78 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC27A4	Solute carrier family 27 member 4. (645 aa)
	ACMSD	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (527 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	C1QTNF12	C1q and TNF related 12. (309 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ENSUAMP00000002362	Uncharacterized protein. (354 aa)
	WDTC1	WD and tetratricopeptide repeats 1. (679 aa)
	ENSUAMP00000002699	C1q domain-containing protein. (305 aa)
	ENSUAMP00000002886	Uncharacterized protein. (479 aa)
	ENSUAMP00000002924	Uncharacterized protein. (335 aa)
	PGP	Phosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (321 aa)
	TRIB3	Tribbles pseudokinase 3. (363 aa)
	GCK	Phosphotransferase. (466 aa)
	ETFBKMT	Electron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
	ENSUAMP00000006463	Uncharacterized protein. (89 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
	ENSUAMP00000006566	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (269 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1260 aa)
	DKK3	Dickkopf WNT signaling pathway inhibitor 3. (361 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	DKKL1	Dickkopf like acrosomal protein 1. (233 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (197 aa)
	TSPO	Translocator protein. (169 aa)
	DDIT4	DNA damage inducible transcript 4. (231 aa)
	ENSUAMP00000011272	FBPase domain-containing protein; Belongs to the FBPase class 1 family. (293 aa)
	ENSUAMP00000011275	FBPase domain-containing protein. (57 aa)
	SLC4A1	Anion exchange protein. (853 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
	ENSUAMP00000012044	TGF_BETA_2 domain-containing protein. (154 aa)
	NUPR1	Nuclear protein 1, transcriptional regulator. (82 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (815 aa)
	FAM3A	Family with sequence similarity 3 member A. (280 aa)
	ENSUAMP00000016504	BRCT domain-containing protein. (101 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (975 aa)
	PDZD3	PDZ domain containing 3. (508 aa)
	ACADVL	Acyl-CoA dehydrogenase very long chain. (655 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (942 aa)
	SNAI2	Snail family transcriptional repressor 2. (230 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (411 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	FIS1	Fission, mitochondrial 1. (166 aa)
	SIRT1	Sirtuin 1. (618 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	ENSUAMP00000021972	Uncharacterized protein. (778 aa)
	FAM3C	Family with sequence similarity 3 member C. (214 aa)
	PRMT3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (516 aa)
	ENSUAMP00000023021	Flavin-containing monooxygenase. (254 aa)
	ENSUAMP00000023027	Flavin-containing monooxygenase. (185 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (457 aa)
	SIRT6	Sirtuin 6. (338 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (312 aa)
	NCOR1	Nuclear receptor corepressor 1. (2267 aa)
	ENSUAMP00000025261	GPS2_interact domain-containing protein. (204 aa)
	SOX9	SRY-box transcription factor 9. (484 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	GFI1	Growth factor independent 1 transcriptional repressor. (448 aa)
	LEPR	Leptin receptor. (1166 aa)
	GIT1	GIT ArfGAP 1. (708 aa)
	FMO2	Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
	FMO1	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	FMO4	Dimethylaniline monooxygenase [N-oxide-forming]. (556 aa)
	ENSUAMP00000030569	Uncharacterized protein. (137 aa)
	APOE	Apolipoprotein E. (323 aa)
	ERLIN2	ER lipid raft associated 2. (337 aa)
	ATCAY	ATCAY kinesin light chain interacting caytaxin. (355 aa)
	EP300	E1A binding protein p300. (2399 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (203 aa)
	CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3. (748 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (652 aa)
	CRY1	Cryptochrome circadian regulator 1. (587 aa)
	ENSUAMP00000034736	HDAC4_Gln domain-containing protein. (230 aa)
	SNAI1	Snail family transcriptional repressor 1. (259 aa)
	ENSUAMP00000036868	Uncharacterized protein. (379 aa)
	ERLIN1	ER lipid raft associated 1. (348 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APOE	ENSUAMP00000020191	ENSUAMP00000030573	Adiponectin, C1Q and collagen domain containing.	Apolipoprotein E.	0.459
ADIPOQ	APPL2	ENSUAMP00000020191	ENSUAMP00000034646	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.512
ADIPOQ	INS	ENSUAMP00000020191	ENSUAMP00000026996	Adiponectin, C1Q and collagen domain containing.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.750
ADIPOQ	LEPR	ENSUAMP00000020191	ENSUAMP00000027698	Adiponectin, C1Q and collagen domain containing.	Leptin receptor.	0.542
ADIPOQ	PGP	ENSUAMP00000020191	ENSUAMP00000004911	Adiponectin, C1Q and collagen domain containing.	Phosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily.	0.402
ADIPOQ	PLIN5	ENSUAMP00000020191	ENSUAMP00000024565	Adiponectin, C1Q and collagen domain containing.	Perilipin; Belongs to the perilipin family.	0.634
ADIPOQ	SIRT1	ENSUAMP00000020191	ENSUAMP00000021491	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.521
ADIPOQ	STAT3	ENSUAMP00000020191	ENSUAMP00000008772	Adiponectin, C1Q and collagen domain containing.	Signal transducer and activator of transcription.	0.406
APOE	ADIPOQ	ENSUAMP00000030573	ENSUAMP00000020191	Apolipoprotein E.	Adiponectin, C1Q and collagen domain containing.	0.459
APOE	ENSUAMP00000006463	ENSUAMP00000030573	ENSUAMP00000006463	Apolipoprotein E.	Uncharacterized protein.	0.891
APOE	ENSUAMP00000030569	ENSUAMP00000030573	ENSUAMP00000030569	Apolipoprotein E.	Uncharacterized protein.	0.891
APOE	INS	ENSUAMP00000030573	ENSUAMP00000026996	Apolipoprotein E.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.641
APOE	SIRT1	ENSUAMP00000030573	ENSUAMP00000021491	Apolipoprotein E.	Sirtuin 1.	0.439
APOE	TP53	ENSUAMP00000030573	ENSUAMP00000000913	Apolipoprotein E.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.457
APPL2	ADIPOQ	ENSUAMP00000034646	ENSUAMP00000020191	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adiponectin, C1Q and collagen domain containing.	0.512
APPL2	ATCAY	ENSUAMP00000034646	ENSUAMP00000031184	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	ATCAY kinesin light chain interacting caytaxin.	0.490
ATCAY	APPL2	ENSUAMP00000031184	ENSUAMP00000034646	ATCAY kinesin light chain interacting caytaxin.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.490
ATCAY	EP300	ENSUAMP00000031184	ENSUAMP00000031856	ATCAY kinesin light chain interacting caytaxin.	E1A binding protein p300.	0.466
BMP2	ENSUAMP00000012044	ENSUAMP00000021596	ENSUAMP00000012044	Bone morphogenetic protein 2.	TGF_BETA_2 domain-containing protein.	0.730
BMP2	FGF19	ENSUAMP00000021596	ENSUAMP00000032520	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534