(92 nodes) Extrinsic apoptotic signaling pathway network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	NDUFA13	NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
	YJEFN3	YjeF N-terminal domain-containing protein. (250 aa)
	ITPRIP	Inositol 1,4,5-trisphosphate receptor interacting protein. (552 aa)
	TNFSF12	TNF superfamily member 12; Belongs to the tumor necrosis factor family. (218 aa)
	SFRP1	Secreted frizzled related protein 1. (337 aa)
	ENSUAMP00000004351	CARD domain-containing protein. (165 aa)
	RNF41	Ring finger protein 41. (246 aa)
	ENSUAMP00000005304	Uncharacterized protein. (197 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (578 aa)
	INHBA	Inhibin subunit beta A. (424 aa)
	ENSUAMP00000007969	Uncharacterized protein. (166 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (481 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (395 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
	SIVA1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
	FGFR3	Fibroblast growth factor receptor. (691 aa)
	BAG3	BCL2 associated athanogene 3. (578 aa)
	BCL2	BCL2 apoptosis regulator. (205 aa)
	GSK3B	Glycogen synthase kinase 3 beta. (335 aa)
	FOXO3	Forkhead box O3. (453 aa)
	FOXO3B	Forkhead box O3B. (244 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	BAX	BCL2 associated X, apoptosis regulator. (205 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1281 aa)
	PARP2	Poly [ADP-ribose] polymerase. (568 aa)
	ENSUAMP00000015215	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
	CASP8AP2	Caspase 8 associated protein 2. (1994 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
	ENSUAMP00000016276	Uncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (531 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
	ENSUAMP00000017468	Protein kinase domain-containing protein. (85 aa)
	ACVR1B	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
	ENSUAMP00000018082	Uncharacterized protein. (249 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	DEDD2	Death effector domain containing 2. (327 aa)
	PDIA3	Protein disulfide-isomerase. (460 aa)
	SKIL	SKI like proto-oncogene. (684 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (550 aa)
	TRADD	TNFRSF1A associated via death domain. (314 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	ENSUAMP00000020431	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
	G0S2	G0/G1 switch 2. (103 aa)
	DDX47	DEAD-box helicase 47; Belongs to the DEAD box helicase family. (457 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1273 aa)
	IL7	Interleukin 7. (152 aa)
	STK4	Serine/threonine kinase 4. (487 aa)
	ENSUAMP00000022738	Uncharacterized protein. (126 aa)
	IL18	Interleukin 18. (167 aa)
	NF1	Neurofibromin 1. (2845 aa)
	CTTN	Cortactin. (502 aa)
	ENSUAMP00000025110	Uncharacterized protein. (88 aa)
	ENSUAMP00000025477	Uncharacterized protein. (185 aa)
	ENSUAMP00000025828	Uncharacterized protein; Belongs to the peptidase C14A family. (317 aa)
	ENSUAMP00000025829	CARD domain-containing protein. (86 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ENSUAMP00000026963	Protein kinase domain-containing protein. (93 aa)
	HIPK1	Homeodomain interacting protein kinase 1. (822 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
	SORT1	Sortilin. (829 aa)
	DAB2IP	DAB2 interacting protein. (1100 aa)
	KRT18	Keratin 18; Belongs to the intermediate filament family. (443 aa)
	PIDD1	P53-induced death domain protein 1. (911 aa)
	CD27	CD27 molecule. (231 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	BCL2L11	BCL2 like 11. (140 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
	ENSUAMP00000030460	WW domain-containing protein. (139 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
	ENSUAMP00000030787	Uncharacterized protein. (84 aa)
	ITPRIPL2	ITPRIP like 2. (532 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (240 aa)
	DELE1	Uncharacterized protein. (340 aa)
	PABPN1	RRM domain-containing protein. (306 aa)
	BCL2L2	BCL2 like 2. (193 aa)
	BCL2A1	BCL2 related protein A1. (174 aa)
	PML	Promyelocytic leukemia. (877 aa)
	ENSUAMP00000033348	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (231 aa)
	DEDD	Death effector domain containing. (318 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (460 aa)
	DAXX	Death domain associated protein. (756 aa)
	MLLT11	MLLT11 transcription factor 7 cofactor. (89 aa)
	ENSUAMP00000036338	Uncharacterized protein. (747 aa)
	ENSUAMP00000037288	Uncharacterized protein. (95 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1B	INHBA	ENSUAMP00000017512	ENSUAMP00000007348	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Inhibin subunit beta A.	0.996
ACVR1B	SMAD3	ENSUAMP00000017512	ENSUAMP00000026563	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.986
ACVR1B	TGFB1	ENSUAMP00000017512	ENSUAMP00000012487	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.778
ACVR1B	TGFB2	ENSUAMP00000017512	ENSUAMP00000020781	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.580
BAD	BAK1	ENSUAMP00000019222	ENSUAMP00000000602	BCL2 associated agonist of cell death.	BCL2 antagonist/killer 1.	0.846
BAD	BAX	ENSUAMP00000019222	ENSUAMP00000013214	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.854
BAD	BCL2	ENSUAMP00000019222	ENSUAMP00000011868	BCL2 associated agonist of cell death.	BCL2 apoptosis regulator.	0.994
BAD	BCL2A1	ENSUAMP00000019222	ENSUAMP00000032447	BCL2 associated agonist of cell death.	BCL2 related protein A1.	0.777
BAD	BCL2L1	ENSUAMP00000019222	ENSUAMP00000030600	BCL2 associated agonist of cell death.	BCL2 like 1.	0.998
BAD	BCL2L11	ENSUAMP00000019222	ENSUAMP00000029698	BCL2 associated agonist of cell death.	BCL2 like 11.	0.914
BAD	BCL2L2	ENSUAMP00000019222	ENSUAMP00000031955	BCL2 associated agonist of cell death.	BCL2 like 2.	0.911
BAD	BOK	ENSUAMP00000019222	ENSUAMP00000010294	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.821
BAD	ENSUAMP00000004351	ENSUAMP00000019222	ENSUAMP00000004351	BCL2 associated agonist of cell death.	CARD domain-containing protein.	0.457
BAD	ENSUAMP00000005304	ENSUAMP00000019222	ENSUAMP00000005304	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.889
BAD	ENSUAMP00000025828	ENSUAMP00000019222	ENSUAMP00000025828	BCL2 associated agonist of cell death.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.457
BAD	ENSUAMP00000025829	ENSUAMP00000019222	ENSUAMP00000025829	BCL2 associated agonist of cell death.	CARD domain-containing protein.	0.457
BAD	ENSUAMP00000030787	ENSUAMP00000019222	ENSUAMP00000030787	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.912
BAD	FADD	ENSUAMP00000019222	ENSUAMP00000027565	BCL2 associated agonist of cell death.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.537
BAD	MCL1	ENSUAMP00000019222	ENSUAMP00000018533	BCL2 associated agonist of cell death.	MCL1 apoptosis regulator, BCL2 family member.	0.798
BAD	RAF1	ENSUAMP00000019222	ENSUAMP00000030761	BCL2 associated agonist of cell death.	Raf-1 proto-oncogene, serine/threonine kinase.	0.912