STRINGSTRING
KANK1 KANK1 ENSUAMP00000028824 ENSUAMP00000028824 ENSUAMP00000029322 ENSUAMP00000029322 DLX5 DLX5 DACT1 DACT1 CSNK1G1 CSNK1G1 SRC SRC ADGRA2 ADGRA2 TMEM198 TMEM198 USP8 USP8 CCAR2 CCAR2 ENSUAMP00000032909 ENSUAMP00000032909 GSKIP GSKIP ILK ILK CDH3 CDH3 ENSUAMP00000034574 ENSUAMP00000034574 RECK RECK ZBED3 ZBED3 RSPO3 RSPO3 RNF146 RNF146 WNT10B WNT10B ENSUAMP00000036162 ENSUAMP00000036162 LRRK1 LRRK1 ENSUAMP00000000198 ENSUAMP00000000198 LGR5 LGR5 XIAP XIAP ENSUAMP00000003944 ENSUAMP00000003944 SFRP1 SFRP1 FGF9 FGF9 TMEM9 TMEM9 RUVBL1 RUVBL1 FAM53B FAM53B USP47 USP47 FGF10 FGF10 CAV1 CAV1 ENSUAMP00000009120 ENSUAMP00000009120 SOX4 SOX4 ENSUAMP00000010247 ENSUAMP00000010247 PPM1A PPM1A SFRP4 SFRP4 PLEKHA4 PLEKHA4 HHEX HHEX WLS WLS GID8 GID8 NLE1 NLE1 CSNK1D CSNK1D ENSUAMP00000014507 ENSUAMP00000014507 ENSUAMP00000014514 ENSUAMP00000014514 LGR4 LGR4 ENSUAMP00000015412 ENSUAMP00000015412 PPM1M PPM1M LRRK2 LRRK2 TTC21B TTC21B ENSUAMP00000016276 ENSUAMP00000016276 TNKS TNKS DDX3X DDX3X DKK2 DKK2 ENSUAMP00000017407 ENSUAMP00000017407 RSPO1 RSPO1 ENSUAMP00000018294 ENSUAMP00000018294 CTDNEP1 CTDNEP1 TBL1XR1 TBL1XR1 PTK7 PTK7 JRK JRK ENSUAMP00000020805 ENSUAMP00000020805 FZD9 FZD9 TNKS2 TNKS2 GPC3 GPC3 BAMBI BAMBI LYPD6 LYPD6 AMER1 AMER1 ENSUAMP00000022718 ENSUAMP00000022718 ENSUAMP00000023035 ENSUAMP00000023035 PIN1 PIN1 SULF2 SULF2 ENSUAMP00000025477 ENSUAMP00000025477 ENSUAMP00000025718 ENSUAMP00000025718 PPM1N PPM1N NRARP NRARP ENSUAMP00000028015 ENSUAMP00000028015
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
ENSUAMP00000028824LSDAT_euk domain-containing protein. (181 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
DLX5Distal-less homeobox 5. (289 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (827 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (499 aa)
SRCTyrosine-protein kinase. (557 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1327 aa)
TMEM198Transmembrane protein 198. (360 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1116 aa)
CCAR2Cell cycle and apoptosis regulator 2. (918 aa)
ENSUAMP00000032909Uncharacterized protein. (592 aa)
GSKIPGSK3B interacting protein. (153 aa)
ILKIntegrin linked kinase. (503 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (856 aa)
ENSUAMP00000034574Uncharacterized protein. (525 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
ZBED3Zinc finger BED-type containing 3. (210 aa)
RSPO3R-spondin 3. (275 aa)
RNF146Ring finger protein 146. (362 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ENSUAMP00000036162Protein kinase domain-containing protein. (462 aa)
LRRK1Leucine rich repeat kinase 1. (2014 aa)
ENSUAMP00000000198Uncharacterized protein. (238 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
ENSUAMP00000003944PPM-type phosphatase domain-containing protein. (479 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TMEM9Transmembrane protein 9. (197 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
FAM53BFamily with sequence similarity 53 member B. (426 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1275 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ENSUAMP00000009120Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (436 aa)
SOX4Transcription factor SOX. (452 aa)
ENSUAMP00000010247Uncharacterized protein. (234 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
PLEKHA4Pleckstrin homology domain containing A4. (774 aa)
HHEXHematopoietically expressed homeobox. (270 aa)
WLSWnt ligand secretion mediator. (484 aa)
GID8GID complex subunit 8 homolog. (228 aa)
NLE1Notchless homolog 1. (477 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (428 aa)
ENSUAMP00000014507RING-type domain-containing protein. (245 aa)
ENSUAMP00000014514RNF220 domain-containing protein. (104 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (971 aa)
ENSUAMP00000015412C1q domain-containing protein. (490 aa)
PPM1MProtein phosphatase, Mg2+/Mn2+ dependent 1M. (255 aa)
LRRK2Leucine rich repeat kinase 2. (1967 aa)
TTC21BTetratricopeptide repeat domain 21B. (1268 aa)
ENSUAMP00000016276Uncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
TNKSPoly [ADP-ribose] polymerase. (908 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
ENSUAMP00000017407Uncharacterized protein. (216 aa)
RSPO1R-spondin 1. (263 aa)
ENSUAMP00000018294DUF4203 domain-containing protein. (350 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (520 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
JRKJrk helix-turn-helix protein. (541 aa)
ENSUAMP00000020805UBR-type domain-containing protein. (2331 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
TNKS2Poly [ADP-ribose] polymerase. (1276 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LYPD6LY6/PLAUR domain containing 6. (89 aa)
AMER1APC membrane recruitment protein 1. (1132 aa)
ENSUAMP00000022718USP domain-containing protein; Belongs to the peptidase C19 family. (1809 aa)
ENSUAMP00000023035Uncharacterized protein. (527 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
ENSUAMP00000025718Uncharacterized protein. (489 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (407 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ENSUAMP00000028015LIM zinc-binding domain-containing protein. (383 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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