(5 nodes) Ripoptosome network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (395 aa)
	ENSUAMP00000007992	Uncharacterized protein. (219 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (550 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP8	ENSUAMP00000007992	ENSUAMP00000007996	ENSUAMP00000007992	Caspase 8; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.986
CASP8	FADD	ENSUAMP00000007996	ENSUAMP00000027565	Caspase 8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	PCSK1	ENSUAMP00000007996	ENSUAMP00000005388	Caspase 8; Belongs to the peptidase C14A family.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.603
CASP8	RIPK1	ENSUAMP00000007996	ENSUAMP00000019468	Caspase 8; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.998
ENSUAMP00000007992	CASP8	ENSUAMP00000007992	ENSUAMP00000007996	Uncharacterized protein.	Caspase 8; Belongs to the peptidase C14A family.	0.986
ENSUAMP00000007992	FADD	ENSUAMP00000007992	ENSUAMP00000027565	Uncharacterized protein.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.991
ENSUAMP00000007992	RIPK1	ENSUAMP00000007992	ENSUAMP00000019468	Uncharacterized protein.	Receptor interacting serine/threonine kinase 1.	0.797
FADD	CASP8	ENSUAMP00000027565	ENSUAMP00000007996	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 8; Belongs to the peptidase C14A family.	0.999
FADD	ENSUAMP00000007992	ENSUAMP00000027565	ENSUAMP00000007992	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Uncharacterized protein.	0.991
FADD	PCSK1	ENSUAMP00000027565	ENSUAMP00000005388	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.551
FADD	RIPK1	ENSUAMP00000027565	ENSUAMP00000019468	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.999
PCSK1	CASP8	ENSUAMP00000005388	ENSUAMP00000007996	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	Caspase 8; Belongs to the peptidase C14A family.	0.603
PCSK1	FADD	ENSUAMP00000005388	ENSUAMP00000027565	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.551
PCSK1	RIPK1	ENSUAMP00000005388	ENSUAMP00000019468	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	Receptor interacting serine/threonine kinase 1.	0.671
RIPK1	CASP8	ENSUAMP00000019468	ENSUAMP00000007996	Receptor interacting serine/threonine kinase 1.	Caspase 8; Belongs to the peptidase C14A family.	0.998
RIPK1	ENSUAMP00000007992	ENSUAMP00000019468	ENSUAMP00000007992	Receptor interacting serine/threonine kinase 1.	Uncharacterized protein.	0.797
RIPK1	FADD	ENSUAMP00000019468	ENSUAMP00000027565	Receptor interacting serine/threonine kinase 1.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
RIPK1	PCSK1	ENSUAMP00000019468	ENSUAMP00000005388	Receptor interacting serine/threonine kinase 1.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.671