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| | AMT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa) |
| | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (306 aa) |
| | MTAP | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (255 aa) |
| | ENSUAMP00000000911 | Uncharacterized protein. (111 aa) |
| | AASDHPPT | Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa) |
| | ALDH8A1 | Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa) |
| | ENSUAMP00000001521 | Lipoyl-binding domain-containing protein. (129 aa) |
| | IVD | Isovaleryl-CoA dehydrogenase. (426 aa) |
| | LGSN | Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (509 aa) |
| | IL4I1 | Interleukin 4 induced 1. (572 aa) |
| | PSPH | Phosphoserine phosphatase. (225 aa) |
| | ENSUAMP00000003272 | SHMT domain-containing protein. (59 aa) |
| | HMGCLL1 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (345 aa) |
| | DCT | Dopachrome tautomerase. (400 aa) |
| | GLDC | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (991 aa) |
| | ATF4 | Activating transcription factor 4. (351 aa) |
| | SEPHS2 | Selenophosphate synthetase 2. (347 aa) |
| | ENSUAMP00000005051 | Uncharacterized protein. (58 aa) |
| | ENSUAMP00000005308 | DAO domain-containing protein. (175 aa) |
| | ENSUAMP00000005515 | Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (445 aa) |
| | GAD1 | Glutamate decarboxylase 1. (594 aa) |
| | PFAS | Phosphoribosylformylglycinamidine synthase. (1338 aa) |
| | HGD | Homogentisate 1,2-dioxygenase. (445 aa) |
| | ALDH6A1 | Aldehyde dehydrogenase 6 family member A1. (534 aa) |
| | UROC1 | Urocanate hydratase 1. (706 aa) |
| | OAT | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (399 aa) |
| | NAGS | N-acetylglutamate synthase. (523 aa) |
| | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase. (264 aa) |
| | ENSUAMP00000007782 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (156 aa) |
| | ENSUAMP00000008067 | BAAT_C domain-containing protein. (197 aa) |
| | GPT | Glutamic--pyruvic transaminase. (622 aa) |
| | CAD | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2218 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1064 aa) |
| | ENSUAMP00000008685 | DAO domain-containing protein. (116 aa) |
| | ACAT1 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa) |
| | ACADSB | Acyl-CoA dehydrogenase short/branched chain. (439 aa) |
| | CTPS2 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (594 aa) |
| | APIP | APAF1 interacting protein. (199 aa) |
| | TTC36 | Tetratricopeptide repeat domain 36. (189 aa) |
| | HAL | Histidine ammonia-lyase; Belongs to the PAL/histidase family. (663 aa) |
| | AMDHD1 | Amidohydrolase domain containing 1. (426 aa) |
| | RIMKLA | Ribosomal modification protein rimK like family member A. (391 aa) |
| | CTH | Cystathionine gamma-lyase. (409 aa) |
| | ENSUAMP00000010295 | DUF1794 domain-containing protein. (165 aa) |
| | ENSUAMP00000010334 | Fe-ADH domain-containing protein. (433 aa) |
| | HPD | 4-hydroxyphenylpyruvate dioxygenase. (435 aa) |
| | MCCC1 | Methylcrotonoyl-CoA carboxylase 1. (543 aa) |
| | HMGCL | 3-hydroxy-3-methylglutaryl-CoA lyase. (330 aa) |
| | THNSL1 | Threonine synthase like 1. (743 aa) |
| | ENSUAMP00000011289 | Uncharacterized protein. (495 aa) |
| | GOT2 | Aspartate aminotransferase. (393 aa) |
| | SEPHS1 | Selenophosphate synthetase 1. (392 aa) |
| | PSAT1 | Phosphoserine aminotransferase. (334 aa) |
| | ARG2 | Arginase. (354 aa) |
| | ENSUAMP00000012486 | Uncharacterized protein. (314 aa) |
| | MPST | Sulfurtransferase. (320 aa) |
| | TST | Sulfurtransferase. (297 aa) |
| | ENSUAMP00000012538 | 2-oxoacid_dh domain-containing protein. (170 aa) |
| | ENSUAMP00000012541 | Uncharacterized protein. (98 aa) |
| | ENSUAMP00000012599 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (573 aa) |
| | GCDH | Glutaryl-CoA dehydrogenase. (436 aa) |
| | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (723 aa) |
| | HOGA1 | 4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa) |
| | C10orf62 | Chromosome 10 open reading frame 62. (229 aa) |
| | BCAT2 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (463 aa) |
| | ENSUAMP00000013191 | CN hydrolase domain-containing protein. (91 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa) |
| | ENSUAMP00000013400 | Uncharacterized protein. (569 aa) |
| | ENSUAMP00000013409 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (578 aa) |
| | ALDH5A1 | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (546 aa) |
| | ENSUAMP00000013982 | Uncharacterized protein. (305 aa) |
| | IDO1 | Indoleamine 2,3-dioxygenase 1. (386 aa) |
| | ASNS | Asparagine synthetase [glutamine-hydrolyzing]. (561 aa) |
| | ENOPH1 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (261 aa) |
| | ENSUAMP00000014177 | Glutamine amidotransferase type-2 domain-containing protein. (644 aa) |
| | NOXRED1 | NADP dependent oxidoreductase domain containing 1. (329 aa) |
| | TMED8 | Transmembrane p24 trafficking protein family member 8. (332 aa) |
| | GSTZ1 | Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (213 aa) |
| | DDAH2 | Dimethylarginine dimethylaminohydrolase 2. (285 aa) |
| | ENSUAMP00000015562 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (471 aa) |
| | SCLY | Selenocysteine lyase. (445 aa) |
| | RIMKLB | Ribosomal modification protein rimK like family member B. (386 aa) |
| | MAT1A | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa) |
| | PYCR3 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (276 aa) |
| | ODC1 | Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (463 aa) |
| | ENSUAMP00000017059 | 2-oxoacid_dh domain-containing protein. (248 aa) |
| | DGLUCY | D-glutamate cyclase. (621 aa) |
| | PIPOX | Pipecolic acid and sarcosine oxidase. (386 aa) |
| | AZIN2 | Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (460 aa) |
| | MRI1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (384 aa) |
| | GMPS | Guanine monophosphate synthase. (693 aa) |
| | SLC39A8 | Solute carrier family 39 member 8. (283 aa) |
| | PLOD3 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (792 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (906 aa) |
| | GPT2 | Glutamic--pyruvic transaminase 2. (559 aa) |
| | ENSUAMP00000020684 | Uncharacterized protein. (592 aa) |
| | ENSUAMP00000020724 | Uncharacterized protein. (81 aa) |
| | PAH | Phenylalanine hydroxylase. (409 aa) |
| | PYCR1 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa) |
| | KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (422 aa) |
| | GFPT1 | Glutamine--fructose-6-phosphate transaminase 1. (595 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (474 aa) |
| | GNMT | Glycine N-methyltransferase. (295 aa) |
| | CDO1 | Cysteine dioxygenase. (200 aa) |
| | ADI1 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (179 aa) |
| | ENSUAMP00000023340 | DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa) |
| | MTR | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1178 aa) |
| | ENSUAMP00000023441 | DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa) |
| | SARDH | Sarcosine dehydrogenase. (601 aa) |
| | AGXT | Serine--pyruvate aminotransferase. (414 aa) |
| | MTHFR | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (654 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa) |
| | DDAH1 | Dimethylarginine dimethylaminohydrolase 1. (285 aa) |
| | SIRT4 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (312 aa) |
| | THNSL2 | Threonine synthase like 2. (435 aa) |
| | ENSUAMP00000025037 | Uncharacterized protein. (325 aa) |
| | FTCD | Formimidoyltransferase cyclodeaminase. (541 aa) |
| | DPEP1 | Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (410 aa) |
| | MECP2 | Methyl-CpG binding protein 2. (440 aa) |
| | GCAT | Glycine C-acetyltransferase. (419 aa) |
| | THAP8 | THAP domain containing 8. (223 aa) |
| | PRODH2 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (472 aa) |
| | MMUT | Methylmalonyl-CoA mutase. (750 aa) |
| | PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (728 aa) |
| | SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa) |
| | ENSUAMP00000027384 | Beta_elim_lyase domain-containing protein. (401 aa) |
| | MTHFD1 | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (992 aa) |
| | ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa) |
| | GLS2 | Glutaminase 2. (602 aa) |
| | TDO2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa) |
| | HIBADH | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (336 aa) |
| | AGXT2 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (513 aa) |
| | ENSUAMP00000029554 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (159 aa) |
| | ARG1 | Arginase. (322 aa) |
| | FPGS | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (579 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (636 aa) |
| | GOT1L1 | Glutamic-oxaloacetic transaminase 1 like 1. (406 aa) |
| | OTC | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa) |
| | ACAD8 | Acyl-CoA dehydrogenase family member 8. (415 aa) |
| | GOT1 | Aspartate aminotransferase. (413 aa) |
| | ASPG | Asparaginase. (655 aa) |
| | BHMT2 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (363 aa) |
| | BHMT | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (407 aa) |
| | QDPR | Quinoid dihydropteridine reductase. (242 aa) |
| | PADI3 | Peptidyl arginine deiminase 3. (643 aa) |
| | FAH | Fumarylacetoacetase. (419 aa) |
| | AZIN1 | Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (448 aa) |
| | ENSUAMP00000032679 | CoA carboxyltransferase N-terminal domain-containing protein. (212 aa) |
| | PHGDH | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa) |
| | GLUL | Glutamine synthetase. (484 aa) |
| | CPS1 | Carbamoyl-phosphate synthase 1. (994 aa) |
| | ENSUAMP00000032873 | CN hydrolase domain-containing protein. (283 aa) |
| | SRR | Serine racemase. (339 aa) |
| | ENSUAMP00000033021 | Uncharacterized protein. (295 aa) |
| | GLYAT | Uncharacterized protein. (295 aa) |
| | ENSUAMP00000033138 | Uncharacterized protein. (153 aa) |
| | ENSUAMP00000034153 | Epimerase domain-containing protein. (268 aa) |
| | ENSUAMP00000034431 | ANK_REP_REGION domain-containing protein. (93 aa) |
| | ENSUAMP00000034433 | Uncharacterized protein. (103 aa) |
| | ENSUAMP00000034435 | EF-hand_14 domain-containing protein. (259 aa) |
| | KYAT3 | Kynurenine aminotransferase 3. (455 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (576 aa) |
| | ENSUAMP00000034957 | Uncharacterized protein. (149 aa) |
| | TAT | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa) |
| | ASRGL1 | Asparaginase and isoaspartyl peptidase 1. (305 aa) |
| | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa) |
| | GCLM | Glutamate-cysteine ligase modifier subunit. (278 aa) |
| | ILVBL | IlvB acetolactate synthase like; Belongs to the TPP enzyme family. (632 aa) |
| | IYD | Iodotyrosine deiodinase. (289 aa) |
| | ENSUAMP00000037302 | FTCD_N domain-containing protein. (197 aa) |
| | SDS | Serine dehydratase. (328 aa) |
| | ENSUAMP00000037561 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (374 aa) |
| | SDSL | Serine dehydratase like. (329 aa) |
| | ENSUAMP00000000384 | NAD_binding_6 domain-containing protein. (147 aa) |
