STRINGSTRING
ACVR1C ACVR1C CHRNA5 CHRNA5 TPD52 TPD52 GP9 GP9 ENSUAMP00000024427 ENSUAMP00000024427 DLG3 DLG3 AADACL4 AADACL4 AADACL3 AADACL3 ENSUAMP00000025740 ENSUAMP00000025740 ENSUAMP00000025752 ENSUAMP00000025752 ENSUAMP00000025766 ENSUAMP00000025766 ENSUAMP00000025894 ENSUAMP00000025894 IL23R IL23R ENSUAMP00000026974 ENSUAMP00000026974 GRIN3A GRIN3A LRRTM4 LRRTM4 IL18RAP IL18RAP ITGB5 ITGB5 IL18R1 IL18R1 ERBB3 ERBB3 ENSUAMP00000012931 ENSUAMP00000012931 ENSUAMP00000012811 ENSUAMP00000012811 HTR3C HTR3C HTR3D HTR3D ENSUAMP00000012642 ENSUAMP00000012642 ENSUAMP00000012611 ENSUAMP00000012611 GABBR1 GABBR1 ENSUAMP00000012576 ENSUAMP00000012576 ENSUAMP00000012318 ENSUAMP00000012318 GRIK3 GRIK3 ITGA8 ITGA8 ERBB2 ERBB2 SHISA9 SHISA9 SDCBP SDCBP ENSUAMP00000010738 ENSUAMP00000010738 ENSUAMP00000010575 ENSUAMP00000010575 ITGAM ITGAM ABL1 ABL1 CHRNB3 CHRNB3 CHRNA6 CHRNA6 ENSUAMP00000009398 ENSUAMP00000009398 ITGAD ITGAD RAMP1 RAMP1 SSTR2 SSTR2 CD2 CD2 CD79B CD79B IL27RA IL27RA CD79A CD79A CSF2 CSF2 ENSUAMP00000008343 ENSUAMP00000008343 EMILIN1 EMILIN1 ENSUAMP00000007195 ENSUAMP00000007195 ACVR2B ACVR2B ITGA2B ITGA2B ENSUAMP00000006772 ENSUAMP00000006772 GRIN3B GRIN3B SEMA3E SEMA3E ENSUAMP00000006110 ENSUAMP00000006110 ENSUAMP00000005886 ENSUAMP00000005886 ENSUAMP00000005684 ENSUAMP00000005684 ENSUAMP00000005484 ENSUAMP00000005484 CHRNA2 CHRNA2 GPR156 GPR156 ENSUAMP00000004365 ENSUAMP00000004365 CD3E CD3E SCP2D1 SCP2D1 ACVR1 ACVR1 CD3D CD3D CD3G CD3G ITGB7 ITGB7 ENSUAMP00000003512 ENSUAMP00000003512 FGFBP1 FGFBP1 SSTR1 SSTR1 ITGA1 ITGA1 ENSUAMP00000002412 ENSUAMP00000002412 ENSUAMP00000002254 ENSUAMP00000002254 CCR9 CCR9 ITGB8 ITGB8 IL1RL2 IL1RL2 ENSUAMP00000001454 ENSUAMP00000001454 GRIA4 GRIA4 IL1R1 IL1R1 ENSUAMP00000000518 ENSUAMP00000000518 ENSUAMP00000013975 ENSUAMP00000013975 GRIA3 GRIA3 IRS2 IRS2 ENSUAMP00000014948 ENSUAMP00000014948 IGF1R IGF1R ENSUAMP00000037288 ENSUAMP00000037288 ENSUAMP00000037275 ENSUAMP00000037275 ENSUAMP00000037274 ENSUAMP00000037274 ENSUAMP00000037273 ENSUAMP00000037273 CYP4F8 CYP4F8 ENSUAMP00000037267 ENSUAMP00000037267 TFR2 TFR2 AASDH AASDH BMPR2 BMPR2 BMPR1A BMPR1A ENSUAMP00000036166 ENSUAMP00000036166 CHRNA10 CHRNA10 ABHD6 ABHD6 ITGA2 ITGA2 ENSUAMP00000035186 ENSUAMP00000035186 ENSUAMP00000035018 ENSUAMP00000035018 VWC2L VWC2L TRAF3 TRAF3 ITGA6 ITGA6 GRIN2B GRIN2B GRIK4 GRIK4 BMPR1B BMPR1B CHRNA4 CHRNA4 NPNT NPNT ENSUAMP00000032110 ENSUAMP00000032110 SYK SYK TSPAN32 TSPAN32 OSMR OSMR SSTR3 SSTR3 IL6 IL6 MCMDC2 MCMDC2 ITGAV ITGAV IL6ST IL6ST ENSUAMP00000029346 ENSUAMP00000029346 IL5RA IL5RA IRS1 IRS1 CD27 CD27 ITGB6 ITGB6 ENSUAMP00000028937 ENSUAMP00000028937 ITGAL ITGAL ITGA5 ITGA5 HJV HJV ENSUAMP00000028361 ENSUAMP00000028361 ITGA10 ITGA10 GRIN1 GRIN1 ENSUAMP00000027869 ENSUAMP00000027869 CALCRL CALCRL CNIH2 CNIH2 GRIK5 GRIK5 GP1BB GP1BB ACVR2A ACVR2A ENSUAMP00000000513 ENSUAMP00000000513 ENSUAMP00000015124 ENSUAMP00000015124 ENSUAMP00000015381 ENSUAMP00000015381 ENSUAMP00000015620 ENSUAMP00000015620 ENSUAMP00000015653 ENSUAMP00000015653 ENSUAMP00000015656 ENSUAMP00000015656 ENSUAMP00000015992 ENSUAMP00000015992 RAMP3 RAMP3 RAMP2 RAMP2 TGFBR1 TGFBR1 IL13RA1 IL13RA1 INSRR INSRR ADAM28 ADAM28 ACVRL1 ACVRL1 ACVR1B ACVR1B ITGAE ITGAE IL12RB1 IL12RB1 ITGA3 ITGA3 IL6R IL6R CHRNB2 CHRNB2 CHRNB1 CHRNB1 PMP22 PMP22 ITGA7 ITGA7 ENSUAMP00000019252 ENSUAMP00000019252 TLR6 TLR6 TLR1 TLR1 ANGPTL2 ANGPTL2 CHRNA9 CHRNA9 ITGA11 ITGA11 RASD2 RASD2 ENSUAMP00000020458 ENSUAMP00000020458 HTR3A HTR3A HTR3B HTR3B PRF1 PRF1 BMP2 BMP2 GRIN2A GRIN2A ENSUAMP00000021989 ENSUAMP00000021989 TLR2 TLR2 CACNG2 CACNG2 IL20RA IL20RA CNTFR CNTFR ENSUAMP00000022491 ENSUAMP00000022491 INSR INSR CD6 CD6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (453 aa)
TPD52Uncharacterized protein. (247 aa)
GP9Glycoprotein IX platelet. (177 aa)
ENSUAMP00000024427Recep_L_domain domain-containing protein. (297 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (830 aa)
AADACL4Arylacetamide deacetylase like 4. (404 aa)
AADACL3Arylacetamide deacetylase like 3. (350 aa)
ENSUAMP00000025740Uncharacterized protein. (466 aa)
ENSUAMP00000025752Uncharacterized protein. (191 aa)
ENSUAMP00000025766Uncharacterized protein. (229 aa)
ENSUAMP00000025894Integrin_alpha2 domain-containing protein. (435 aa)
IL23RInterleukin 23 receptor. (631 aa)
ENSUAMP00000026974Uncharacterized protein. (80 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1103 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (522 aa)
IL18RAPInterleukin 18 receptor accessory protein. (573 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (621 aa)
IL18R1Interleukin 18 receptor 1. (541 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1281 aa)
ENSUAMP00000012931Uncharacterized protein. (182 aa)
ENSUAMP00000012811Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (445 aa)
HTR3C5-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
HTR3D5-hydroxytryptamine receptor 3D; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
ENSUAMP00000012642Integrin_alpha2 domain-containing protein. (261 aa)
ENSUAMP00000012611Sushi domain-containing protein. (238 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (844 aa)
ENSUAMP00000012576Uncharacterized protein. (850 aa)
ENSUAMP00000012318Uncharacterized protein. (189 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (950 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (901 aa)
ERBB2Receptor protein-tyrosine kinase. (1261 aa)
SHISA9Shisa family member 9. (268 aa)
SDCBPSyndecan binding protein. (317 aa)
ENSUAMP00000010738Uncharacterized protein. (181 aa)
ENSUAMP00000010575Uncharacterized protein. (237 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1208 aa)
ABL1Tyrosine-protein kinase. (1138 aa)
CHRNB3Cholinergic receptor nicotinic beta 3 subunit. (445 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (354 aa)
ENSUAMP00000009398VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1150 aa)
ITGADIntegrin subunit alpha D; Belongs to the integrin alpha chain family. (1173 aa)
RAMP1Receptor activity modifying protein 1. (148 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CD2CD2 molecule. (344 aa)
CD79BCD79b molecule. (299 aa)
IL27RAInterleukin 27 receptor subunit alpha. (632 aa)
CD79ACD79a molecule. (231 aa)
CSF2Colony stimulating factor 2. (155 aa)
ENSUAMP00000008343Uncharacterized protein. (163 aa)
EMILIN1Elastin microfibril interfacer 1. (1020 aa)
ENSUAMP00000007195Ig-like domain-containing protein. (196 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1032 aa)
ENSUAMP00000006772Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1001 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
ENSUAMP00000006110Ig-like domain-containing protein. (196 aa)
ENSUAMP00000005886Ig-like domain-containing protein. (157 aa)
ENSUAMP00000005684Uncharacterized protein. (146 aa)
ENSUAMP00000005484Ig-like domain-containing protein. (156 aa)
CHRNA2Cholinergic receptor nicotinic alpha 2 subunit. (506 aa)
GPR156G protein-coupled receptor 156. (816 aa)
ENSUAMP00000004365Fibrillar collagen NC1 domain-containing protein. (111 aa)
CD3ECD3e molecule. (207 aa)
SCP2D1SCP2 sterol binding domain containing 1. (156 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CD3DCD3d molecule. (171 aa)
CD3GCD3g molecule. (164 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (847 aa)
ENSUAMP00000003512LRRCT domain-containing protein. (390 aa)
FGFBP1Fibroblast growth factor binding protein 1. (255 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1143 aa)
ENSUAMP00000002412Uncharacterized protein. (71 aa)
ENSUAMP00000002254Uncharacterized protein. (308 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (368 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
IL1RL2Interleukin 1 receptor like 2. (554 aa)
ENSUAMP00000001454Uncharacterized protein. (150 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (957 aa)
IL1R1Interleukin 1 receptor type 1. (584 aa)
ENSUAMP00000000518Uncharacterized protein. (334 aa)
ENSUAMP00000013975Uncharacterized protein; Belongs to the cytochrome P450 family. (181 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (601 aa)
IRS2Insulin receptor substrate 2. (1089 aa)
ENSUAMP00000014948Uncharacterized protein. (273 aa)
IGF1RTyrosine-protein kinase receptor. (1288 aa)
ENSUAMP00000037288Uncharacterized protein. (95 aa)
ENSUAMP00000037275Uncharacterized protein; Belongs to the cytochrome P450 family. (182 aa)
ENSUAMP00000037274Uncharacterized protein. (439 aa)
ENSUAMP00000037273Uncharacterized protein. (208 aa)
CYP4F8Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa)
ENSUAMP00000037267Uncharacterized protein. (83 aa)
TFR2Transferrin receptor 2. (592 aa)
AASDHAminoadipate-semialdehyde dehydrogenase. (1097 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSUAMP00000036166Uncharacterized protein. (570 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (447 aa)
ABHD6Abhydrolase domain containing 6. (337 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1121 aa)
ENSUAMP00000035186ANF_receptor domain-containing protein. (305 aa)
ENSUAMP00000035018Uncharacterized protein. (190 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (131 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1091 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (903 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (624 aa)
NPNTNephronectin. (462 aa)
ENSUAMP00000032110Uncharacterized protein. (154 aa)
SYKSpleen associated tyrosine kinase. (638 aa)
TSPAN32Tetraspanin 32. (257 aa)
OSMROncostatin M receptor. (968 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (414 aa)
IL6Interleukin 6. (212 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
ENSUAMP00000029346Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (703 aa)
IL5RAInterleukin 5 receptor subunit alpha. (417 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
CD27CD27 molecule. (231 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
ENSUAMP00000028937SCY domain-containing protein. (150 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1014 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1067 aa)
HJVHemojuvelin BMP co-receptor. (317 aa)
ENSUAMP00000028361Uncharacterized protein. (530 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1130 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (814 aa)
ENSUAMP00000027869PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (282 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (148 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (969 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (296 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
ENSUAMP00000000513G_PROTEIN_RECEP_F3_4 domain-containing protein. (287 aa)
ENSUAMP00000015124Fibrillar collagen NC1 domain-containing protein. (1153 aa)
ENSUAMP00000015381ANF_receptor domain-containing protein. (158 aa)
ENSUAMP00000015620Uncharacterized protein. (577 aa)
ENSUAMP00000015653Uncharacterized protein. (172 aa)
ENSUAMP00000015656Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (300 aa)
ENSUAMP00000015992G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (246 aa)
RAMP3Receptor activity modifying protein 3. (138 aa)
RAMP2Receptor activity modifying protein 2. (100 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (424 aa)
INSRRTyrosine-protein kinase receptor. (1318 aa)
ADAM28ADAM metallopeptidase domain 28. (755 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
ITGAEIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1054 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (700 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1051 aa)
IL6RInterleukin 6 receptor. (496 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (463 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (576 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
ENSUAMP00000019252Ig-like domain-containing protein. (196 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (778 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (802 aa)
ANGPTL2Angiopoietin like 2. (493 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (478 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1220 aa)
RASD2RASD family member 2. (352 aa)
ENSUAMP00000020458IGv domain-containing protein. (196 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (479 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (442 aa)
PRF1Perforin 1. (555 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1427 aa)
ENSUAMP00000021989Uncharacterized protein. (179 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (787 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
IL20RAInterleukin 20 receptor subunit alpha. (553 aa)
CNTFRCiliary neurotrophic factor receptor. (344 aa)
ENSUAMP00000022491Ig-like domain-containing protein. (323 aa)
INSRTyrosine-protein kinase receptor. (1072 aa)
CD6CD6 molecule. (673 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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