STRINGSTRING
HIPK1 HIPK1 ERN2 ERN2 IVNS1ABP IVNS1ABP ENSUAMP00000026963 ENSUAMP00000026963 TOPORS TOPORS SMAD3 SMAD3 PTGIS PTGIS ATP2A1 ATP2A1 IFI6 IFI6 ENSUAMP00000025829 ENSUAMP00000025829 ENSUAMP00000025828 ENSUAMP00000025828 TIMM50 TIMM50 BDKRB2 BDKRB2 ENSUAMP00000025477 ENSUAMP00000025477 ENSUAMP00000025110 ENSUAMP00000025110 CTTN CTTN ENSUAMP00000024386 ENSUAMP00000024386 SHISA5 SHISA5 NF1 NF1 IL18 IL18 MAEL MAEL ENSUAMP00000023390 ENSUAMP00000023390 NBN NBN BCL3 BCL3 ENSUAMP00000022738 ENSUAMP00000022738 QRICH1 QRICH1 CD5 CD5 CASP9 CASP9 STK4 STK4 IL7 IL7 PDCD10 PDCD10 SIRT1 SIRT1 TNF TNF RB1CC1 RB1CC1 CHAC1 CHAC1 DDX47 DDX47 G0S2 G0S2 TGFB2 TGFB2 CASP3 CASP3 ENSUAMP00000020568 ENSUAMP00000020568 ENSUAMP00000020564 ENSUAMP00000020564 FIS1 FIS1 ERCC6 ERCC6 ENSUAMP00000020431 ENSUAMP00000020431 EYA1 EYA1 NOL3 NOL3 TRADD TRADD RIPK1 RIPK1 TLR3 TLR3 BAD BAD SKIL SKIL CYP1B1 CYP1B1 PDIA3 PDIA3 EPHA2 EPHA2 MCL1 MCL1 DNM1L DNM1L ENSUAMP00000018082 ENSUAMP00000018082 PPARD PPARD BRCA2 BRCA2 ENSUAMP00000017736 ENSUAMP00000017736 ATP2A3 ATP2A3 MSH2 MSH2 MSH6 MSH6 ENSUAMP00000017677 ENSUAMP00000017677 ACVR1B ACVR1B ENSUAMP00000017468 ENSUAMP00000017468 STK26 STK26 ENSUAMP00000016713 ENSUAMP00000016713 DDX3X DDX3X PDPK1 PDPK1 ENSUAMP00000016276 ENSUAMP00000016276 RHOT2 RHOT2 ERBB3 ERBB3 PPM1F PPM1F AIFM1 AIFM1 ADORA2A ADORA2A BAX BAX UACA UACA RNF186 RNF186 NUPR1 NUPR1 TGFB1 TGFB1 FOXO3B FOXO3B FOXO3 FOXO3 GSK3B GSK3B ENSUAMP00000012080 ENSUAMP00000012080 BCL2 BCL2 BAG3 BAG3 ENSUAMP00000011731 ENSUAMP00000011731 BNIP3 BNIP3 DDIT4 DDIT4 DAPL1 DAPL1 FGFR3 FGFR3 PRKDC PRKDC SIVA1 SIVA1 TP53BP2 TP53BP2 ENSUAMP00000010575 ENSUAMP00000010575 PIK3R1 PIK3R1 PYCARD PYCARD BOK BOK STK25 STK25 ATF2 ATF2 ABL1 ABL1 ERN1 ERN1 ENSUAMP00000008823 ENSUAMP00000008823 CAV1 CAV1 ENSUAMP00000000343 ENSUAMP00000000343 INCA1 INCA1 BAK1 BAK1 NDUFA13 NDUFA13 YJEFN3 YJEFN3 TP53 TP53 SGPL1 SGPL1 HIPK2 HIPK2 ENSUAMP00000001579 ENSUAMP00000001579 ENSUAMP00000001661 ENSUAMP00000001661 ENSUAMP00000001879 ENSUAMP00000001879 RHOT1 RHOT1 ITPRIP ITPRIP ENSUAMP00000003468 ENSUAMP00000003468 ENSUAMP00000003796 ENSUAMP00000003796 ENSUAMP00000003860 ENSUAMP00000003860 CD3E CD3E TNFSF12 TNFSF12 SFRP1 SFRP1 ENSUAMP00000004351 ENSUAMP00000004351 E2F2 E2F2 ATF4 ATF4 TRIB3 TRIB3 ENSUAMP00000004964 ENSUAMP00000004964 RNF41 RNF41 ENSUAMP00000005304 ENSUAMP00000005304 PHLDA3 PHLDA3 CDIP1 CDIP1 TFPT TFPT ENSUAMP00000006279 ENSUAMP00000006279 FAIM2 FAIM2 ENSUAMP00000006566 ENSUAMP00000006566 ENSUAMP00000006699 ENSUAMP00000006699 ENSUAMP00000006800 ENSUAMP00000006800 P2RX4 P2RX4 P2RX7 P2RX7 USP47 USP47 INHBA INHBA MAP3K5 MAP3K5 TP63 TP63 PAWR PAWR MELK MELK NANOS3 NANOS3 ENSUAMP00000007969 ENSUAMP00000007969 ENSUAMP00000007992 ENSUAMP00000007992 CASP10 CASP10 CASP8 CASP8 NFATC4 NFATC4 FGF10 FGF10 ENSUAMP00000013528 ENSUAMP00000013528 ENSUAMP00000013655 ENSUAMP00000013655 DIDO1 DIDO1 CHEK2 CHEK2 PARP2 PARP2 TMEM109 TMEM109 BNIP3L BNIP3L DEDD2 DEDD2 ENSUAMP00000014717 ENSUAMP00000014717 CLU CLU TP73 TP73 COA8 COA8 ENSUAMP00000015093 ENSUAMP00000015093 ENSUAMP00000015102 ENSUAMP00000015102 ENSUAMP00000015215 ENSUAMP00000015215 HIP1 HIP1 BAG6 BAG6 CASP8AP2 CASP8AP2 UBE4B UBE4B ENSUAMP00000037288 ENSUAMP00000037288 PCGF2 PCGF2 ENSUAMP00000036961 ENSUAMP00000036961 ENSUAMP00000036338 ENSUAMP00000036338 MLLT11 MLLT11 PMAIP1 PMAIP1 DAXX DAXX PDK2 PDK2 TM2D1 TM2D1 ENSUAMP00000035281 ENSUAMP00000035281 TMEM117 TMEM117 NOX1 NOX1 ENSUAMP00000035027 ENSUAMP00000035027 ENSUAMP00000034850 ENSUAMP00000034850 ENSUAMP00000034830 ENSUAMP00000034830 E2F1 E2F1 SFN SFN RRP8 RRP8 GSKIP GSKIP DDIT3 DDIT3 TNFRSF1B TNFRSF1B DEDD DEDD ENSUAMP00000033348 ENSUAMP00000033348 ENSUAMP00000033323 ENSUAMP00000033323 PML PML ELL3 ELL3 HIC1 HIC1 BCL2A1 BCL2A1 JMY JMY CASP6 CASP6 BCL2L2 BCL2L2 PABPN1 PABPN1 EP300 EP300 DELE1 DELE1 PDK1 PDK1 MYC MYC NGF NGF RETREG1 RETREG1 ENSUAMP00000031523 ENSUAMP00000031523 ZNF622 ZNF622 ITPRIPL2 ITPRIPL2 MYBBP1A MYBBP1A ENSUAMP00000030787 ENSUAMP00000030787 RAF1 RAF1 DYRK2 DYRK2 BCL2L1 BCL2L1 ANXA6 ANXA6 ITGAV ITGAV ENSUAMP00000030460 ENSUAMP00000030460 DDX5 DDX5 PDX1 PDX1 KITLG KITLG ENSUAMP00000030033 ENSUAMP00000030033 ENSUAMP00000029915 ENSUAMP00000029915 BCL2L11 BCL2L11 IKBKE IKBKE IL2 IL2 TNFRSF1A TNFRSF1A CD27 CD27 SNW1 SNW1 MAPK9 MAPK9 PIDD1 PIDD1 KRT18 KRT18 DAB2IP DAB2IP SORT1 SORT1 CDKN1A CDKN1A ENSUAMP00000028265 ENSUAMP00000028265 HTRA2 HTRA2 CD28 CD28 FADD FADD CEBPB CEBPB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HIPK1Homeodomain interacting protein kinase 1. (822 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (905 aa)
IVNS1ABPInfluenza virus NS1A binding protein. (642 aa)
ENSUAMP00000026963Protein kinase domain-containing protein. (93 aa)
TOPORSTOP1 binding arginine/serine rich protein. (976 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (499 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1060 aa)
IFI6Interferon alpha inducible protein 6. (143 aa)
ENSUAMP00000025829CARD domain-containing protein. (86 aa)
ENSUAMP00000025828Uncharacterized protein; Belongs to the peptidase C14A family. (317 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (344 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (392 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
ENSUAMP00000025110Uncharacterized protein. (88 aa)
CTTNCortactin. (502 aa)
ENSUAMP00000024386Exonuclease domain-containing protein. (175 aa)
SHISA5Shisa family member 5. (238 aa)
NF1Neurofibromin 1. (2845 aa)
IL18Interleukin 18. (167 aa)
MAELMaelstrom spermatogenic transposon silencer. (434 aa)
ENSUAMP00000023390Uncharacterized protein. (286 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
BCL3BCL3 transcription coactivator. (424 aa)
ENSUAMP00000022738Uncharacterized protein. (126 aa)
QRICH1Glutamine rich 1. (418 aa)
CD5CD5 molecule. (468 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
STK4Serine/threonine kinase 4. (487 aa)
IL7Interleukin 7. (152 aa)
PDCD10Programmed cell death 10. (212 aa)
SIRT1Sirtuin 1. (618 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
RB1CC1RB1 inducible coiled-coil 1. (1273 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (234 aa)
DDX47DEAD-box helicase 47; Belongs to the DEAD box helicase family. (457 aa)
G0S2G0/G1 switch 2. (103 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
ENSUAMP00000020568DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (181 aa)
ENSUAMP00000020564HHH_8 domain-containing protein. (107 aa)
FIS1Fission, mitochondrial 1. (166 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1482 aa)
ENSUAMP00000020431Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
NOL3Nucleolar protein 3. (222 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
BADBCL2 associated agonist of cell death. (168 aa)
SKILSKI like proto-oncogene. (684 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
PDIA3Protein disulfide-isomerase. (460 aa)
EPHA2EPH receptor A2. (966 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (736 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
BRCA2BRCA2 DNA repair associated. (3458 aa)
ENSUAMP00000017736Cation_ATPase_N domain-containing protein. (54 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (982 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1260 aa)
ENSUAMP00000017677Uncharacterized protein; Belongs to the BI1 family. (285 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
ENSUAMP00000017468Protein kinase domain-containing protein. (85 aa)
STK26Serine/threonine kinase 26. (416 aa)
ENSUAMP00000016713Uncharacterized protein; Belongs to the peptidase C14A family. (195 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
ENSUAMP00000016276Uncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
RHOT2Ras homolog family member T2. (919 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1281 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (441 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (594 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1399 aa)
RNF186Ring finger protein 186. (228 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FOXO3BForkhead box O3B. (244 aa)
FOXO3Forkhead box O3. (453 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
ENSUAMP00000012080Uncharacterized protein; Belongs to the peptidase C14A family. (409 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
BAG3BCL2 associated athanogene 3. (578 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
BNIP3BCL2 interacting protein 3. (263 aa)
DDIT4DNA damage inducible transcript 4. (231 aa)
DAPL1Death associated protein like 1. (101 aa)
FGFR3Fibroblast growth factor receptor. (691 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3341 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
TP53BP2Tumor protein p53 binding protein 2. (1157 aa)
ENSUAMP00000010575Uncharacterized protein. (237 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
PYCARDPYD and CARD domain containing. (194 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
STK25Serine/threonine kinase 25. (426 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ABL1Tyrosine-protein kinase. (1138 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
ENSUAMP00000008823TAN domain-containing protein. (111 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ENSUAMP00000000343HIT domain-containing protein. (67 aa)
INCA1Inhibitor of CDK, cyclin A1 interacting protein 1. (245 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
YJEFN3YjeF N-terminal domain-containing protein. (250 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
HIPK2Homeodomain interacting protein kinase 2. (1200 aa)
ENSUAMP00000001579Cation_ATPase_N domain-containing protein. (75 aa)
ENSUAMP00000001661TGF_BETA_2 domain-containing protein. (194 aa)
ENSUAMP00000001879Protein kinase domain-containing protein. (335 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (633 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (552 aa)
ENSUAMP00000003468Uncharacterized protein. (146 aa)
ENSUAMP00000003796C2H2-type domain-containing protein. (240 aa)
ENSUAMP00000003860Uncharacterized protein. (146 aa)
CD3ECD3e molecule. (207 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (218 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
ENSUAMP00000004351CARD domain-containing protein. (165 aa)
E2F2E2F transcription factor 2. (431 aa)
ATF4Activating transcription factor 4. (351 aa)
TRIB3Tribbles pseudokinase 3. (363 aa)
ENSUAMP00000004964Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
RNF41Ring finger protein 41. (246 aa)
ENSUAMP00000005304Uncharacterized protein. (197 aa)
PHLDA3Pleckstrin homology like domain family A member 3. (125 aa)
CDIP1Cell death inducing p53 target 1. (208 aa)
TFPTTCF3 fusion partner. (253 aa)
ENSUAMP00000006279Galectin. (299 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
ENSUAMP00000006566UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
ENSUAMP00000006699Uncharacterized protein. (409 aa)
ENSUAMP00000006800Uncharacterized protein. (97 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (401 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (578 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1275 aa)
INHBAInhibin subunit beta A. (424 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1212 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PAWRPro-apoptotic WT1 regulator. (343 aa)
MELKNon-specific serine/threonine protein kinase. (642 aa)
NANOS3Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (174 aa)
ENSUAMP00000007969Uncharacterized protein. (166 aa)
ENSUAMP00000007992Uncharacterized protein. (219 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
NFATC4Nuclear factor of activated T cells 4. (911 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
ENSUAMP00000013528U1-type domain-containing protein. (104 aa)
ENSUAMP00000013655annotation not available (67 aa)
DIDO1Death inducer-obliterator 1. (2210 aa)
CHEK2Checkpoint kinase 2. (530 aa)
PARP2Poly [ADP-ribose] polymerase. (568 aa)
TMEM109Transmembrane protein 109. (231 aa)
BNIP3LBCL2 interacting protein 3 like. (221 aa)
DEDD2Death effector domain containing 2. (327 aa)
ENSUAMP00000014717Uncharacterized protein. (131 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (446 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
COA8Cytochrome c oxidase assembly factor 8. (193 aa)
ENSUAMP00000015093Uncharacterized protein. (1064 aa)
ENSUAMP00000015102Uncharacterized protein. (121 aa)
ENSUAMP00000015215Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
HIP1Huntingtin interacting protein 1. (681 aa)
BAG6BCL2 associated athanogene 6. (1164 aa)
CASP8AP2Caspase 8 associated protein 2. (1994 aa)
UBE4BUbiquitination factor E4B. (1236 aa)
ENSUAMP00000037288Uncharacterized protein. (95 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
ENSUAMP00000036961Uncharacterized protein. (86 aa)
ENSUAMP00000036338Uncharacterized protein. (747 aa)
MLLT11MLLT11 transcription factor 7 cofactor. (89 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
DAXXDeath domain associated protein. (756 aa)
PDK2Protein-serine/threonine kinase. (249 aa)
TM2D1TM2 domain containing 1. (201 aa)
ENSUAMP00000035281ULP_PROTEASE domain-containing protein. (102 aa)
TMEM117Transmembrane protein 117. (391 aa)
NOX1NADPH oxidase 1. (594 aa)
ENSUAMP00000035027Uncharacterized protein. (146 aa)
ENSUAMP00000034850Uncharacterized protein. (294 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
E2F1E2F transcription factor 1. (400 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (457 aa)
GSKIPGSK3B interacting protein. (153 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
TNFRSF1BTNF receptor superfamily member 1B. (460 aa)
DEDDDeath effector domain containing. (318 aa)
ENSUAMP00000033348Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (231 aa)
ENSUAMP00000033323CARD domain-containing protein. (221 aa)
PMLPromyelocytic leukemia. (877 aa)
ELL3Elongation factor for RNA polymerase II 3. (414 aa)
HIC1HIC ZBTB transcriptional repressor 1. (713 aa)
BCL2A1BCL2 related protein A1. (174 aa)
JMYJunction mediating and regulatory protein, p53 cofactor. (978 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
BCL2L2BCL2 like 2. (193 aa)
PABPN1RRM domain-containing protein. (306 aa)
EP300E1A binding protein p300. (2399 aa)
DELE1Uncharacterized protein. (340 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (240 aa)
RETREG1Reticulophagy regulator 1. (277 aa)
ENSUAMP00000031523annotation not available (299 aa)
ZNF622Zinc finger protein 622. (471 aa)
ITPRIPL2ITPRIP like 2. (532 aa)
MYBBP1AMYB binding protein 1a. (1318 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
BCL2L1BCL2 like 1. (233 aa)
ANXA6Annexin. (673 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
ENSUAMP00000030460WW domain-containing protein. (139 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
ENSUAMP00000030033Uncharacterized protein. (274 aa)
ENSUAMP00000029915Uncharacterized protein. (90 aa)
BCL2L11BCL2 like 11. (140 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
CD27CD27 molecule. (231 aa)
SNW1SNW domain containing 1. (511 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
PIDD1P53-induced death domain protein 1. (911 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (443 aa)
DAB2IPDAB2 interacting protein. (1100 aa)
SORT1Sortilin. (829 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSUAMP00000028265RING-type domain-containing protein. (357 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
CD28CD28 molecule. (216 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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