(45 nodes) U2-type precatalytic spliceosome network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRPF38A	Pre-mRNA processing factor 38A. (312 aa)
	ENSUAMP00000037248	MPN domain-containing protein. (979 aa)
	SF3B5	Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
	DHX16	DEAH-box helicase 16. (1041 aa)
	SMU1	SMU1 DNA replication regulator and spliceosomal factor. (513 aa)
	MFAP1	Microfibril associated protein 1. (439 aa)
	SNRPD2-3	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
	PHF5A	PHD finger protein 5A. (85 aa)
	SNRPD2-2	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (123 aa)
	ENSUAMP00000026961	Uncharacterized protein. (113 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (765 aa)
	SF3B2	Splicing factor 3b subunit 2. (910 aa)
	BUD13	BUD13 homolog. (657 aa)
	SF3B1	Splicing factor 3b subunit 1. (1122 aa)
	PRPF4	Pre-mRNA processing factor 4. (369 aa)
	SNRPB2	Small nuclear ribonucleoprotein polypeptide B2. (224 aa)
	SRRM2	Serine/arginine repetitive matrix 2. (2862 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (114 aa)
	ENSUAMP00000021056	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
	ENSUAMP00000019788	Uncharacterized protein. (1338 aa)
	SNIP1	Smad nuclear interacting protein 1. (392 aa)
	CWC27	CWC27 spliceosome associated cyclophilin. (340 aa)
	CWC22	CWC22 spliceosome associated protein homolog. (910 aa)
	WBP4	WW domain binding protein 4. (373 aa)
	SNRPA1	Small nuclear ribonucleoprotein polypeptide A. (257 aa)
	PRPF3	Pre-mRNA processing factor 3. (548 aa)
	ENSUAMP00000011444	PWI domain-containing protein. (112 aa)
	ENSUAMP00000010169	Uncharacterized protein. (1045 aa)
	ENSUAMP00000010166	SEC63 domain-containing protein. (329 aa)
	SNRPD2	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (53 aa)
	LSM8-2	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (92 aa)
	SF3B3	Splicing factor 3b subunit 3. (1217 aa)
	SF3A1	Splicing factor 3a subunit 1. (795 aa)
	SF3A3	Splicing factor 3a subunit 3. (501 aa)
	PRPF31	Pre-mRNA processing factor 31. (499 aa)
	ENSUAMP00000005212	RED_C domain-containing protein. (188 aa)
	ZMAT2	Zinc finger matrin-type 2. (192 aa)
	TXNL4A	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (188 aa)
	SNU13	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
	PRPF6	Pre-mRNA processing factor 6. (758 aa)
	EFTUD2	Elongation factor Tu GTP binding domain containing 2. (970 aa)
	ENSUAMP00000001028	SF3A2 domain-containing protein. (192 aa)
	LSM7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (120 aa)
	LSM4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BUD13	CWC22	ENSUAMP00000025582	ENSUAMP00000013498	BUD13 homolog.	CWC22 spliceosome associated protein homolog.	0.966
BUD13	CWC27	ENSUAMP00000025582	ENSUAMP00000017565	BUD13 homolog.	CWC27 spliceosome associated cyclophilin.	0.954
BUD13	DHX16	ENSUAMP00000025582	ENSUAMP00000034929	BUD13 homolog.	DEAH-box helicase 16.	0.964
BUD13	EFTUD2	ENSUAMP00000025582	ENSUAMP00000001067	BUD13 homolog.	Elongation factor Tu GTP binding domain containing 2.	0.951
BUD13	ENSUAMP00000001028	ENSUAMP00000025582	ENSUAMP00000001028	BUD13 homolog.	SF3A2 domain-containing protein.	0.943
BUD13	ENSUAMP00000010166	ENSUAMP00000025582	ENSUAMP00000010166	BUD13 homolog.	SEC63 domain-containing protein.	0.886
BUD13	ENSUAMP00000010169	ENSUAMP00000025582	ENSUAMP00000010169	BUD13 homolog.	Uncharacterized protein.	0.886
BUD13	ENSUAMP00000011444	ENSUAMP00000025582	ENSUAMP00000011444	BUD13 homolog.	PWI domain-containing protein.	0.675
BUD13	ENSUAMP00000019788	ENSUAMP00000025582	ENSUAMP00000019788	BUD13 homolog.	Uncharacterized protein.	0.880
BUD13	ENSUAMP00000021056	ENSUAMP00000025582	ENSUAMP00000021056	BUD13 homolog.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.557
BUD13	ENSUAMP00000037248	ENSUAMP00000025582	ENSUAMP00000037248	BUD13 homolog.	MPN domain-containing protein.	0.880
BUD13	LSM3	ENSUAMP00000025582	ENSUAMP00000021919	BUD13 homolog.	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.759
BUD13	LSM4	ENSUAMP00000025582	ENSUAMP00000000719	BUD13 homolog.	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.765
BUD13	LSM7	ENSUAMP00000025582	ENSUAMP00000000925	BUD13 homolog.	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated.	0.843
BUD13	LSM8	ENSUAMP00000025582	ENSUAMP00000008123	BUD13 homolog.	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.570
BUD13	LSM8-2	ENSUAMP00000025582	ENSUAMP00000008124	BUD13 homolog.	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.570
BUD13	MFAP1	ENSUAMP00000025582	ENSUAMP00000033124	BUD13 homolog.	Microfibril associated protein 1.	0.963
BUD13	PHF5A	ENSUAMP00000025582	ENSUAMP00000029305	BUD13 homolog.	PHD finger protein 5A.	0.979
BUD13	PRPF3	ENSUAMP00000025582	ENSUAMP00000011449	BUD13 homolog.	Pre-mRNA processing factor 3.	0.783
BUD13	PRPF31	ENSUAMP00000025582	ENSUAMP00000005928	BUD13 homolog.	Pre-mRNA processing factor 31.	0.816