61 items (Ursus americanus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATXN1L	Ataxin 1 like. (688 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	ENSUAMP00000001245	CTF/NF-I domain-containing protein. (195 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	ENSUAMP00000003662	MYND-type domain-containing protein. (344 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ENSUAMP00000005136	Uncharacterized protein. (125 aa)
	PIM1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (392 aa)
	ENSUAMP00000006989	CTF/NF-I domain-containing protein. (213 aa)
	ENSUAMP00000007194	annotation not available (220 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	PTCH1	Patched 1. (1453 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (370 aa)
	HMX2	H6 family homeobox 2. (273 aa)
	ENSUAMP00000009377	Uncharacterized protein. (170 aa)
	ENSUAMP00000010127	Kindlin_2_N domain-containing protein. (70 aa)
	RARB	Retinoic acid receptor beta. (336 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	DGCR8	DGCR8 microprocessor complex subunit. (773 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
	FERMT1	Fermitin family member 1. (444 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	FERMT2	Fermitin family member 2. (567 aa)
	HOXA3	Homeobox A3. (419 aa)
	ENSUAMP00000019173	Uncharacterized protein; Belongs to the protein kinase superfamily. (417 aa)
	NF2	Neurofibromin 2. (596 aa)
	IRF6	Interferon regulatory factor 6. (462 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (195 aa)
	NF1	Neurofibromin 1. (2845 aa)
	KAT7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (592 aa)
	ENSUAMP00000025354	HMG box domain-containing protein. (302 aa)
	CDKN2C	Cyclin dependent kinase inhibitor 2C. (168 aa)
	ENSUAMP00000025477	Uncharacterized protein. (185 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (670 aa)
	ENSUAMP00000025721	Uncharacterized protein. (113 aa)
	SOX9	SRY-box transcription factor 9. (484 aa)
	OVOL1	Ovo like transcriptional repressor 1. (247 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1169 aa)
	OSR2	Odd-skipped related transciption factor 2. (312 aa)
	ENSUAMP00000027731	Kindlin_2_N domain-containing protein. (91 aa)
	ENSUAMP00000027842	Uncharacterized protein. (99 aa)
	ENSUAMP00000027843	Uncharacterized protein. (119 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	ENSUAMP00000029322	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
	GLI3	GLI family zinc finger 3. (1413 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
	ELL3	Elongation factor for RNA polymerase II 3. (414 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (248 aa)
	KDF1	Keratinocyte differentiation factor 1. (397 aa)
	GJA1	Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (382 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	HMGB2	High mobility group box 2. (210 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	SOX17	SRY-box transcription factor 17. (406 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNE1	TP53	ENSUAMP00000008795	ENSUAMP00000000913	Cyclin E1; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.581
CDKN2C	TP53	ENSUAMP00000025475	ENSUAMP00000000913	Cyclin dependent kinase inhibitor 2C.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.960
DGCR8	TP53	ENSUAMP00000013496	ENSUAMP00000000913	DGCR8 microprocessor complex subunit.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.435
DGCR8	VEGFC	ENSUAMP00000013496	ENSUAMP00000014341	DGCR8 microprocessor complex subunit.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.420
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000000600	SOX17	ENSUAMP00000000600	ENSUAMP00000036659	Uncharacterized protein.	SRY-box transcription factor 17.	0.433
ENSUAMP00000001245	ENSUAMP00000009377	ENSUAMP00000001245	ENSUAMP00000009377	CTF/NF-I domain-containing protein.	Uncharacterized protein.	0.666
ENSUAMP00000001245	NF1	ENSUAMP00000001245	ENSUAMP00000024136	CTF/NF-I domain-containing protein.	Neurofibromin 1.	0.442
ENSUAMP00000005136	ENSUAMP00000029322	ENSUAMP00000005136	ENSUAMP00000029322	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.439
ENSUAMP00000005136	KITLG	ENSUAMP00000005136	ENSUAMP00000030036	Uncharacterized protein.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.752
ENSUAMP00000006989	ENSUAMP00000009377	ENSUAMP00000006989	ENSUAMP00000009377	CTF/NF-I domain-containing protein.	Uncharacterized protein.	0.652
ENSUAMP00000006989	NF1	ENSUAMP00000006989	ENSUAMP00000024136	CTF/NF-I domain-containing protein.	Neurofibromin 1.	0.442
ENSUAMP00000009377	ENSUAMP00000001245	ENSUAMP00000009377	ENSUAMP00000001245	Uncharacterized protein.	CTF/NF-I domain-containing protein.	0.666
ENSUAMP00000009377	ENSUAMP00000006989	ENSUAMP00000009377	ENSUAMP00000006989	Uncharacterized protein.	CTF/NF-I domain-containing protein.	0.652
ENSUAMP00000009377	NF1	ENSUAMP00000009377	ENSUAMP00000024136	Uncharacterized protein.	Neurofibromin 1.	0.442
ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000017830	SOX17	ENSUAMP00000017830	ENSUAMP00000036659	Uncharacterized protein.	SRY-box transcription factor 17.	0.433
ENSUAMP00000025477	NF2	ENSUAMP00000025477	ENSUAMP00000019676	Uncharacterized protein.	Neurofibromin 2.	0.629
ENSUAMP00000025477	SFN	ENSUAMP00000025477	ENSUAMP00000034504	Uncharacterized protein.	Stratifin; Belongs to the 14-3-3 family.	0.731
ENSUAMP00000025477	TP53	ENSUAMP00000025477	ENSUAMP00000000913	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.574