STRINGSTRING
CASP9 CASP9 ENSUAMP00000033283 ENSUAMP00000033283 BAD BAD LGMN LGMN ENSUAMP00000002418 ENSUAMP00000002418 BAK1 BAK1 PYCARD PYCARD CASP8 CASP8 CASP10 CASP10 ENSUAMP00000031902 ENSUAMP00000031902 TBC1D10A TBC1D10A PAWR PAWR ENSUAMP00000034017 ENSUAMP00000034017 RIPK2 RIPK2 ENSUAMP00000016800 ENSUAMP00000016800 ENSUAMP00000016311 ENSUAMP00000016311 CYCS CYCS FADD FADD ENSUAMP00000025917 ENSUAMP00000025917
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
ENSUAMP00000033283CIDE-N domain-containing protein. (208 aa)
BADBCL2 associated agonist of cell death. (168 aa)
LGMNLegumain. (433 aa)
ENSUAMP00000002418Asp-B-Hydro_N domain-containing protein. (277 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PYCARDPYD and CARD domain containing. (194 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (481 aa)
ENSUAMP00000031902CIDE-N domain-containing protein. (221 aa)
TBC1D10ATBC1 domain family member 10A. (560 aa)
PAWRPro-apoptotic WT1 regulator. (343 aa)
ENSUAMP00000034017Uncharacterized protein. (1081 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
ENSUAMP00000016800Uncharacterized protein. (294 aa)
ENSUAMP00000016311Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
ENSUAMP00000025917Uncharacterized protein. (93 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.