(54 nodes) Cellular response to alcohol network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (239 aa)
	LRP6	LDL receptor related protein 6. (1431 aa)
	OSBPL7	Oxysterol binding protein like 7. (941 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (986 aa)
	SFRP1	Secreted frizzled related protein 1. (337 aa)
	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (851 aa)
	ENSUAMP00000005292	DUF4502 domain-containing protein. (195 aa)
	PTGFR	Prostaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	PTCH1	Patched 1. (1453 aa)
	ENSUAMP00000008512	Biotin carboxylation domain-containing protein. (206 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1475 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (188 aa)
	ENSUAMP00000009775	C2 domain-containing protein. (151 aa)
	GLRA1	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (472 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	ENSUAMP00000011307	Uncharacterized protein. (1315 aa)
	GRAMD1C	GRAM domain containing 1C. (420 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2045 aa)
	GRAMD1A	GRAM domain containing 1A. (805 aa)
	SPHK2	Sphingosine kinase 2. (662 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (105 aa)
	ENSUAMP00000013669	Uncharacterized protein. (607 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (328 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (525 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	MLC1	Modulator of VRAC current 1. (373 aa)
	ENSUAMP00000017193	Uncharacterized protein. (91 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	ADAM15	ADAM metallopeptidase domain 15. (832 aa)
	ENSUAMP00000019286	DUF4502 domain-containing protein. (132 aa)
	ENSUAMP00000021070	Uncharacterized protein. (833 aa)
	FDX1	Ferredoxin 1. (124 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (798 aa)
	ENSUAMP00000021888	Uncharacterized protein. (100 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (726 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	LARP1	La ribonucleoprotein domain family member 1. (1102 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	ADCY5	Adenylate cyclase 5. (940 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ENSUAMP00000028494	Uncharacterized protein. (128 aa)
	ENSUAMP00000028498	Uncharacterized protein. (135 aa)
	ENSUAMP00000030084	VASt domain-containing protein. (439 aa)
	JUP	Junction plakoglobin. (744 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	NPAS4	Neuronal PAS domain protein 4. (800 aa)
	ENSUAMP00000035681	Protein kinase domain-containing protein. (217 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	ENSUAMP00000036260	Uncharacterized protein. (1033 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	ENSUAMP00000008512	ENSUAMP00000013160	ENSUAMP00000008512	Acetyl-CoA carboxylase beta.	Biotin carboxylation domain-containing protein.	0.923
ACACB	ENSUAMP00000011307	ENSUAMP00000013160	ENSUAMP00000011307	Acetyl-CoA carboxylase beta.	Uncharacterized protein.	0.797
ACACB	ENSUAMP00000036260	ENSUAMP00000013160	ENSUAMP00000036260	Acetyl-CoA carboxylase beta.	Uncharacterized protein.	0.795
ACACB	PRKAA1	ENSUAMP00000013160	ENSUAMP00000032879	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.886
ACACB	PRKAA2	ENSUAMP00000013160	ENSUAMP00000015599	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.913
ADCY1	ADCY3	ENSUAMP00000028025	ENSUAMP00000008710	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY1	ADCY5	ENSUAMP00000028025	ENSUAMP00000027941	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.539
ADCY1	ADCY6	ENSUAMP00000028025	ENSUAMP00000035722	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY7	ENSUAMP00000028025	ENSUAMP00000032396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.666
ADCY1	GNG2	ENSUAMP00000028025	ENSUAMP00000013493	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.916
ADCY3	ADCY1	ENSUAMP00000008710	ENSUAMP00000028025	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY3	ADCY5	ENSUAMP00000008710	ENSUAMP00000027941	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.567
ADCY3	ADCY6	ENSUAMP00000008710	ENSUAMP00000035722	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.947
ADCY3	ADCY7	ENSUAMP00000008710	ENSUAMP00000032396	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.555
ADCY3	GNG2	ENSUAMP00000008710	ENSUAMP00000013493	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.916
ADCY5	ADCY1	ENSUAMP00000027941	ENSUAMP00000028025	Adenylate cyclase 5.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.539
ADCY5	ADCY3	ENSUAMP00000027941	ENSUAMP00000008710	Adenylate cyclase 5.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.567
ADCY5	ADCY6	ENSUAMP00000027941	ENSUAMP00000035722	Adenylate cyclase 5.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.946
ADCY5	ADCY7	ENSUAMP00000027941	ENSUAMP00000032396	Adenylate cyclase 5.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.776
ADCY5	GNG2	ENSUAMP00000027941	ENSUAMP00000013493	Adenylate cyclase 5.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.922