(32 nodes) Extrinsic apoptotic signaling pathway in absence of ligand network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	FOXO3B	Forkhead box O3B. (244 aa)
	BAX	BCL2 associated X, apoptosis regulator. (205 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1281 aa)
	ENSUAMP00000015215	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
	ENSUAMP00000018082	Uncharacterized protein. (249 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	GSK3B	Glycogen synthase kinase 3 beta. (335 aa)
	BCL2	BCL2 apoptosis regulator. (205 aa)
	BAG3	BCL2 associated athanogene 3. (578 aa)
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	ENSUAMP00000005304	Uncharacterized protein. (197 aa)
	ENSUAMP00000004351	CARD domain-containing protein. (165 aa)
	FOXO3	Forkhead box O3. (453 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	ENSUAMP00000020431	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
	NF1	Neurofibromin 1. (2845 aa)
	ENSUAMP00000025828	Uncharacterized protein; Belongs to the peptidase C14A family. (317 aa)
	ENSUAMP00000025829	CARD domain-containing protein. (86 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	BCL2L11	BCL2 like 11. (140 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	PABPN1	RRM domain-containing protein. (306 aa)
	BCL2L2	BCL2 like 2. (193 aa)
	BCL2A1	BCL2 related protein A1. (174 aa)
	ENSUAMP00000033348	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (231 aa)
	ENSUAMP00000037288	Uncharacterized protein. (95 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAD	BAK1	ENSUAMP00000019222	ENSUAMP00000000602	BCL2 associated agonist of cell death.	BCL2 antagonist/killer 1.	0.846
BAD	BAX	ENSUAMP00000019222	ENSUAMP00000013214	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.854
BAD	BCL2	ENSUAMP00000019222	ENSUAMP00000011868	BCL2 associated agonist of cell death.	BCL2 apoptosis regulator.	0.994
BAD	BCL2A1	ENSUAMP00000019222	ENSUAMP00000032447	BCL2 associated agonist of cell death.	BCL2 related protein A1.	0.777
BAD	BCL2L1	ENSUAMP00000019222	ENSUAMP00000030600	BCL2 associated agonist of cell death.	BCL2 like 1.	0.998
BAD	BCL2L11	ENSUAMP00000019222	ENSUAMP00000029698	BCL2 associated agonist of cell death.	BCL2 like 11.	0.914
BAD	BCL2L2	ENSUAMP00000019222	ENSUAMP00000031955	BCL2 associated agonist of cell death.	BCL2 like 2.	0.911
BAD	BOK	ENSUAMP00000019222	ENSUAMP00000010294	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.821
BAD	ENSUAMP00000004351	ENSUAMP00000019222	ENSUAMP00000004351	BCL2 associated agonist of cell death.	CARD domain-containing protein.	0.457
BAD	ENSUAMP00000005304	ENSUAMP00000019222	ENSUAMP00000005304	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.889
BAD	ENSUAMP00000025828	ENSUAMP00000019222	ENSUAMP00000025828	BCL2 associated agonist of cell death.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.457
BAD	ENSUAMP00000025829	ENSUAMP00000019222	ENSUAMP00000025829	BCL2 associated agonist of cell death.	CARD domain-containing protein.	0.457
BAD	FADD	ENSUAMP00000019222	ENSUAMP00000027565	BCL2 associated agonist of cell death.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.537
BAD	MCL1	ENSUAMP00000019222	ENSUAMP00000018533	BCL2 associated agonist of cell death.	MCL1 apoptosis regulator, BCL2 family member.	0.798
BAG3	BCL2	ENSUAMP00000011732	ENSUAMP00000011868	BCL2 associated athanogene 3.	BCL2 apoptosis regulator.	0.767
BAG3	BOK	ENSUAMP00000011732	ENSUAMP00000010294	BCL2 associated athanogene 3.	BCL2 family apoptosis regulator BOK.	0.407
BAK1	BAD	ENSUAMP00000000602	ENSUAMP00000019222	BCL2 antagonist/killer 1.	BCL2 associated agonist of cell death.	0.846
BAK1	BAX	ENSUAMP00000000602	ENSUAMP00000013214	BCL2 antagonist/killer 1.	BCL2 associated X, apoptosis regulator.	0.975
BAK1	BCL2	ENSUAMP00000000602	ENSUAMP00000011868	BCL2 antagonist/killer 1.	BCL2 apoptosis regulator.	0.990
BAK1	BCL2A1	ENSUAMP00000000602	ENSUAMP00000032447	BCL2 antagonist/killer 1.	BCL2 related protein A1.	0.949