STRINGSTRING
CAV3 CAV3 MSX1 MSX1 APCDD1 APCDD1 HOXC11 HOXC11 NOG NOG FZD2 FZD2 GREM1 GREM1 WNT11 WNT11 ENSUAMP00000002679 ENSUAMP00000002679 PAX9 PAX9 SFRP1 SFRP1 ENSUAMP00000005950 ENSUAMP00000005950 MKS1 MKS1 DVL3 DVL3 ENSUAMP00000007637 ENSUAMP00000007637 WNT2B WNT2B FGF10 FGF10 TACSTD2 TACSTD2 SEC24B SEC24B WNT2 WNT2 ABL1 ABL1 RYK RYK PLEKHA4 PLEKHA4 AJAP1 AJAP1 STOX1 STOX1 DAB2 DAB2 LGR4 LGR4 FGF7 FGF7 TNF TNF SOX8 SOX8 DVL1 DVL1 ANKRD6 ANKRD6 DMRT3 DMRT3 BTBD7 BTBD7 HOXA11 HOXA11 WNT10A WNT10A DVL2 DVL2 ENSUAMP00000018707 ENSUAMP00000018707 CELSR1 CELSR1 ENSUAMP00000019143 ENSUAMP00000019143 PTK7 PTK7 BMP2 BMP2 GPC3 GPC3 SP6 SP6 GDNF GDNF SIX4 SIX4 FZD3 FZD3 CITED2 CITED2 CTHRC1 CTHRC1 NGFR NGFR ENSUAMP00000023691 ENSUAMP00000023691 SPRY1 SPRY1 PAX8 PAX8 TNFRSF11B TNFRSF11B SOX9 SOX9 SIX2 SIX2 SMO SMO SULF1 SULF1 VANGL2 VANGL2 GRHL3 GRHL3 HOXB7 HOXB7 JHY JHY GATA3 GATA3 BMP4 BMP4 CSF1 CSF1 ENSUAMP00000029322 ENSUAMP00000029322 DACT1 DACT1 FGF1 FGF1 NKD1 NKD1 AHI1 AHI1 FRS2 FRS2 ENSUAMP00000035446 ENSUAMP00000035446 PHB2 PHB2 WNT9B WNT9B BMPR1A BMPR1A LHX1 LHX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MSX1Msh homeobox 1. (303 aa)
APCDD1APC down-regulated 1. (515 aa)
HOXC11Homeobox C11. (304 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENSUAMP00000002679Uncharacterized protein. (108 aa)
PAX9Paired box 9. (342 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
ENSUAMP00000005950SERPIN domain-containing protein; Belongs to the serpin family. (366 aa)
MKS1MKS transition zone complex subunit 1. (689 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
ENSUAMP00000007637Uncharacterized protein. (172 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
TACSTD2Tumor associated calcium signal transducer 2. (323 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (927 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ABL1Tyrosine-protein kinase. (1138 aa)
RYKReceptor like tyrosine kinase. (599 aa)
PLEKHA4Pleckstrin homology domain containing A4. (774 aa)
AJAP1Adherens junctions associated protein 1. (414 aa)
STOX1Storkhead box 1. (1069 aa)
DAB2DAB adaptor protein 2. (763 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (971 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
SOX8SRY-box transcription factor 8. (449 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
ANKRD6Ankyrin repeat domain 6. (673 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (476 aa)
BTBD7BTB domain containing 7. (1114 aa)
HOXA11Homeobox A11. (313 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
ENSUAMP00000018707SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2650 aa)
ENSUAMP00000019143Uncharacterized protein. (303 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
SP6Sp6 transcription factor. (376 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
SIX4SIX homeobox 4. (783 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
CTHRC1Collagen triple helix repeat containing 1. (277 aa)
NGFRNerve growth factor receptor. (388 aa)
ENSUAMP00000023691Uncharacterized protein. (268 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
PAX8Paired box 8. (458 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
SOX9SRY-box transcription factor 9. (484 aa)
SIX2SIX homeobox 2. (296 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (940 aa)
VANGL2Vang-like protein. (492 aa)
GRHL3Grainyhead like transcription factor 3. (614 aa)
HOXB7Homeobox B7. (217 aa)
JHYJunctional cadherin complex regulator. (774 aa)
GATA3GATA binding protein 3. (444 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CSF1Colony stimulating factor 1. (518 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (827 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (447 aa)
AHI1Abelson helper integration site 1. (1054 aa)
FRS2Fibroblast growth factor receptor substrate 2. (507 aa)
ENSUAMP00000035446Uncharacterized protein. (259 aa)
PHB2Prohibitin. (297 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LHX1LIM homeobox 1. (406 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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