(94 nodes) Extracellular exosome network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCDC180	Coiled-coil domain containing 180. (1584 aa)
	PLAA	Phospholipase A2 activating protein. (691 aa)
	ENSUAMP00000006080	Uncharacterized protein. (227 aa)
	HGD	Homogentisate 1,2-dioxygenase. (445 aa)
	ANXA1	Annexin. (345 aa)
	ENSUAMP00000005459	Uncharacterized protein. (783 aa)
	BPGM	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (260 aa)
	PTER	Phosphotriesterase related. (349 aa)
	XPNPEP2	X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family. (614 aa)
	ENSUAMP00000002331	RRM domain-containing protein. (80 aa)
	LAMP2	Lysosomal associated membrane protein 2. (411 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (696 aa)
	ABCB6	ATP binding cassette subfamily B member 6 (Langereis blood group). (842 aa)
	PEPD	Peptidase D. (509 aa)
	GPRC5B	G protein-coupled receptor class C group 5 member B. (387 aa)
	CA4	Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (313 aa)
	ENSUAMP00000030909	SKICH domain-containing protein. (97 aa)
	CD81	Tetraspanin. (392 aa)
	ENSUAMP00000031501	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	BHMT2	Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (363 aa)
	BHMT	Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (407 aa)
	SORD	Sorbitol dehydrogenase. (319 aa)
	FN1	Fibronectin 1. (2385 aa)
	FAH	Fumarylacetoacetase. (419 aa)
	TTC38	Tetratricopeptide repeat domain 38. (469 aa)
	NSUN2	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (799 aa)
	AOC1	Amine oxidase. (757 aa)
	ARMC3	Armadillo repeat containing 3. (875 aa)
	ENSUAMP00000033373	STAS domain-containing protein. (230 aa)
	ENSUAMP00000033467	annotation not available (164 aa)
	SMS	Spermine synthase. (383 aa)
	RAB11A	RAB11A, member RAS oncogene family. (210 aa)
	SRI	Sorcin. (198 aa)
	CCDC105	Coiled-coil domain containing 105. (499 aa)
	ALB	Albumin. (609 aa)
	ENSUAMP00000007730	Uncharacterized protein. (206 aa)
	ENSUAMP00000007637	Uncharacterized protein. (172 aa)
	ITGA2B	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1032 aa)
	ENSUAMP00000006845	Sulfate_transp domain-containing protein. (515 aa)
	KCNMA1	Potassium calcium-activated channel subfamily M alpha 1. (1143 aa)
	VASN	Vasorin. (676 aa)
	ENSUAMP00000009568	Uncharacterized protein. (342 aa)
	ENSUAMP00000009761	Uncharacterized protein. (200 aa)
	ENSUAMP00000011462	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	BEND7	BEN domain containing 7. (428 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (911 aa)
	ENSUAMP00000013917	Uncharacterized protein. (389 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1870 aa)
	ARHGAP23	Rho GTPase activating protein 23. (1301 aa)
	BAG6	BCL2 associated athanogene 6. (1164 aa)
	ENSUAMP00000016165	Uncharacterized protein. (565 aa)
	PLEKHA7	Pleckstrin homology domain containing A7. (1165 aa)
	HBS1L	HBS1 like translational GTPase. (685 aa)
	SNX18	Sorting nexin. (624 aa)
	RBMX	RRM domain-containing protein. (391 aa)
	ENSUAMP00000018027	IF rod domain-containing protein; Belongs to the intermediate filament family. (463 aa)
	ENSUAMP00000018029	IF rod domain-containing protein; Belongs to the intermediate filament family. (440 aa)
	ADAM15	ADAM metallopeptidase domain 15. (832 aa)
	RAB5B	RAB5B, member RAS oncogene family. (215 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	ENSUAMP00000019533	CSD domain-containing protein. (311 aa)
	SH3BGRL	SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (108 aa)
	GPRC5D	G protein-coupled receptor class C group 5 member D. (344 aa)
	GPRC5A	G protein-coupled receptor class C group 5 member A. (352 aa)
	QSOX1	Sulfhydryl oxidase. (740 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa)
	GARS1	Glycyl-tRNA synthetase. (739 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (148 aa)
	SCRN2	Secernin 2. (425 aa)
	C16orf89	Chromosome 16 open reading frame 89. (373 aa)
	COBLL1	Cordon-bleu WH2 repeat protein like 1. (1212 aa)
	FAM3C	Family with sequence similarity 3 member C. (214 aa)
	SLC12A3	Solute carrier family 12 member 3. (1105 aa)
	ENSUAMP00000022738	Uncharacterized protein. (126 aa)
	PROM1	Prominin 1. (812 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	C11orf52	Chromosome 11 open reading frame 52. (131 aa)
	ENSUAMP00000023803	CSP domain-containing protein. (311 aa)
	ENSUAMP00000024186	Uncharacterized protein. (196 aa)
	RAB4A	RAB4A, member RAS oncogene family. (215 aa)
	TSG101	Tumor susceptibility 101. (353 aa)
	ENSUAMP00000025327	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa)
	ENSUAMP00000025480	Uncharacterized protein. (157 aa)
	SLC12A1	Solute carrier family 12 member 1. (973 aa)
	ENSUAMP00000001281	RRM domain-containing protein. (72 aa)
	CPVL	Carboxypeptidase vitellogenic like; Belongs to the peptidase S10 family. (387 aa)
	ENSUAMP00000026965	M20_dimer domain-containing protein. (408 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
	CD47	CD47 molecule. (320 aa)
	CYSRT1	Cysteine rich tail 1. (141 aa)
	SLC9A3	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (908 aa)
	ENSUAMP00000029257	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (231 aa)
	ENSUAMP00000029258	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (369 aa)
	CD9	Tetraspanin. (226 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	ALB	ENSUAMP00000013187	ENSUAMP00000008269	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Albumin.	0.443
AGO2	CD81	ENSUAMP00000013187	ENSUAMP00000031375	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Tetraspanin.	0.429
AGO2	CD9	ENSUAMP00000013187	ENSUAMP00000029266	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Tetraspanin.	0.426
AGO2	DICER1	ENSUAMP00000013187	ENSUAMP00000014842	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.996
AGO2	ENSUAMP00000019533	ENSUAMP00000013187	ENSUAMP00000019533	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CSD domain-containing protein.	0.585
AGO2	ENSUAMP00000023803	ENSUAMP00000013187	ENSUAMP00000023803	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CSP domain-containing protein.	0.585
AGO2	ENSUAMP00000025480	ENSUAMP00000013187	ENSUAMP00000025480	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.585
AGO2	TSG101	ENSUAMP00000013187	ENSUAMP00000024471	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Tumor susceptibility 101.	0.486
ALB	AGO2	ENSUAMP00000008269	ENSUAMP00000013187	Albumin.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.443
ALB	ANXA1	ENSUAMP00000008269	ENSUAMP00000005904	Albumin.	Annexin.	0.623
ALB	CA4	ENSUAMP00000008269	ENSUAMP00000030208	Albumin.	Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family.	0.469
ALB	CD47	ENSUAMP00000008269	ENSUAMP00000027480	Albumin.	CD47 molecule.	0.583
ALB	CD81	ENSUAMP00000008269	ENSUAMP00000031375	Albumin.	Tetraspanin.	0.559
ALB	CD9	ENSUAMP00000008269	ENSUAMP00000029266	Albumin.	Tetraspanin.	0.609
ALB	DICER1	ENSUAMP00000008269	ENSUAMP00000014842	Albumin.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.459
ALB	ENSUAMP00000011462	ENSUAMP00000008269	ENSUAMP00000011462	Albumin.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.453
ALB	ENSUAMP00000022738	ENSUAMP00000008269	ENSUAMP00000022738	Albumin.	Uncharacterized protein.	0.459
ALB	FAH	ENSUAMP00000008269	ENSUAMP00000032444	Albumin.	Fumarylacetoacetase.	0.466
ALB	FN1	ENSUAMP00000008269	ENSUAMP00000032386	Albumin.	Fibronectin 1.	0.630
ALB	LAMP2	ENSUAMP00000008269	ENSUAMP00000008665	Albumin.	Lysosomal associated membrane protein 2.	0.525