(64 nodes) Nephron tubule development network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (272 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	LHX1	LIM homeobox 1. (406 aa)
	TMEM59L	Transmembrane protein 59 like. (350 aa)
	ENSUAMP00000037194	BTB domain-containing protein. (195 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	NOTCH2	Notch receptor 2. (2374 aa)
	ILK	Integrin linked kinase. (503 aa)
	IRX2	Iroquois homeobox 2. (330 aa)
	AHI1	Abelson helper integration site 1. (1054 aa)
	GLI3	GLI family zinc finger 3. (1413 aa)
	NPNT	Nephronectin. (462 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (806 aa)
	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif 16. (1250 aa)
	TFAP2B	Transcription factor AP-2 beta. (460 aa)
	ENSUAMP00000030255	Uncharacterized protein. (92 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1923 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (897 aa)
	ENSUAMP00000029322	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (757 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	GATA3	GATA binding protein 3. (444 aa)
	ENSUAMP00000028271	Uncharacterized protein. (459 aa)
	ENSUAMP00000028270	Uncharacterized protein. (220 aa)
	ENSUAMP00000027843	Uncharacterized protein. (119 aa)
	ENSUAMP00000027842	Uncharacterized protein. (99 aa)
	SOX9	SRY-box transcription factor 9. (484 aa)
	PAX8	Paired box 8. (458 aa)
	TCF21	Transcription factor 21. (179 aa)
	ENSUAMP00000023713	Uncharacterized protein. (348 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
	CALB1	Calbindin 1. (248 aa)
	WT1	WT1 transcription factor. (522 aa)
	GDNF	Glial cell derived neurotrophic factor. (211 aa)
	IRX1	Iroquois homeobox 1. (447 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	ENSUAMP00000020431	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (70 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	HOXA11	Homeobox A11. (313 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1926 aa)
	ENSUAMP00000017478	Guanylate kinase-like domain-containing protein. (307 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1234 aa)
	SOX8	SRY-box transcription factor 8. (449 aa)
	IRX3	Iroquois homeobox 3. (502 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (971 aa)
	GREB1	Uncharacterized protein. (1953 aa)
	ENSUAMP00000011462	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	HES1	Hes family bHLH transcription factor 1. (259 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (323 aa)
	PTCH1	Patched 1. (1453 aa)
	ENSUAMP00000003258	Uncharacterized protein. (246 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (240 aa)
	MTSS1	MTSS I-BAR domain containing 1. (686 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS16	IRX1	ENSUAMP00000030667	ENSUAMP00000021750	ADAM metallopeptidase with thrombospondin type 1 motif 16.	Iroquois homeobox 1.	0.636
AQP11	ENSUAMP00000011462	ENSUAMP00000002079	ENSUAMP00000011462	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.732
BMP2	BMP4	ENSUAMP00000021596	ENSUAMP00000028868	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.943
BMP2	ENSUAMP00000029322	ENSUAMP00000021596	ENSUAMP00000029322	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.721
BMP2	FGF1	ENSUAMP00000021596	ENSUAMP00000029895	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.461
BMP2	GPC3	ENSUAMP00000021596	ENSUAMP00000021714	Bone morphogenetic protein 2.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.429
BMP2	GREM1	ENSUAMP00000021596	ENSUAMP00000002257	Bone morphogenetic protein 2.	Gremlin 1, DAN family BMP antagonist.	0.948
BMP2	NOG	ENSUAMP00000021596	ENSUAMP00000001684	Bone morphogenetic protein 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.990
BMP2	SMAD4	ENSUAMP00000021596	ENSUAMP00000018392	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.854
BMP2	SOX9	ENSUAMP00000021596	ENSUAMP00000026554	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.578
BMP4	BMP2	ENSUAMP00000028868	ENSUAMP00000021596	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.943
BMP4	ENSUAMP00000029322	ENSUAMP00000028868	ENSUAMP00000029322	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.753
BMP4	FGF1	ENSUAMP00000028868	ENSUAMP00000029895	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.442
BMP4	GATA3	ENSUAMP00000028868	ENSUAMP00000028860	Bone morphogenetic protein 4.	GATA binding protein 3.	0.417
BMP4	GDNF	ENSUAMP00000028868	ENSUAMP00000021859	Bone morphogenetic protein 4.	Glial cell derived neurotrophic factor.	0.453
BMP4	GPC3	ENSUAMP00000028868	ENSUAMP00000021714	Bone morphogenetic protein 4.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.429
BMP4	GREM1	ENSUAMP00000028868	ENSUAMP00000002257	Bone morphogenetic protein 4.	Gremlin 1, DAN family BMP antagonist.	0.937
BMP4	JAG1	ENSUAMP00000028868	ENSUAMP00000034607	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.656
BMP4	MEF2C	ENSUAMP00000028868	ENSUAMP00000029640	Bone morphogenetic protein 4.	Myocyte enhancer factor 2C.	0.418
BMP4	NOG	ENSUAMP00000028868	ENSUAMP00000001684	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.996