	ENSUAMP00000003081	Uncharacterized protein. (413 aa)
	LRRC1	Leucine rich repeat containing 1. (435 aa)
	ATP2C2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (931 aa)
	ESR1	Estrogen receptor 1. (490 aa)
	LATS1	Uncharacterized protein. (1012 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (305 aa)
	PTCH1	Patched 1. (1453 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	ENSUAMP00000013585	Uncharacterized protein. (588 aa)
	FOXF1	Forkhead box F1. (379 aa)
	AREG	Amphiregulin. (257 aa)
	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (733 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1630 aa)
	SOSTDC1	Sclerostin domain containing 1. (206 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	HOXA5	Homeobox A5. (381 aa)
	EPHA2	EPH receptor A2. (966 aa)
	IRF6	Interferon regulatory factor 6. (462 aa)
	ENSUAMP00000021186	Uncharacterized protein. (404 aa)
	ENSUAMP00000023517	Laminin N-terminal domain-containing protein. (378 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	ENSUAMP00000027148	Uncharacterized protein. (221 aa)
	CEBPB	CCAAT/enhancer-binding protein. (346 aa)
	STAT6	Signal transducer and activator of transcription. (844 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	CSF1	Colony stimulating factor 1. (518 aa)
	ENSUAMP00000029322	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	SRC	Tyrosine-protein kinase. (557 aa)
	ZNF703	Zinc finger protein 703. (592 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	KDM5B	Lysine demethylase 5B. (1039 aa)
	ENSUAMP00000033009	Uncharacterized protein. (1337 aa)
	PML	Promyelocytic leukemia. (877 aa)
	FOXB1	Forkhead box B1. (325 aa)
	PHB2	Prohibitin. (297 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
	DDR1	Discoidin domain receptor tyrosine kinase 1. (936 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (823 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP2	ENSUAMP00000003081	ENSUAMP00000016525	ENSUAMP00000003081	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	Uncharacterized protein.	0.899
AREG	EPHA2	ENSUAMP00000016267	ENSUAMP00000018573	Amphiregulin.	EPH receptor A2.	0.909
AREG	ESR1	ENSUAMP00000016267	ENSUAMP00000006270	Amphiregulin.	Estrogen receptor 1.	0.435
AREG	SRC	ENSUAMP00000016267	ENSUAMP00000030149	Amphiregulin.	Tyrosine-protein kinase.	0.684
CEBPB	ESR1	ENSUAMP00000027268	ENSUAMP00000006270	CCAAT/enhancer-binding protein.	Estrogen receptor 1.	0.645
CEBPB	MAPK1	ENSUAMP00000027268	ENSUAMP00000013584	CCAAT/enhancer-binding protein.	Mitogen-activated protein kinase.	0.896
CEBPB	STAT6	ENSUAMP00000027268	ENSUAMP00000027363	CCAAT/enhancer-binding protein.	Signal transducer and activator of transcription.	0.448
CSF1	ENSUAMP00000029322	ENSUAMP00000028977	ENSUAMP00000029322	Colony stimulating factor 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.439
CSF1	EPHA2	ENSUAMP00000028977	ENSUAMP00000018573	Colony stimulating factor 1.	EPH receptor A2.	0.914
CSF1	SRC	ENSUAMP00000028977	ENSUAMP00000030149	Colony stimulating factor 1.	Tyrosine-protein kinase.	0.648
CSF1	STAT6	ENSUAMP00000028977	ENSUAMP00000027363	Colony stimulating factor 1.	Signal transducer and activator of transcription.	0.498
CSF1	TNFSF11	ENSUAMP00000028977	ENSUAMP00000006985	Colony stimulating factor 1.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.420
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000000600	MAPK1	ENSUAMP00000000600	ENSUAMP00000013584	Uncharacterized protein.	Mitogen-activated protein kinase.	0.876
ENSUAMP00000003081	AGAP2	ENSUAMP00000003081	ENSUAMP00000016525	Uncharacterized protein.	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	0.899
ENSUAMP00000013585	KDM5B	ENSUAMP00000013585	ENSUAMP00000032768	Uncharacterized protein.	Lysine demethylase 5B.	0.927
ENSUAMP00000013585	MED1	ENSUAMP00000013585	ENSUAMP00000034047	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.427
ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000017830	MAPK1	ENSUAMP00000017830	ENSUAMP00000013584	Uncharacterized protein.	Mitogen-activated protein kinase.	0.875
ENSUAMP00000021186	ENSUAMP00000027148	ENSUAMP00000021186	ENSUAMP00000027148	Uncharacterized protein.	Uncharacterized protein.	0.899