33 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	GJA1	Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (382 aa)
	ELL3	Elongation factor for RNA polymerase II 3. (414 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	ENSUAMP00000007194	annotation not available (220 aa)
	ENSUAMP00000005136	Uncharacterized protein. (125 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ENSUAMP00000003662	MYND-type domain-containing protein. (344 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	FERMT2	Fermitin family member 2. (567 aa)
	HOXA3	Homeobox A3. (419 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (195 aa)
	KAT7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (592 aa)
	ENSUAMP00000025354	HMG box domain-containing protein. (302 aa)
	ENSUAMP00000025477	Uncharacterized protein. (185 aa)
	ENSUAMP00000025721	Uncharacterized protein. (113 aa)
	ATXN1L	Ataxin 1 like. (688 aa)
	SOX9	SRY-box transcription factor 9. (484 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1169 aa)
	OSR2	Odd-skipped related transciption factor 2. (312 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	ENSUAMP00000010127	Kindlin_2_N domain-containing protein. (70 aa)
	ENSUAMP00000029322	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
	HMX2	H6 family homeobox 2. (273 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (370 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000005136	ENSUAMP00000029322	ENSUAMP00000005136	ENSUAMP00000029322	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.439
ENSUAMP00000005136	KITLG	ENSUAMP00000005136	ENSUAMP00000030036	Uncharacterized protein.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.752
ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000025477	TP63	ENSUAMP00000025477	ENSUAMP00000007724	Uncharacterized protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.673
ENSUAMP00000029322	ENSUAMP00000005136	ENSUAMP00000029322	ENSUAMP00000005136	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.439
ENSUAMP00000029322	FGF10	ENSUAMP00000029322	ENSUAMP00000008288	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.515
ENSUAMP00000029322	GJA1	ENSUAMP00000029322	ENSUAMP00000035327	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...]	0.406
ENSUAMP00000029322	KDR	ENSUAMP00000029322	ENSUAMP00000023136	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.968
ENSUAMP00000029322	KITLG	ENSUAMP00000029322	ENSUAMP00000030036	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.573
ENSUAMP00000029322	SOX9	ENSUAMP00000029322	ENSUAMP00000026554	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.617
ENSUAMP00000029322	VEGFC	ENSUAMP00000029322	ENSUAMP00000014341	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.538
ENSUAMP00000029322	WNT1	ENSUAMP00000029322	ENSUAMP00000035647	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.439
FGF10	ENSUAMP00000029322	ENSUAMP00000008288	ENSUAMP00000029322	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.515
FGF10	FGF4	ENSUAMP00000008288	ENSUAMP00000032522	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.560
FGF10	KDR	ENSUAMP00000008288	ENSUAMP00000023136	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.943
FGF10	KITLG	ENSUAMP00000008288	ENSUAMP00000030036	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.439
FGF10	SOX9	ENSUAMP00000008288	ENSUAMP00000026554	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.547
FGF10	VEGFC	ENSUAMP00000008288	ENSUAMP00000014341	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.437
FGF4	FGF10	ENSUAMP00000032522	ENSUAMP00000008288	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.560