STRINGSTRING
ENSUAMP00000010072 ENSUAMP00000010072 SNRPD2 SNRPD2 SNRPF SNRPF BUD31 BUD31 ENSUAMP00000009322 ENSUAMP00000009322 SF3B3 SF3B3 SF3A1 SF3A1 SF3A3 SF3A3 ENSUAMP00000004053 ENSUAMP00000004053 SF3B2 SF3B2 SART1 SART1 ENSUAMP00000026961 ENSUAMP00000026961 BCAS2 BCAS2 CDC40 CDC40 ESS2 ESS2 ENSUAMP00000026187 ENSUAMP00000026187 DHX38 DHX38 ENSUAMP00000020844 ENSUAMP00000020844 WDR25 WDR25 ENSUAMP00000020708 ENSUAMP00000020708 SNRPN SNRPN TFIP11 TFIP11 ENSUAMP00000020605 ENSUAMP00000020605 ENSUAMP00000020587 ENSUAMP00000020587 EIF4A2 EIF4A2 ENSUAMP00000019788 ENSUAMP00000019788 ENSUAMP00000019764 ENSUAMP00000019764 AQR AQR ENSUAMP00000021295 ENSUAMP00000021295 CACTIN CACTIN LSM3 LSM3 SRRM2 SRRM2 SNRNP40 SNRNP40 CDC5L CDC5L ENSUAMP00000037248 ENSUAMP00000037248 EIF4A3 EIF4A3 SNRPB2 SNRPB2 DHX8 DHX8 PLRG1 PLRG1 CRNKL1 CRNKL1 ENSUAMP00000024269 ENSUAMP00000024269 SF3B1 SF3B1 XAB2 XAB2 WDR83 WDR83 CWC27 CWC27 ZCCHC8 ZCCHC8 SNRPD1 SNRPD1 RBMX RBMX ENSUAMP00000015105 ENSUAMP00000015105 ENSUAMP00000014628 ENSUAMP00000014628 PRPF19 PRPF19 ENSUAMP00000013972 ENSUAMP00000013972 DDX23 DDX23 HNRNPR HNRNPR PRPF4B PRPF4B CWC15 CWC15 ENSUAMP00000033911 ENSUAMP00000033911 ENSUAMP00000033230 ENSUAMP00000033230 RBM22 RBM22 PABPC1 PABPC1 DDX5 DDX5 DDX41 DDX41 SNRPD2-3 SNRPD2-3 MTREX MTREX SNRPD2-2 SNRPD2-2 SNW1 SNW1 HNRNPU HNRNPU RBM8A RBM8A PNN PNN C19orf54 C19orf54 SYF2 SYF2 PRPF6 PRPF6 ENSUAMP00000002331 ENSUAMP00000002331 ENSUAMP00000001657 ENSUAMP00000001657 ENSUAMP00000001281 ENSUAMP00000001281 ENSUAMP00000001138 ENSUAMP00000001138 EFTUD2 EFTUD2 PPIL2 PPIL2 ENSUAMP00000028083 ENSUAMP00000028083 ENSUAMP00000001028 ENSUAMP00000001028 ENSUAMP00000000999 ENSUAMP00000000999 LSM7 LSM7 ENSUAMP00000000623 ENSUAMP00000000623 PPIL1 PPIL1 CWC22 CWC22 SNRPD3 SNRPD3 ENSUAMP00000012147 ENSUAMP00000012147 MAGOH MAGOH DHX35 DHX35 SNRPA1 SNRPA1 SYNCRIP SYNCRIP ENSUAMP00000010169 ENSUAMP00000010169 ENSUAMP00000010166 ENSUAMP00000010166
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000010072Sm domain-containing protein. (105 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (53 aa)
SNRPFSm domain-containing protein. (86 aa)
BUD31BUD31 homolog. (144 aa)
ENSUAMP00000009322RRM domain-containing protein. (325 aa)
SF3B3Splicing factor 3b subunit 3. (1217 aa)
SF3A1Splicing factor 3a subunit 1. (795 aa)
SF3A3Splicing factor 3a subunit 3. (501 aa)
ENSUAMP00000004053Uncharacterized protein. (104 aa)
SF3B2Splicing factor 3b subunit 2. (910 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (765 aa)
ENSUAMP00000026961Uncharacterized protein. (113 aa)
BCAS2BCAS2 pre-mRNA processing factor. (203 aa)
CDC40Cell division cycle 40. (318 aa)
ESS2Ess-2 splicing factor homolog. (478 aa)
ENSUAMP00000026187Sm domain-containing protein. (72 aa)
DHX38DEAH-box helicase 38. (1228 aa)
ENSUAMP00000020844Uncharacterized protein. (68 aa)
WDR25WD repeat domain 25. (477 aa)
ENSUAMP00000020708Sm domain-containing protein. (74 aa)
SNRPNSmall nuclear ribonucleoprotein polypeptide N. (287 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (777 aa)
ENSUAMP00000020605Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (159 aa)
ENSUAMP00000020587Uncharacterized protein. (100 aa)
EIF4A2Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family. (408 aa)
ENSUAMP00000019788Uncharacterized protein. (1338 aa)
ENSUAMP00000019764DUF1604 domain-containing protein. (140 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1479 aa)
ENSUAMP00000021295Uncharacterized protein. (103 aa)
CACTINCactin, spliceosome C complex subunit. (752 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (114 aa)
SRRM2Serine/arginine repetitive matrix 2. (2862 aa)
SNRNP40Small nuclear ribonucleoprotein U5 subunit 40. (358 aa)
CDC5LCell division cycle 5 like. (544 aa)
ENSUAMP00000037248MPN domain-containing protein. (979 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
SNRPB2Small nuclear ribonucleoprotein polypeptide B2. (224 aa)
DHX8DEAH-box helicase 8. (1218 aa)
PLRG1Pleiotropic regulator 1. (503 aa)
CRNKL1Crooked neck pre-mRNA splicing factor 1. (687 aa)
ENSUAMP00000024269Uncharacterized protein. (113 aa)
SF3B1Splicing factor 3b subunit 1. (1122 aa)
XAB2XPA binding protein 2. (855 aa)
WDR83WD repeat domain 83. (315 aa)
CWC27CWC27 spliceosome associated cyclophilin. (340 aa)
ZCCHC8Zinc finger CCHC-type containing 8. (646 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (117 aa)
RBMXRRM domain-containing protein. (391 aa)
ENSUAMP00000015105Uncharacterized protein. (238 aa)
ENSUAMP00000014628PWI domain-containing protein. (90 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
ENSUAMP00000013972Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (163 aa)
DDX23DEAD-box helicase 23. (820 aa)
HNRNPRHeterogeneous nuclear ribonucleoprotein R. (633 aa)
PRPF4BPre-mRNA processing factor 4B. (1041 aa)
CWC15CWC15 spliceosome associated protein homolog. (230 aa)
ENSUAMP00000033911Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
ENSUAMP00000033230RRM domain-containing protein. (125 aa)
RBM22RNA binding motif protein 22. (420 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
DDX41DEAD-box helicase 41. (649 aa)
SNRPD2-3Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
MTREXMtr4 exosome RNA helicase. (1042 aa)
SNRPD2-2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (123 aa)
SNW1SNW domain containing 1. (511 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
PNNPinin, desmosome associated protein. (701 aa)
C19orf54Chromosome 19 open reading frame 54. (346 aa)
SYF2SYF2 pre-mRNA splicing factor. (246 aa)
PRPF6Pre-mRNA processing factor 6. (758 aa)
ENSUAMP00000002331RRM domain-containing protein. (80 aa)
ENSUAMP00000001657Uncharacterized protein. (70 aa)
ENSUAMP00000001281RRM domain-containing protein. (72 aa)
ENSUAMP00000001138Sm domain-containing protein. (85 aa)
EFTUD2Elongation factor Tu GTP binding domain containing 2. (970 aa)
PPIL2Peptidylprolyl isomerase like 2. (521 aa)
ENSUAMP00000028083Uncharacterized protein. (88 aa)
ENSUAMP00000001028SF3A2 domain-containing protein. (192 aa)
ENSUAMP00000000999RRM domain-containing protein. (126 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (120 aa)
ENSUAMP00000000623Uncharacterized protein. (86 aa)
PPIL1Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
CWC22CWC22 spliceosome associated protein homolog. (910 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
ENSUAMP00000012147Uncharacterized protein. (248 aa)
MAGOHMago homolog, exon junction complex subunit. (146 aa)
DHX35DEAH-box helicase 35. (708 aa)
SNRPA1Small nuclear ribonucleoprotein polypeptide A. (257 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (562 aa)
ENSUAMP00000010169Uncharacterized protein. (1045 aa)
ENSUAMP00000010166SEC63 domain-containing protein. (329 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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