(16 nodes) Replisome network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLD1	DNA polymerase. (1109 aa)
	DONSON	Downstream neighbor of SON. (513 aa)
	ENSUAMP00000031944	Uncharacterized protein. (79 aa)
	ENSUAMP00000033824	CDT1 domain-containing protein. (780 aa)
	ENSUAMP00000001303	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (578 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	ENSUAMP00000006705	Uncharacterized protein. (266 aa)
	TENT5C	Terminal nucleotidyltransferase 5C. (391 aa)
	ENSUAMP00000011011	Uncharacterized protein. (465 aa)
	ENSUAMP00000013559	Uncharacterized protein. (126 aa)
	ENSUAMP00000028972	Uncharacterized protein. (262 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
	TENT5A	Terminal nucleotidyltransferase 5A. (487 aa)
	ENSUAMP00000019470	Uncharacterized protein. (87 aa)
	DARS2	Aspartyl-tRNA synthetase 2, mitochondrial. (654 aa)
	ENSUAMP00000028130	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC6	ENSUAMP00000001303	ENSUAMP00000019116	ENSUAMP00000001303	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.874
CDC6	ENSUAMP00000013559	ENSUAMP00000019116	ENSUAMP00000013559	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Uncharacterized protein.	0.840
CDC6	ENSUAMP00000028130	ENSUAMP00000019116	ENSUAMP00000028130	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.871
CDC6	ENSUAMP00000028972	ENSUAMP00000019116	ENSUAMP00000028972	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Uncharacterized protein.	0.643
CDC6	ENSUAMP00000031944	ENSUAMP00000019116	ENSUAMP00000031944	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Uncharacterized protein.	0.643
CDC6	ENSUAMP00000033824	ENSUAMP00000019116	ENSUAMP00000033824	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	CDT1 domain-containing protein.	0.999
CDC6	POLD1	ENSUAMP00000019116	ENSUAMP00000018861	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA polymerase.	0.767
DONSON	ENSUAMP00000001303	ENSUAMP00000019008	ENSUAMP00000001303	Downstream neighbor of SON.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.649
DONSON	ENSUAMP00000013559	ENSUAMP00000019008	ENSUAMP00000013559	Downstream neighbor of SON.	Uncharacterized protein.	0.693
DONSON	ENSUAMP00000028130	ENSUAMP00000019008	ENSUAMP00000028130	Downstream neighbor of SON.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.483
DONSON	ENSUAMP00000033824	ENSUAMP00000019008	ENSUAMP00000033824	Downstream neighbor of SON.	CDT1 domain-containing protein.	0.437
DONSON	POLD1	ENSUAMP00000019008	ENSUAMP00000018861	Downstream neighbor of SON.	DNA polymerase.	0.585
DONSON	POLD2	ENSUAMP00000019008	ENSUAMP00000005266	Downstream neighbor of SON.	DNA polymerase delta 2, accessory subunit.	0.796
ENSUAMP00000001303	CDC6	ENSUAMP00000001303	ENSUAMP00000019116	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.874
ENSUAMP00000001303	DONSON	ENSUAMP00000001303	ENSUAMP00000019008	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	Downstream neighbor of SON.	0.649
ENSUAMP00000001303	ENSUAMP00000006705	ENSUAMP00000001303	ENSUAMP00000006705	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	Uncharacterized protein.	0.656
ENSUAMP00000001303	ENSUAMP00000011011	ENSUAMP00000001303	ENSUAMP00000011011	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	Uncharacterized protein.	0.753
ENSUAMP00000001303	ENSUAMP00000013559	ENSUAMP00000001303	ENSUAMP00000013559	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	Uncharacterized protein.	0.998
ENSUAMP00000001303	ENSUAMP00000028130	ENSUAMP00000001303	ENSUAMP00000028130	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.998
ENSUAMP00000001303	ENSUAMP00000028972	ENSUAMP00000001303	ENSUAMP00000028972	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	Uncharacterized protein.	0.571