(30 nodes) Cellular senescence network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBX2	T-box transcription factor 2. (697 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	ENSUAMP00000002092	Uncharacterized protein. (63 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1044 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	ECRG4	ECRG4 augurin precursor. (122 aa)
	PML	Promyelocytic leukemia. (877 aa)
	MNT	MAX network transcriptional repressor. (547 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1559 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	ENSUAMP00000028320	Nsp1_C domain-containing protein. (184 aa)
	WRN	WRN RecQ like helicase. (1363 aa)
	ENSUAMP00000025721	Uncharacterized protein. (113 aa)
	NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (157 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	SIRT1	Sirtuin 1. (618 aa)
	SRF	Serum response factor. (507 aa)
	HMGA1	High mobility group AT-hook 1. (107 aa)
	BRCA2	BRCA2 DNA repair associated. (3458 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (671 aa)
	ENSUAMP00000012508	SMC_N domain-containing protein. (1106 aa)
	KAT6A	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2004 aa)
	ABL1	Tyrosine-protein kinase. (1138 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (379 aa)
	ENSUAMP00000002099	AAA_23 domain-containing protein. (1035 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (456 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CDKN1A	ENSUAMP00000009706	ENSUAMP00000028410	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.533
ABL1	TP53	ENSUAMP00000009706	ENSUAMP00000000913	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.515
BRCA2	TP53	ENSUAMP00000017844	ENSUAMP00000000913	BRCA2 DNA repair associated.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.895
BRCA2	TP63	ENSUAMP00000017844	ENSUAMP00000007724	BRCA2 DNA repair associated.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.476
BRCA2	WRN	ENSUAMP00000017844	ENSUAMP00000027574	BRCA2 DNA repair associated.	WRN RecQ like helicase.	0.959
CDKN1A	ABL1	ENSUAMP00000028410	ENSUAMP00000009706	Cyclin dependent kinase inhibitor 1A.	Tyrosine-protein kinase.	0.533
CDKN1A	TP53	ENSUAMP00000028410	ENSUAMP00000000913	Cyclin dependent kinase inhibitor 1A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.948
CDKN1A	TP63	ENSUAMP00000028410	ENSUAMP00000007724	Cyclin dependent kinase inhibitor 1A.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.474
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000002092	ENSUAMP00000012508	ENSUAMP00000002092	ENSUAMP00000012508	Uncharacterized protein.	SMC_N domain-containing protein.	0.978
ENSUAMP00000002092	NSMCE2	ENSUAMP00000002092	ENSUAMP00000023499	Uncharacterized protein.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.964
ENSUAMP00000002092	WRN	ENSUAMP00000002092	ENSUAMP00000027574	Uncharacterized protein.	WRN RecQ like helicase.	0.748
ENSUAMP00000002099	ENSUAMP00000012508	ENSUAMP00000002099	ENSUAMP00000012508	AAA_23 domain-containing protein.	SMC_N domain-containing protein.	0.978
ENSUAMP00000002099	NSMCE2	ENSUAMP00000002099	ENSUAMP00000023499	AAA_23 domain-containing protein.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.964
ENSUAMP00000002099	WRN	ENSUAMP00000002099	ENSUAMP00000027574	AAA_23 domain-containing protein.	WRN RecQ like helicase.	0.748
ENSUAMP00000012508	ENSUAMP00000002092	ENSUAMP00000012508	ENSUAMP00000002092	SMC_N domain-containing protein.	Uncharacterized protein.	0.978
ENSUAMP00000012508	ENSUAMP00000002099	ENSUAMP00000012508	ENSUAMP00000002099	SMC_N domain-containing protein.	AAA_23 domain-containing protein.	0.978
ENSUAMP00000012508	NSMCE2	ENSUAMP00000012508	ENSUAMP00000023499	SMC_N domain-containing protein.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.997
ENSUAMP00000012508	WRN	ENSUAMP00000012508	ENSUAMP00000027574	SMC_N domain-containing protein.	WRN RecQ like helicase.	0.824
ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	Uncharacterized protein.	Uncharacterized protein.	0.671