STRINGSTRING
HOXA5 HOXA5 EGR1 EGR1 MSX1 MSX1 ENSUAMP00000000756 ENSUAMP00000000756 EPYC EPYC ARID5B ARID5B ENSUAMP00000001245 ENSUAMP00000001245 AXIN2 AXIN2 SCUBE2 SCUBE2 ITGB8 ITGB8 NOG NOG DYRK1B DYRK1B PAXIP1 PAXIP1 ZEB1 ZEB1 SPART SPART ENSUAMP00000003016 ENSUAMP00000003016 ENSUAMP00000003418 ENSUAMP00000003418 RARG RARG ENSUAMP00000004452 ENSUAMP00000004452 ENSUAMP00000004460 ENSUAMP00000004460 SERPINH1 SERPINH1 FGF9 FGF9 PDGFB PDGFB TWSG1 TWSG1 SLC39A13 SLC39A13 FGF6 FGF6 ENSUAMP00000006989 ENSUAMP00000006989 EXT2 EXT2 NPPC NPPC COL3A1 COL3A1 HAND2 HAND2 WNT2B WNT2B LOX LOX OTOR OTOR MMP13 MMP13 PIK3CA PIK3CA DLX2 DLX2 ENSUAMP00000009377 ENSUAMP00000009377 GDF5 GDF5 ENSUAMP00000009764 ENSUAMP00000009764 ATF2 ATF2 ENSUAMP00000010225 ENSUAMP00000010225 CYTL1 CYTL1 PUM2 PUM2 HOXB3 HOXB3 CHRDL2 CHRDL2 CCN3 CCN3 CCN2 CCN2 SLC25A25 SLC25A25 SELENOM SELENOM TGFB1 TGFB1 ENSUAMP00000012599 ENSUAMP00000012599 DDRGK1 DDRGK1 ZBTB16 ZBTB16 RARB RARB EXT1 EXT1 ARRDC3 ARRDC3 ENSUAMP00000014408 ENSUAMP00000014408 FOXA1 FOXA1 RB1 RB1 ENSUAMP00000015788 ENSUAMP00000015788 ENSUAMP00000015842 ENSUAMP00000015842 SOX8 SOX8 MEF2D MEF2D ENSUAMP00000017173 ENSUAMP00000017173 OGN OGN SLC39A14 SLC39A14 MEX3C MEX3C PPARD PPARD HOXA3 HOXA3 HOXA11 HOXA11 PBXIP1 PBXIP1 ECM1 ECM1 MKKS MKKS ENSUAMP00000018782 ENSUAMP00000018782 ENSUAMP00000019308 ENSUAMP00000019308 ENSUAMP00000019709 ENSUAMP00000019709 SRF SRF SMPD3 SMPD3 ENSUAMP00000020386 ENSUAMP00000020386 DHRS7B DHRS7B RUNX1 RUNX1 BBS2 BBS2 BMP2 BMP2 MYF5 MYF5 SMAD5 SMAD5 AMER1 AMER1 TAPT1 TAPT1 PITX1 PITX1 CCN1 CCN1 MATN1 MATN1 ENSUAMP00000023668 ENSUAMP00000023668 ARID5A ARID5A GPLD1 GPLD1 IL17F IL17F HAND1 HAND1 SULF2 SULF2 SNORC SNORC LRP5 LRP5 ENSUAMP00000025690 ENSUAMP00000025690 ENSUAMP00000025721 ENSUAMP00000025721 SOX9 SOX9 THBS3 THBS3 IMPAD1 IMPAD1 LTBP3 LTBP3 OSR2 OSR2 PPARGC1A PPARGC1A CNMD CNMD SULF1 SULF1 ENSUAMP00000027842 ENSUAMP00000027842 ENSUAMP00000027843 ENSUAMP00000027843 ENSUAMP00000027942 ENSUAMP00000027942 VPS13B VPS13B BMP4 BMP4 CSF1 CSF1 SPTLC2 SPTLC2 ENSUAMP00000029322 ENSUAMP00000029322 MEF2C MEF2C CER1 CER1 ZNF516 ZNF516 ENSUAMP00000030105 ENSUAMP00000030105 EDN1 EDN1 ANXA6 ANXA6 FGF18 FGF18 MAPK3 MAPK3 GLI3 GLI3 FGF4 FGF4 ENSUAMP00000032843 ENSUAMP00000032843 BMPR1B BMPR1B BMP3 BMP3 PTH1R PTH1R BBS4 BBS4 HOXD3 HOXD3 RXFP1 RXFP1 RASAL2 RASAL2 NOTCH1 NOTCH1 HIF1A HIF1A HOXC4 HOXC4 OSR1 OSR1 SNAI1 SNAI1 WNT10B WNT10B IFT80 IFT80 BMPR1A BMPR1A ZMPSTE24 ZMPSTE24 BGN BGN COMP COMP TRPV4 TRPV4 BMPR2 BMPR2 TRIP11 TRIP11 SATB2 SATB2 HYAL2 HYAL2 HYAL1 HYAL1 HYAL3 HYAL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXA5Homeobox A5. (381 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
MSX1Msh homeobox 1. (303 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
EPYCEpiphycan. (319 aa)
ARID5BAT-rich interaction domain 5B. (1188 aa)
ENSUAMP00000001245CTF/NF-I domain-containing protein. (195 aa)
AXIN2Axin 2. (843 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1071 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (614 aa)
PAXIP1PAX interacting protein 1. (1017 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1017 aa)
SPARTSpartin. (672 aa)
ENSUAMP00000003016Uncharacterized protein. (461 aa)
ENSUAMP00000003418VWFA domain-containing protein. (258 aa)
RARGRetinoic acid receptor gamma. (458 aa)
ENSUAMP00000004452annotation not available (461 aa)
ENSUAMP00000004460Runt domain-containing protein. (278 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (449 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
SLC39A13Solute carrier family 39 member 13. (454 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
ENSUAMP00000006989CTF/NF-I domain-containing protein. (213 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (673 aa)
NPPCNatriuretic peptide C. (126 aa)
COL3A1Collagen type III alpha 1 chain. (997 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
LOXLysyl oxidase. (414 aa)
OTOROtoraplin. (129 aa)
MMP13Matrix metallopeptidase 13. (484 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DLX2Distal-less homeobox 2. (333 aa)
ENSUAMP00000009377Uncharacterized protein. (170 aa)
GDF5Growth differentiation factor 5. (499 aa)
ENSUAMP00000009764Uncharacterized protein. (496 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSUAMP00000010225Uncharacterized protein. (96 aa)
CYTL1Cytokine like 1. (135 aa)
PUM2Pumilio RNA binding family member 2. (851 aa)
HOXB3Homeobox B3. (254 aa)
CHRDL2Chordin like 2. (397 aa)
CCN3Cellular communication network factor 3. (353 aa)
CCN2Cellular communication network factor 2. (349 aa)
SLC25A25Solute carrier family 25 member 25; Belongs to the mitochondrial carrier (TC 2.A.29) family. (469 aa)
SELENOMSelenoprotein M. (140 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENSUAMP00000012599Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (573 aa)
DDRGK1DDRGK domain containing 1. (344 aa)
ZBTB16Zinc finger and BTB domain containing 16. (423 aa)
RARBRetinoic acid receptor beta. (336 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
ARRDC3Arrestin domain containing 3. (414 aa)
ENSUAMP00000014408RunxI domain-containing protein. (143 aa)
FOXA1Forkhead box A1. (472 aa)
RB1RB transcriptional corepressor 1. (870 aa)
ENSUAMP00000015788BZIP domain-containing protein. (359 aa)
ENSUAMP00000015842Uncharacterized protein. (82 aa)
SOX8SRY-box transcription factor 8. (449 aa)
MEF2DMyocyte enhancer factor 2D. (515 aa)
ENSUAMP00000017173Nexin_C domain-containing protein. (161 aa)
OGNOsteoglycin. (297 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
MEX3CMex-3 RNA binding family member C. (496 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
HOXA3Homeobox A3. (419 aa)
HOXA11Homeobox A11. (313 aa)
PBXIP1PBX homeobox interacting protein 1. (707 aa)
ECM1Extracellular matrix protein 1. (422 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
ENSUAMP00000018782BBS1 domain-containing protein. (623 aa)
ENSUAMP00000019308Uncharacterized protein. (459 aa)
ENSUAMP00000019709Uncharacterized protein. (915 aa)
SRFSerum response factor. (507 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
ENSUAMP00000020386Uncharacterized protein. (460 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (324 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (444 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
AMER1APC membrane recruitment protein 1. (1132 aa)
TAPT1Transmembrane anterior posterior transformation 1. (529 aa)
PITX1Homeobox protein. (313 aa)
CCN1Cellular communication network factor 1. (382 aa)
MATN1Matrilin 1. (497 aa)
ENSUAMP00000023668Uncharacterized protein. (113 aa)
ARID5AAT-rich interaction domain 5A. (437 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (726 aa)
IL17FInterleukin 17F. (156 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
SNORCSecondary ossification center associated regulator of chondrocyte maturation. (124 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ENSUAMP00000025690Runt domain-containing protein. (196 aa)
ENSUAMP00000025721Uncharacterized protein. (113 aa)
SOX9SRY-box transcription factor 9. (484 aa)
THBS3Thrombospondin 3. (1000 aa)
IMPAD1Inositol monophosphatase domain containing 1. (360 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1169 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
PPARGC1APPARG coactivator 1 alpha. (761 aa)
CNMDChondromodulin. (340 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (940 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
ENSUAMP00000027942Link domain-containing protein. (477 aa)
VPS13BVacuolar protein sorting 13 homolog B. (2858 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CSF1Colony stimulating factor 1. (518 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (561 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CER1Cerberus 1, DAN family BMP antagonist. (279 aa)
ZNF516Zinc finger protein 516. (1142 aa)
ENSUAMP00000030105Uncharacterized protein. (165 aa)
EDN1Endothelin 1. (202 aa)
ANXA6Annexin. (673 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
GLI3GLI family zinc finger 3. (1413 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (594 aa)
BBS4Uncharacterized protein. (384 aa)
HOXD3Homeobox D3. (432 aa)
RXFP1Relaxin family peptide receptor 1. (724 aa)
RASAL2RAS protein activator like 2. (1287 aa)
NOTCH1Notch receptor 1. (2547 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
HOXC4Homeobox C4. (264 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
SNAI1Snail family transcriptional repressor 1. (259 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
IFT80Intraflagellar transport 80. (768 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (369 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (861 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
TRIP11Thyroid hormone receptor interactor 11. (1978 aa)
SATB2DNA-binding protein SATB. (733 aa)
HYAL2Hyaluronidase. (472 aa)
HYAL1Hyaluronidase. (435 aa)
HYAL3Hyaluronidase. (417 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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