40 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	TERF2	Telomeric repeat binding factor 2. (521 aa)
	NUAK1	NUAK family kinase 1. (671 aa)
	ZNF277	Zinc finger protein 277. (409 aa)
	RSL1D1	Ribosomal L1 domain containing 1. (491 aa)
	CGAS	Cyclic GMP-AMP synthase. (406 aa)
	PAWR	Pro-apoptotic WT1 regulator. (343 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	ENSUAMP00000008701	Protein kinase domain-containing protein. (108 aa)
	BCL2L12	BCL2 like 12. (323 aa)
	ABL1	Tyrosine-protein kinase. (1138 aa)
	FBXO5	F-box protein 5. (448 aa)
	ENSUAMP00000012228	Uncharacterized protein. (61 aa)
	ARG2	Arginase. (354 aa)
	YPEL4	Protein yippee-like; Belongs to the yippee family. (127 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	VASH1	Vasohibin 1. (289 aa)
	NEK4	NIMA related kinase 4. (769 aa)
	ENSUAMP00000019533	CSD domain-containing protein. (311 aa)
	ENSUAMP00000020296	Uncharacterized protein. (87 aa)
	RBL1	RB transcriptional corepressor like 1. (1068 aa)
	ING2	Inhibitor of growth protein. (280 aa)
	SIRT1	Sirtuin 1. (618 aa)
	FZR1	Fizzy and cell division cycle 20 related 1. (493 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (694 aa)
	ENSUAMP00000023803	CSP domain-containing protein. (311 aa)
	SIRT6	Sirtuin 6. (338 aa)
	ENSUAMP00000025480	Uncharacterized protein. (157 aa)
	SLC30A10	Solute carrier family 30 member 10. (437 aa)
	YPEL1	Yippee like 1. (187 aa)
	YPEL2	Protein yippee-like; Belongs to the yippee family. (119 aa)
	ENSUAMP00000031510	Yippee domain-containing protein. (302 aa)
	ENSUAMP00000032581	GST C-terminal domain-containing protein. (174 aa)
	ENSUAMP00000032923	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
	ENSUAMP00000033940	GST C-terminal domain-containing protein. (170 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ENSUAMP00000020296	ENSUAMP00000009706	ENSUAMP00000020296	Tyrosine-protein kinase.	Uncharacterized protein.	0.642
ABL1	RBL1	ENSUAMP00000009706	ENSUAMP00000020637	Tyrosine-protein kinase.	RB transcriptional corepressor like 1.	0.445
ABL1	TP53	ENSUAMP00000009706	ENSUAMP00000000913	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.515
B2M	CDK6	ENSUAMP00000023655	ENSUAMP00000008521	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.532
B2M	TP53	ENSUAMP00000023655	ENSUAMP00000000913	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.480
BCL6	SIRT1	ENSUAMP00000014447	ENSUAMP00000021491	BCL6 transcription repressor.	Sirtuin 1.	0.499
BCL6	TP53	ENSUAMP00000014447	ENSUAMP00000000913	BCL6 transcription repressor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.598
CDK6	B2M	ENSUAMP00000008521	ENSUAMP00000023655	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.532
CDK6	ENSUAMP00000032923	ENSUAMP00000008521	ENSUAMP00000032923	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.584
CDK6	FZR1	ENSUAMP00000008521	ENSUAMP00000021899	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Fizzy and cell division cycle 20 related 1.	0.810
CDK6	RBL1	ENSUAMP00000008521	ENSUAMP00000020637	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	RB transcriptional corepressor like 1.	0.963
CDK6	SIRT1	ENSUAMP00000008521	ENSUAMP00000021491	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Sirtuin 1.	0.475
CDK6	TP53	ENSUAMP00000008521	ENSUAMP00000000913	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.782
CGAS	SIRT6	ENSUAMP00000006934	ENSUAMP00000024621	Cyclic GMP-AMP synthase.	Sirtuin 6.	0.536
ENSUAMP00000019533	TP53	ENSUAMP00000019533	ENSUAMP00000000913	CSD domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.493
ENSUAMP00000020296	ABL1	ENSUAMP00000020296	ENSUAMP00000009706	Uncharacterized protein.	Tyrosine-protein kinase.	0.642
ENSUAMP00000023803	TP53	ENSUAMP00000023803	ENSUAMP00000000913	CSP domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.493
ENSUAMP00000025480	TP53	ENSUAMP00000025480	ENSUAMP00000000913	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.493
ENSUAMP00000032923	CDK6	ENSUAMP00000032923	ENSUAMP00000008521	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.584
ENSUAMP00000032923	FZR1	ENSUAMP00000032923	ENSUAMP00000021899	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	Fizzy and cell division cycle 20 related 1.	0.501