STRINGSTRING
ENSUAMP00000006981 ENSUAMP00000006981 APC APC EGR1 EGR1 FRMD8 FRMD8 ENSUAMP00000000906 ENSUAMP00000000906 AXIN2 AXIN2 LATS2 LATS2 NOG NOG ENSUAMP00000001879 ENSUAMP00000001879 JADE1 JADE1 ENSUAMP00000002126 ENSUAMP00000002126 GREM1 GREM1 WNT11 WNT11 ENSUAMP00000003614 ENSUAMP00000003614 DKK1 DKK1 SFRP1 SFRP1 TMEM64 TMEM64 UBAC2 UBAC2 PRICKLE1 PRICKLE1 ENSUAMP00000005615 ENSUAMP00000005615 TMEM88 TMEM88 CHD8 CHD8 ENSUAMP00000006800 ENSUAMP00000006800 ENSUAMP00000006851 ENSUAMP00000006851 LATS1 LATS1 ENSUAMP00000006938 ENSUAMP00000006938 ENSUAMP00000006979 ENSUAMP00000006979 SHISA3 SHISA3 DKK3 DKK3 ENSUAMP00000007849 ENSUAMP00000007849 ENSUAMP00000007969 ENSUAMP00000007969 CAV1 CAV1 DKKL1 DKKL1 G3BP1 G3BP1 AMFR AMFR FZD4 FZD4 ENSUAMP00000010997 ENSUAMP00000010997 ENSUAMP00000011008 ENSUAMP00000011008 SFRP4 SFRP4 RAPGEF1 RAPGEF1 GSK3B GSK3B FOXO3 FOXO3 FOXO3B FOXO3B ENSUAMP00000012241 ENSUAMP00000012241 RUVBL2 RUVBL2 TPBG TPBG ENSUAMP00000013636 ENSUAMP00000013636 ENSUAMP00000014208 ENSUAMP00000014208 ENSUAMP00000014210 ENSUAMP00000014210 CBY1 CBY1 DAB2 DAB2 ENSUAMP00000015215 ENSUAMP00000015215 KREMEN1 KREMEN1 ENSUAMP00000015960 ENSUAMP00000015960 ENSUAMP00000016331 ENSUAMP00000016331 ANKRD6 ANKRD6 FERMT1 FERMT1 ENSUAMP00000016536 ENSUAMP00000016536 SOSTDC1 SOSTDC1 DKK2 DKK2 INVS INVS ENSUAMP00000017550 ENSUAMP00000017550 WWTR1 WWTR1 TLE4 TLE4 APC2 APC2 SNAI2 SNAI2 NKD2 NKD2 CTNNBIP1 CTNNBIP1 AXIN1 AXIN1 DKK4 DKK4 ENSUAMP00000021554 ENSUAMP00000021554 BMP2 BMP2 GPC3 GPC3 TNN TNN TMEM131L TMEM131L AMER1 AMER1 STK4 STK4 SDHAF2 SDHAF2 CTHRC1 CTHRC1 SOST SOST LZTS2 LZTS2 MAD2L2 MAD2L2 GLI1 GLI1 FRZB FRZB CSNK1A1 CSNK1A1 TMEM170B TMEM170B TCF7L2 TCF7L2 EMD EMD SOX10 SOX10 SOX9 SOX9 ENSUAMP00000026963 ENSUAMP00000026963 ENSUAMP00000027731 ENSUAMP00000027731 ENSUAMP00000027842 ENSUAMP00000027842 ENSUAMP00000027843 ENSUAMP00000027843 LRP4 LRP4 DAB2IP DAB2IP ENSUAMP00000028620 ENSUAMP00000028620 MCC MCC DACT1 DACT1 CYLD CYLD APOE APOE TLE3 TLE3 SLC9A3R1 SLC9A3R1 ENSUAMP00000031191 ENSUAMP00000031191 ENSUAMP00000031192 ENSUAMP00000031192 ENSUAMP00000031612 ENSUAMP00000031612 NPHP4 NPHP4 NOTUM NOTUM NKD1 NKD1 GLI3 GLI3 SOX13 SOX13 CTNND1 CTNND1 DDIT3 DDIT3 ENSUAMP00000034040 ENSUAMP00000034040 NOTCH1 NOTCH1 LMBR1L LMBR1L SIAH2 SIAH2 SCYL2 SCYL2 ENSUAMP00000036463 ENSUAMP00000036463 SOX17 SOX17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000006981Uncharacterized protein. (355 aa)
APCAPC regulator of WNT signaling pathway. (2832 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
FRMD8FERM domain containing 8. (463 aa)
ENSUAMP00000000906TLE_N domain-containing protein. (130 aa)
AXIN2Axin 2. (843 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ENSUAMP00000001879Protein kinase domain-containing protein. (335 aa)
JADE1Jade family PHD finger 1. (843 aa)
ENSUAMP00000002126zf-RING_14 domain-containing protein. (110 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENSUAMP00000003614Uncharacterized protein. (154 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (270 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
TMEM64Transmembrane protein 64. (402 aa)
UBAC2UBA domain containing 2. (227 aa)
PRICKLE1Prickle planar cell polarity protein 1. (832 aa)
ENSUAMP00000005615Uncharacterized protein. (177 aa)
TMEM88Transmembrane protein 88. (159 aa)
CHD8Chromodomain helicase DNA binding protein 8. (1832 aa)
ENSUAMP00000006800Uncharacterized protein. (97 aa)
ENSUAMP00000006851RBR-type E3 ubiquitin transferase. (137 aa)
LATS1Uncharacterized protein. (1012 aa)
ENSUAMP00000006938Uncharacterized protein. (133 aa)
ENSUAMP00000006979MAM domain-containing protein. (103 aa)
SHISA3Shisa family member 3. (238 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (361 aa)
ENSUAMP00000007849TLE_N domain-containing protein. (144 aa)
ENSUAMP00000007969Uncharacterized protein. (166 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
DKKL1Dickkopf like acrosomal protein 1. (233 aa)
G3BP1G3BP stress granule assembly factor 1. (465 aa)
AMFRAutocrine motility factor receptor. (620 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
ENSUAMP00000010997TPR_REGION domain-containing protein. (150 aa)
ENSUAMP00000011008Uncharacterized protein. (538 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1234 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
FOXO3Forkhead box O3. (453 aa)
FOXO3BForkhead box O3B. (244 aa)
ENSUAMP00000012241zf-RING_14 domain-containing protein. (109 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (525 aa)
TPBGTrophoblast glycoprotein. (419 aa)
ENSUAMP00000013636Uncharacterized protein. (265 aa)
ENSUAMP00000014208WD_REPEATS_REGION domain-containing protein. (574 aa)
ENSUAMP00000014210Uncharacterized protein. (379 aa)
CBY1Chibby family member 1, beta catenin antagonist. (127 aa)
DAB2DAB adaptor protein 2. (763 aa)
ENSUAMP00000015215Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa)
ENSUAMP00000015960Tyrosine-protein phosphatase domain-containing protein. (326 aa)
ENSUAMP00000016331Ubiquitin-like domain-containing protein. (153 aa)
ANKRD6Ankyrin repeat domain 6. (673 aa)
FERMT1Fermitin family member 1. (444 aa)
ENSUAMP00000016536Uncharacterized protein. (119 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
INVSInversin. (694 aa)
ENSUAMP00000017550Uncharacterized protein. (356 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
TLE4TLE family member 4, transcriptional corepressor. (702 aa)
APC2APC regulator of WNT signaling pathway 2. (2266 aa)
SNAI2Snail family transcriptional repressor 2. (230 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (450 aa)
CTNNBIP1Catenin beta interacting protein 1. (70 aa)
AXIN1Axin 1. (867 aa)
DKK4Dickkopf WNT signaling pathway inhibitor 4. (221 aa)
ENSUAMP00000021554Uncharacterized protein. (186 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
TNNTenascin N. (1408 aa)
TMEM131LTransmembrane 131 like. (1609 aa)
AMER1APC membrane recruitment protein 1. (1132 aa)
STK4Serine/threonine kinase 4. (487 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
CTHRC1Collagen triple helix repeat containing 1. (277 aa)
SOSTSclerostin. (213 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
GLI1GLI family zinc finger 1. (1105 aa)
FRZBFrizzled related protein. (298 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa)
TMEM170BTransmembrane protein 170B. (132 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
EMDEmerin. (260 aa)
SOX10SRY-box transcription factor 10. (465 aa)
SOX9SRY-box transcription factor 9. (484 aa)
ENSUAMP00000026963Protein kinase domain-containing protein. (93 aa)
ENSUAMP00000027731Kindlin_2_N domain-containing protein. (91 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
LRP4LDL receptor related protein 4. (1852 aa)
DAB2IPDAB2 interacting protein. (1100 aa)
ENSUAMP00000028620Uncharacterized protein. (106 aa)
MCCMCC regulator of WNT signaling pathway. (998 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (827 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
APOEApolipoprotein E. (323 aa)
TLE3TLE family member 3, transcriptional corepressor. (787 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
ENSUAMP00000031191Uncharacterized protein. (120 aa)
ENSUAMP00000031192Uncharacterized protein. (887 aa)
ENSUAMP00000031612TLE_N domain-containing protein. (92 aa)
NPHP4Nephrocystin 4. (1421 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (498 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (447 aa)
GLI3GLI family zinc finger 3. (1413 aa)
SOX13SRY-box transcription factor 13. (621 aa)
CTNND1Catenin delta 1. (961 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
ENSUAMP00000034040Uncharacterized protein. (92 aa)
NOTCH1Notch receptor 1. (2547 aa)
LMBR1LLimb development membrane protein 1 like. (317 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (325 aa)
SCYL2SCY1 like pseudokinase 2. (745 aa)
ENSUAMP00000036463TLE_N domain-containing protein. (120 aa)
SOX17SRY-box transcription factor 17. (406 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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