(117 nodes) Positive regulation of cysteine-type endopeptidase activity network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MTCH1	Mitochondrial carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (874 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	NDUFA13	NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
	YJEFN3	YjeF N-terminal domain-containing protein. (250 aa)
	ENSUAMP00000000737	Uncharacterized protein. (81 aa)
	ENSUAMP00000000744	Uncharacterized protein. (157 aa)
	ENSUAMP00000002418	Asp-B-Hydro_N domain-containing protein. (277 aa)
	ENSUAMP00000002924	Uncharacterized protein. (335 aa)
	GSN	Gelsolin. (742 aa)
	ENSUAMP00000003468	Uncharacterized protein. (146 aa)
	ENSUAMP00000003662	MYND-type domain-containing protein. (344 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (136 aa)
	ENSUAMP00000003947	Protein S100; Belongs to the S-100 family. (130 aa)
	ENSUAMP00000004351	CARD domain-containing protein. (165 aa)
	ENSUAMP00000004918	Homeobox domain-containing protein. (230 aa)
	ENSUAMP00000006064	Uncharacterized protein. (80 aa)
	ENSUAMP00000006350	Uncharacterized protein. (85 aa)
	TFAP4	Transcription factor AP-4. (339 aa)
	ENSUAMP00000006607	Uncharacterized protein. (215 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1077 aa)
	TTBK1	Tau tubulin kinase 1. (1288 aa)
	ENSUAMP00000007194	annotation not available (220 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1212 aa)
	PAWR	Pro-apoptotic WT1 regulator. (343 aa)
	TBC1D10A	TBC1 domain family member 10A. (560 aa)
	ENSUAMP00000007992	Uncharacterized protein. (219 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (481 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (395 aa)
	PDCD5	Programmed cell death 5. (125 aa)
	ENSUAMP00000008796	KH type-2 domain-containing protein. (92 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	PYCARD	PYD and CARD domain containing. (194 aa)
	ENSUAMP00000010575	Uncharacterized protein. (237 aa)
	CLEC7A	C-type lectin domain containing 7A. (237 aa)
	ENSUAMP00000011223	Uncharacterized protein. (224 aa)
	ENSUAMP00000011673	EF-hand domain-containing protein; Belongs to the S-100 family. (87 aa)
	CARD9	Caspase recruitment domain family member 9. (566 aa)
	UACA	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1399 aa)
	BAX	BCL2 associated X, apoptosis regulator. (205 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (196 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (594 aa)
	PPM1F	Protein phosphatase, Mg2+/Mn2+ dependent 1F. (441 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
	ENSUAMP00000014717	Uncharacterized protein. (131 aa)
	HIP1	Huntingtin interacting protein 1. (681 aa)
	CASP8AP2	Caspase 8 associated protein 2. (1994 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
	ENSUAMP00000016276	Uncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
	ENSUAMP00000016311	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
	ENSUAMP00000016646	Uncharacterized protein. (167 aa)
	ENSUAMP00000016800	Uncharacterized protein. (294 aa)
	ENSUAMP00000017004	LRRcap domain-containing protein. (420 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
	ATP2A3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (982 aa)
	ENSUAMP00000017736	Cation_ATPase_N domain-containing protein. (54 aa)
	ENSUAMP00000018082	Uncharacterized protein. (249 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	ENSUAMP00000019295	Uncharacterized protein. (386 aa)
	RACK1	Receptor for activated C kinase 1. (374 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	FIS1	Fission, mitochondrial 1. (166 aa)
	BCAP31	B cell receptor associated protein 31. (257 aa)
	ENSUAMP00000021352	Uncharacterized protein. (141 aa)
	SIRT1	Sirtuin 1. (618 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (467 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
	ENSUAMP00000022738	Uncharacterized protein. (126 aa)
	CCN1	Cellular communication network factor 1. (382 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
	LAPTM5	Lysosomal protein transmembrane 5. (263 aa)
	NGFR	Nerve growth factor receptor. (388 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (289 aa)
	ENSUAMP00000024045	Uncharacterized protein. (363 aa)
	ENSUAMP00000024047	GRAM domain-containing protein. (153 aa)
	ENSUAMP00000024458	Uncharacterized protein. (155 aa)
	BCL10	BCL10 immune signaling adaptor. (234 aa)
	ENSUAMP00000025110	Uncharacterized protein. (88 aa)
	NLRP1	NLR family pyrin domain containing 1. (1427 aa)
	ENSUAMP00000025828	Uncharacterized protein; Belongs to the peptidase C14A family. (317 aa)
	ENSUAMP00000025829	CARD domain-containing protein. (86 aa)
	ENSUAMP00000025917	Uncharacterized protein. (93 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (372 aa)
	EGLN3	Egl-9 family hypoxia inducible factor 3. (239 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S type. (666 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	ENSUAMP00000027937	Uncharacterized protein. (426 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	F3	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (288 aa)
	PIDD1	P53-induced death domain protein 1. (911 aa)
	PDCD6	Programmed cell death 6. (189 aa)
	CYCS	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	TNFSF15	TNF superfamily member 15. (174 aa)
	NEK5	NIMA related kinase 5. (685 aa)
	BCL2L11	BCL2 like 11. (140 aa)
	ENSUAMP00000029915	Uncharacterized protein. (90 aa)
	PRR7	Proline rich 7, synaptic. (269 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	USP50	Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (366 aa)
	ENSUAMP00000031902	CIDE-N domain-containing protein. (221 aa)
	SYK	Spleen associated tyrosine kinase. (638 aa)
	PML	Promyelocytic leukemia. (877 aa)
	ENSUAMP00000033283	CIDE-N domain-containing protein. (208 aa)
	ENSUAMP00000033323	CARD domain-containing protein. (221 aa)
	ENSUAMP00000034017	Uncharacterized protein. (1081 aa)
	ENSUAMP00000035027	Uncharacterized protein. (146 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	ENSUAMP00000035281	ULP_PROTEASE domain-containing protein. (102 aa)
	FOXL2	Forkhead box L2. (270 aa)
	LGMN	Legumain. (433 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	ENSUAMP00000036338	Uncharacterized protein. (747 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1C	NODAL	ENSUAMP00000022640	ENSUAMP00000009938	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Nodal growth differentiation factor.	0.963
ACVR1C	SMAD3	ENSUAMP00000022640	ENSUAMP00000026563	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.964
AIFM1	BAK1	ENSUAMP00000013442	ENSUAMP00000000602	Apoptosis inducing factor mitochondria associated 1.	BCL2 antagonist/killer 1.	0.533
AIFM1	BAX	ENSUAMP00000013442	ENSUAMP00000013214	Apoptosis inducing factor mitochondria associated 1.	BCL2 associated X, apoptosis regulator.	0.884
BAD	BAK1	ENSUAMP00000019222	ENSUAMP00000000602	BCL2 associated agonist of cell death.	BCL2 antagonist/killer 1.	0.846
BAD	BAX	ENSUAMP00000019222	ENSUAMP00000013214	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.854
BAD	BCL2L11	ENSUAMP00000019222	ENSUAMP00000029698	BCL2 associated agonist of cell death.	BCL2 like 11.	0.914
BAD	BID	ENSUAMP00000019222	ENSUAMP00000013308	BCL2 associated agonist of cell death.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.742
BAD	BOK	ENSUAMP00000019222	ENSUAMP00000010294	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.821
BAD	CASP9	ENSUAMP00000019222	ENSUAMP00000022586	BCL2 associated agonist of cell death.	Caspase 9; Belongs to the peptidase C14A family.	0.547
BAD	ENSUAMP00000004351	ENSUAMP00000019222	ENSUAMP00000004351	BCL2 associated agonist of cell death.	CARD domain-containing protein.	0.457
BAD	ENSUAMP00000007992	ENSUAMP00000019222	ENSUAMP00000007992	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.428
BAD	ENSUAMP00000025828	ENSUAMP00000019222	ENSUAMP00000025828	BCL2 associated agonist of cell death.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.457
BAD	ENSUAMP00000025829	ENSUAMP00000019222	ENSUAMP00000025829	BCL2 associated agonist of cell death.	CARD domain-containing protein.	0.457
BAD	FADD	ENSUAMP00000019222	ENSUAMP00000027565	BCL2 associated agonist of cell death.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.537
BAK1	AIFM1	ENSUAMP00000000602	ENSUAMP00000013442	BCL2 antagonist/killer 1.	Apoptosis inducing factor mitochondria associated 1.	0.533
BAK1	BAD	ENSUAMP00000000602	ENSUAMP00000019222	BCL2 antagonist/killer 1.	BCL2 associated agonist of cell death.	0.846
BAK1	BAX	ENSUAMP00000000602	ENSUAMP00000013214	BCL2 antagonist/killer 1.	BCL2 associated X, apoptosis regulator.	0.975
BAK1	BCL2L11	ENSUAMP00000000602	ENSUAMP00000029698	BCL2 antagonist/killer 1.	BCL2 like 11.	0.972
BAK1	BID	ENSUAMP00000000602	ENSUAMP00000013308	BCL2 antagonist/killer 1.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.996