(11 nodes) Cell surface receptor signaling pathway involved in heart development network (Ursus americanus)

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second shell of interactors

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Predicted Interactions

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Your Input:
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
	MKS1	MKS transition zone complex subunit 1. (689 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	MSX1	Msh homeobox 1. (303 aa)
	SNAI1	Snail family transcriptional repressor 1. (259 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
	NOTCH1	Notch receptor 1. (2547 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSUAMP00000021596	ENSUAMP00000028868	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.943
BMP2	BMPR1A	ENSUAMP00000021596	ENSUAMP00000036181	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
BMP2	NOG	ENSUAMP00000021596	ENSUAMP00000001684	Bone morphogenetic protein 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.990
BMP4	BMP2	ENSUAMP00000028868	ENSUAMP00000021596	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.943
BMP4	BMPR1A	ENSUAMP00000028868	ENSUAMP00000036181	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	JAG1	ENSUAMP00000028868	ENSUAMP00000034607	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.656
BMP4	MSX1	ENSUAMP00000028868	ENSUAMP00000000613	Bone morphogenetic protein 4.	Msh homeobox 1.	0.628
BMP4	NOG	ENSUAMP00000028868	ENSUAMP00000001684	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.996
BMP4	NOTCH1	ENSUAMP00000028868	ENSUAMP00000034225	Bone morphogenetic protein 4.	Notch receptor 1.	0.426
BMPR1A	BMP2	ENSUAMP00000036181	ENSUAMP00000021596	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 2.	0.999
BMPR1A	BMP4	ENSUAMP00000036181	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
BMPR1A	MSX1	ENSUAMP00000036181	ENSUAMP00000000613	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Msh homeobox 1.	0.636
BMPR1A	NOG	ENSUAMP00000036181	ENSUAMP00000001684	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.700
DLL4	JAG1	ENSUAMP00000021107	ENSUAMP00000034607	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.466
DLL4	NOTCH1	ENSUAMP00000021107	ENSUAMP00000034225	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.997
JAG1	BMP4	ENSUAMP00000034607	ENSUAMP00000028868	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Bone morphogenetic protein 4.	0.656
JAG1	DLL4	ENSUAMP00000034607	ENSUAMP00000021107	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.466
JAG1	NOG	ENSUAMP00000034607	ENSUAMP00000001684	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.634
JAG1	NOTCH1	ENSUAMP00000034607	ENSUAMP00000034225	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.997
MSX1	BMP4	ENSUAMP00000000613	ENSUAMP00000028868	Msh homeobox 1.	Bone morphogenetic protein 4.	0.628