STRINGSTRING
SYDE1 SYDE1 ENSUAMP00000000421 ENSUAMP00000000421 ARHGDIB ARHGDIB NODAL NODAL AGO2 AGO2 ENSUAMP00000015168 ENSUAMP00000015168 YTHDF3 YTHDF3 ENSUAMP00000016192 ENSUAMP00000016192 SMURF2 SMURF2 ACVR1B ACVR1B ACVR1C ACVR1C ENSUAMP00000037141 ENSUAMP00000037141 GJA1 GJA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYDE1Synapse defective Rho GTPase homolog 1. (735 aa)
ENSUAMP00000000421NTR domain-containing protein. (132 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (200 aa)
NODALNodal growth differentiation factor. (348 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (911 aa)
ENSUAMP00000015168Uncharacterized protein. (119 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
SMURF2E3 ubiquitin-protein ligase. (736 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
ENSUAMP00000037141Uncharacterized protein. (54 aa)
GJA1Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (382 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.