(21 nodes) T cell apoptotic process network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GLI3	GLI family zinc finger 3. (1413 aa)
	BCL2L11	BCL2 like 11. (140 aa)
	ENSUAMP00000022738	Uncharacterized protein. (126 aa)
	ADA	Adenosine deaminase. (385 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (550 aa)
	ENSUAMP00000018082	Uncharacterized protein. (249 aa)
	ENSUAMP00000027842	Uncharacterized protein. (99 aa)
	CHEK2	Checkpoint kinase 2. (530 aa)
	ENSUAMP00000009098	C2H2-type domain-containing protein. (235 aa)
	BCL10	BCL10 immune signaling adaptor. (234 aa)
	ENSUAMP00000008680	Uncharacterized protein. (251 aa)
	ENSUAMP00000005615	Uncharacterized protein. (177 aa)
	ENSUAMP00000001571	Uncharacterized protein. (289 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	ENSUAMP00000027843	Uncharacterized protein. (119 aa)
	ENSUAMP00000024489	Uncharacterized protein. (451 aa)
	BCL3	BCL3 transcription coactivator. (424 aa)
	LMBR1L	Limb development membrane protein 1 like. (317 aa)
	ENSUAMP00000035027	Uncharacterized protein. (146 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BCL2L11	ENSUAMP00000000602	ENSUAMP00000029698	BCL2 antagonist/killer 1.	BCL2 like 11.	0.972
BAK1	ENSUAMP00000035027	ENSUAMP00000000602	ENSUAMP00000035027	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.802
BAK1	TP53	ENSUAMP00000000602	ENSUAMP00000000913	BCL2 antagonist/killer 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.984
BCL10	RIPK1	ENSUAMP00000024740	ENSUAMP00000019468	BCL10 immune signaling adaptor.	Receptor interacting serine/threonine kinase 1.	0.417
BCL2L11	BAK1	ENSUAMP00000029698	ENSUAMP00000000602	BCL2 like 11.	BCL2 antagonist/killer 1.	0.972
BCL2L11	ENSUAMP00000022738	ENSUAMP00000029698	ENSUAMP00000022738	BCL2 like 11.	Uncharacterized protein.	0.459
BCL2L11	ENSUAMP00000035027	ENSUAMP00000029698	ENSUAMP00000035027	BCL2 like 11.	Uncharacterized protein.	0.953
BCL2L11	TP53	ENSUAMP00000029698	ENSUAMP00000000913	BCL2 like 11.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.414
CHEK2	TP53	ENSUAMP00000014002	ENSUAMP00000000913	Checkpoint kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.990
ENSUAMP00000001571	ENSUAMP00000024489	ENSUAMP00000001571	ENSUAMP00000024489	Uncharacterized protein.	Uncharacterized protein.	0.872
ENSUAMP00000018082	ENSUAMP00000022738	ENSUAMP00000018082	ENSUAMP00000022738	Uncharacterized protein.	Uncharacterized protein.	0.994
ENSUAMP00000018082	RIPK1	ENSUAMP00000018082	ENSUAMP00000019468	Uncharacterized protein.	Receptor interacting serine/threonine kinase 1.	0.775
ENSUAMP00000022738	BCL2L11	ENSUAMP00000022738	ENSUAMP00000029698	Uncharacterized protein.	BCL2 like 11.	0.459
ENSUAMP00000022738	ENSUAMP00000018082	ENSUAMP00000022738	ENSUAMP00000018082	Uncharacterized protein.	Uncharacterized protein.	0.994
ENSUAMP00000022738	RIPK1	ENSUAMP00000022738	ENSUAMP00000019468	Uncharacterized protein.	Receptor interacting serine/threonine kinase 1.	0.730
ENSUAMP00000022738	TP53	ENSUAMP00000022738	ENSUAMP00000000913	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.574
ENSUAMP00000024489	ENSUAMP00000001571	ENSUAMP00000024489	ENSUAMP00000001571	Uncharacterized protein.	Uncharacterized protein.	0.872
ENSUAMP00000035027	BAK1	ENSUAMP00000035027	ENSUAMP00000000602	Uncharacterized protein.	BCL2 antagonist/killer 1.	0.802
ENSUAMP00000035027	BCL2L11	ENSUAMP00000035027	ENSUAMP00000029698	Uncharacterized protein.	BCL2 like 11.	0.953
ENSUAMP00000035027	TP53	ENSUAMP00000035027	ENSUAMP00000000913	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.693