14 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZC3H12A	Zinc finger CCCH-type containing 12A. (598 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
	ENSUAMP00000013482	Uncharacterized protein. (91 aa)
	ZC3H10	Zinc finger CCCH-type containing 10. (459 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (317 aa)
	BCDIN3D	BCDIN3 domain containing RNA methyltransferase. (292 aa)
	ESR1	Estrogen receptor 1. (490 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	NCOR2	Nuclear receptor corepressor 2. (2465 aa)
	LIN28B	Lin-28 homolog B. (254 aa)
	ENSUAMP00000025261	GPS2_interact domain-containing protein. (204 aa)
	NCOR1	Nuclear receptor corepressor 1. (2267 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCDIN3D	ZC3H10	ENSUAMP00000006402	ENSUAMP00000013051	BCDIN3 domain containing RNA methyltransferase.	Zinc finger CCCH-type containing 10.	0.436
ENSUAMP00000025261	ESR1	ENSUAMP00000025261	ENSUAMP00000006270	GPS2_interact domain-containing protein.	Estrogen receptor 1.	0.954
ENSUAMP00000025261	NCOR2	ENSUAMP00000025261	ENSUAMP00000030789	GPS2_interact domain-containing protein.	Nuclear receptor corepressor 2.	0.905
ESR1	ENSUAMP00000025261	ENSUAMP00000006270	ENSUAMP00000025261	Estrogen receptor 1.	GPS2_interact domain-containing protein.	0.954
ESR1	NCOR1	ENSUAMP00000006270	ENSUAMP00000025256	Estrogen receptor 1.	Nuclear receptor corepressor 1.	0.965
ESR1	NCOR2	ENSUAMP00000006270	ENSUAMP00000030789	Estrogen receptor 1.	Nuclear receptor corepressor 2.	0.862
ESR1	STAT3	ENSUAMP00000006270	ENSUAMP00000008772	Estrogen receptor 1.	Signal transducer and activator of transcription.	0.737
ESR1	TNF	ENSUAMP00000006270	ENSUAMP00000015695	Estrogen receptor 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.546
ESR1	TP53	ENSUAMP00000006270	ENSUAMP00000000913	Estrogen receptor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.861
NCOR1	ESR1	ENSUAMP00000025256	ENSUAMP00000006270	Nuclear receptor corepressor 1.	Estrogen receptor 1.	0.965
NCOR1	NCOR2	ENSUAMP00000025256	ENSUAMP00000030789	Nuclear receptor corepressor 1.	Nuclear receptor corepressor 2.	0.905
NCOR2	ENSUAMP00000025261	ENSUAMP00000030789	ENSUAMP00000025261	Nuclear receptor corepressor 2.	GPS2_interact domain-containing protein.	0.905
NCOR2	ESR1	ENSUAMP00000030789	ENSUAMP00000006270	Nuclear receptor corepressor 2.	Estrogen receptor 1.	0.862
NCOR2	NCOR1	ENSUAMP00000030789	ENSUAMP00000025256	Nuclear receptor corepressor 2.	Nuclear receptor corepressor 1.	0.905
STAT3	ESR1	ENSUAMP00000008772	ENSUAMP00000006270	Signal transducer and activator of transcription.	Estrogen receptor 1.	0.737
STAT3	TNF	ENSUAMP00000008772	ENSUAMP00000015695	Signal transducer and activator of transcription.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.729
STAT3	TP53	ENSUAMP00000008772	ENSUAMP00000000913	Signal transducer and activator of transcription.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.846
TNF	ESR1	ENSUAMP00000015695	ENSUAMP00000006270	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Estrogen receptor 1.	0.546
TNF	STAT3	ENSUAMP00000015695	ENSUAMP00000008772	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Signal transducer and activator of transcription.	0.729
TNF	TP53	ENSUAMP00000015695	ENSUAMP00000000913	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.633