STRINGSTRING
XRCC5 XRCC5 FGF9 FGF9 ENSUAMP00000005628 ENSUAMP00000005628 ENSUAMP00000005842 ENSUAMP00000005842 CTC1 CTC1 ENSUAMP00000006989 ENSUAMP00000006989 ETV6 ETV6 TP63 TP63 PTCH1 PTCH1 WNT2B WNT2B FGF10 FGF10 HMX2 HMX2 ENSUAMP00000009377 ENSUAMP00000009377 YTHDF2 YTHDF2 RARB RARB BABAM1 BABAM1 NES NES ENSUAMP00000017830 ENSUAMP00000017830 BRCA2 BRCA2 HOXA3 HOXA3 ENSUAMP00000018165 ENSUAMP00000018165 IRF6 IRF6 KDR KDR ENSUAMP00000023559 ENSUAMP00000023559 NF1 NF1 CDKN2C CDKN2C ENSUAMP00000025477 ENSUAMP00000025477 ERCC2 ERCC2 GBA GBA SOX9 SOX9 OVOL1 OVOL1 OSR2 OSR2 LIG4 LIG4 RARG RARG WNT11 WNT11 ENSUAMP00000001962 ENSUAMP00000001962 AXIN2 AXIN2 ENSUAMP00000001245 ENSUAMP00000001245 TP53 TP53 ENSUAMP00000000600 ENSUAMP00000000600 ENSUAMP00000027842 ENSUAMP00000027842 ENSUAMP00000027843 ENSUAMP00000027843 HOXB4 HOXB4 ENSUAMP00000029322 ENSUAMP00000029322 TRIM71 TRIM71 SART3 SART3 GLI3 GLI3 FGF4 FGF4 ELL3 ELL3 SFN SFN KDF1 KDF1 WNT1 WNT1 WNT10B WNT10B SCRG1 SCRG1 NR2E1 NR2E1 BYSL BYSL ENSUAMP00000036779 ENSUAMP00000036779
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XRCC5X-ray repair cross complementing 5. (501 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSUAMP00000005628SH2 domain-containing protein. (508 aa)
ENSUAMP00000005842RING-type domain-containing protein. (787 aa)
CTC1CST telomere replication complex component 1. (1227 aa)
ENSUAMP00000006989CTF/NF-I domain-containing protein. (213 aa)
ETV6ETS variant 6. (440 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PTCH1Patched 1. (1453 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
HMX2H6 family homeobox 2. (273 aa)
ENSUAMP00000009377Uncharacterized protein. (170 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (580 aa)
RARBRetinoic acid receptor beta. (336 aa)
BABAM1BRISC and BRCA1 A complex member 1. (336 aa)
NESNestin; Belongs to the intermediate filament family. (1793 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
BRCA2BRCA2 DNA repair associated. (3458 aa)
HOXA3Homeobox A3. (419 aa)
ENSUAMP00000018165Uncharacterized protein. (221 aa)
IRF6Interferon regulatory factor 6. (462 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
ENSUAMP00000023559Uncharacterized protein. (132 aa)
NF1Neurofibromin 1. (2845 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (759 aa)
GBAGlucosylceramidase. (540 aa)
SOX9SRY-box transcription factor 9. (484 aa)
OVOL1Ovo like transcriptional repressor 1. (247 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
LIG4DNA ligase. (911 aa)
RARGRetinoic acid receptor gamma. (458 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENSUAMP00000001962Uncharacterized protein. (141 aa)
AXIN2Axin 2. (843 aa)
ENSUAMP00000001245CTF/NF-I domain-containing protein. (195 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
HOXB4Homeobox B4. (240 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
TRIM71Tripartite motif containing 71. (858 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (964 aa)
GLI3GLI family zinc finger 3. (1413 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
ELL3Elongation factor for RNA polymerase II 3. (414 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SCRG1Stimulator of chondrogenesis 1. (98 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
BYSLBystin like. (437 aa)
ENSUAMP00000036779Uncharacterized protein. (167 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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