STRINGSTRING
ENSUAMP00000023031 ENSUAMP00000023031 ENSUAMP00000005324 ENSUAMP00000005324 PFAS PFAS ENSUAMP00000005938 ENSUAMP00000005938 ENSUAMP00000005950 ENSUAMP00000005950 NDUFB4 NDUFB4 FOXRED1 FOXRED1 ENSUAMP00000006504 ENSUAMP00000006504 ENSUAMP00000006524 ENSUAMP00000006524 ENSUAMP00000007578 ENSUAMP00000007578 ENSUAMP00000007782 ENSUAMP00000007782 ENSUAMP00000007787 ENSUAMP00000007787 AMT AMT BCKDHB BCKDHB RSU1 RSU1 CAT CAT NCF1 NCF1 ENSUAMP00000011085 ENSUAMP00000011085 ALDH7A1 ALDH7A1 ENSUAMP00000011673 ENSUAMP00000011673 ENSUAMP00000011699 ENSUAMP00000011699 ENSUAMP00000012006 ENSUAMP00000012006 NDUFV1 NDUFV1 DMAC2 DMAC2 ENSUAMP00000012476 ENSUAMP00000012476 NDUFA6 NDUFA6 ENSUAMP00000012538 ENSUAMP00000012538 ENSUAMP00000012541 ENSUAMP00000012541 ENSUAMP00000012629 ENSUAMP00000012629 GLOD5 GLOD5 FDXR FDXR DHDH DHDH ENSUAMP00000014276 ENSUAMP00000014276 NDUFC1 NDUFC1 ENSUAMP00000014576 ENSUAMP00000014576 ENSUAMP00000014708 ENSUAMP00000014708 ENSUAMP00000015562 ENSUAMP00000015562 ENSUAMP00000015723 ENSUAMP00000015723 IPO8 IPO8 PYCR3 PYCR3 ENSUAMP00000016658 ENSUAMP00000016658 ENSUAMP00000017059 ENSUAMP00000017059 GPD1 GPD1 ENSUAMP00000017600 ENSUAMP00000017600 ENSUAMP00000017612 ENSUAMP00000017612 MOCOS MOCOS OGDH OGDH ENSUAMP00000018005 ENSUAMP00000018005 SUOX SUOX NDUFS7 NDUFS7 ENSUAMP00000018569 ENSUAMP00000018569 NOXA1 NOXA1 ENSUAMP00000018707 ENSUAMP00000018707 UQCR10 UQCR10 ENSUAMP00000020368 ENSUAMP00000020368 OGDHL OGDHL ENSUAMP00000020992 ENSUAMP00000020992 NDUFAB1 NDUFAB1 P4HB P4HB DBT DBT NCF2 NCF2 NDUFV2 NDUFV2 ENSUAMP00000023210 ENSUAMP00000023210 ETFB ETFB DLAT DLAT ENSUAMP00000023721 ENSUAMP00000023721 UQCRC1 UQCRC1 MRS2 MRS2 NDUFB2 NDUFB2 PSTK PSTK NOXO1 NOXO1 ENSUAMP00000024903 ENSUAMP00000024903 ENSUAMP00000024931 ENSUAMP00000024931 MRPS36 MRPS36 CBR4 CBR4 ALOX5 ALOX5 ENSUAMP00000025782 ENSUAMP00000025782 ALKBH6 ALKBH6 NDUFB6 NDUFB6 PDHX PDHX TSSK2 TSSK2 ENSUAMP00000027510 ENSUAMP00000027510 ENSUAMP00000027773 ENSUAMP00000027773 RRM2 RRM2 NOX3 NOX3 ENSUAMP00000028021 ENSUAMP00000028021 ENSUAMP00000028798 ENSUAMP00000028798 ENSUAMP00000028954 ENSUAMP00000028954 ENSUAMP00000029474 ENSUAMP00000029474 ENSUAMP00000029554 ENSUAMP00000029554 NDUFS4 NDUFS4 NDUFA10 NDUFA10 ENSUAMP00000030397 ENSUAMP00000030397 ENSUAMP00000030699 ENSUAMP00000030699 CLPB CLPB UQCRFS1 UQCRFS1 ENSUAMP00000030994 ENSUAMP00000030994 PDK1 PDK1 PDHA1 PDHA1 GMPR2 GMPR2 SDHB SDHB ENSUAMP00000032194 ENSUAMP00000032194 XK XK CYBB CYBB DUOX1 DUOX1 DUOXA2 DUOXA2 DUOX2 DUOX2 FAH FAH GPD2 GPD2 ETFA ETFA ARHGEF4 ARHGEF4 ENSUAMP00000032762 ENSUAMP00000032762 ENSUAMP00000033338 ENSUAMP00000033338 ENSUAMP00000033428 ENSUAMP00000033428 NDUFS2 NDUFS2 ETFDH ETFDH MARC2 MARC2 ENSUAMP00000033988 ENSUAMP00000033988 UQCRQ UQCRQ NDUFB11 NDUFB11 CYB5R3 CYB5R3 ENSUAMP00000034778 ENSUAMP00000034778 NOX1 NOX1 XKRX XKRX ENSUAMP00000035339 ENSUAMP00000035339 PDK2 PDK2 PDHB PDHB ENSUAMP00000035973 ENSUAMP00000035973 GPX8 GPX8 ENSUAMP00000036718 ENSUAMP00000036718 ENSUAMP00000036878 ENSUAMP00000036878 PPAT PPAT ENSUAMP00000037086 ENSUAMP00000037086 PDHA2 PDHA2 MTERF3 MTERF3 NDUFS3 NDUFS3 UQCRB UQCRB ENSUAMP00000000384 ENSUAMP00000000384 MTAP MTAP NDUFA13 NDUFA13 YJEFN3 YJEFN3 NDUFV3 NDUFV3 ENSUAMP00000001149 ENSUAMP00000001149 ENSUAMP00000001521 ENSUAMP00000001521 GPX7 GPX7 ENSUAMP00000003947 ENSUAMP00000003947 GMPR GMPR ENSUAMP00000004451 ENSUAMP00000004451 GLDC GLDC GPX2 GPX2 NCF4 NCF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000023031Uncharacterized protein. (118 aa)
ENSUAMP00000005324FMN hydroxy acid dehydrogenase domain-containing protein. (188 aa)
PFASPhosphoribosylformylglycinamidine synthase. (1338 aa)
ENSUAMP00000005938Uncharacterized protein. (84 aa)
ENSUAMP00000005950SERPIN domain-containing protein; Belongs to the serpin family. (366 aa)
NDUFB4NADH:ubiquinone oxidoreductase subunit B4. (129 aa)
FOXRED1FAD dependent oxidoreductase domain containing 1. (486 aa)
ENSUAMP00000006504Uncharacterized protein. (101 aa)
ENSUAMP00000006524Peptidase_M16_C domain-containing protein. (384 aa)
ENSUAMP00000007578ACAS_N domain-containing protein. (194 aa)
ENSUAMP00000007782Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (156 aa)
ENSUAMP00000007787Uncharacterized protein. (2431 aa)
AMTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (318 aa)
RSU1Ras suppressor protein 1. (201 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
NCF1Neutrophil cytosolic factor 1. (396 aa)
ENSUAMP00000011085Uncharacterized protein. (53 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1. (459 aa)
ENSUAMP00000011673EF-hand domain-containing protein; Belongs to the S-100 family. (87 aa)
ENSUAMP00000011699NAD_Gly3P_dh_C domain-containing protein. (117 aa)
ENSUAMP00000012006Uncharacterized protein. (255 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
DMAC2Distal membrane arm assembly complex 2. (289 aa)
ENSUAMP000000124762-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (466 aa)
NDUFA6NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (128 aa)
ENSUAMP000000125382-oxoacid_dh domain-containing protein. (170 aa)
ENSUAMP00000012541Uncharacterized protein. (98 aa)
ENSUAMP00000012629Uncharacterized protein. (211 aa)
GLOD5Glyoxalase domain containing 5. (189 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (492 aa)
DHDHDihydrodiol dehydrogenase. (335 aa)
ENSUAMP00000014276Uncharacterized protein. (118 aa)
NDUFC1NADH:ubiquinone oxidoreductase subunit C1. (76 aa)
ENSUAMP00000014576Fe2OG dioxygenase domain-containing protein. (244 aa)
ENSUAMP00000014708UCR_hinge domain-containing protein. (100 aa)
ENSUAMP00000015562Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (471 aa)
ENSUAMP00000015723Uncharacterized protein. (179 aa)
IPO8Importin 8. (847 aa)
PYCR3Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (276 aa)
ENSUAMP00000016658Uncharacterized protein. (84 aa)
ENSUAMP000000170592-oxoacid_dh domain-containing protein. (248 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
ENSUAMP00000017600Uncharacterized protein. (136 aa)
ENSUAMP00000017612zf-CHCC domain-containing protein. (117 aa)
MOCOSMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (791 aa)
OGDHOxoglutarate dehydrogenase. (1083 aa)
ENSUAMP00000018005Uncharacterized protein. (86 aa)
SUOXSulfite oxidase; Belongs to the cytochrome b5 family. (488 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (216 aa)
ENSUAMP00000018569Uncharacterized protein. (56 aa)
NOXA1NADPH oxidase activator 1. (467 aa)
ENSUAMP00000018707SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
UQCR10Ubiquinol-cytochrome c reductase, complex III subunit X. (64 aa)
ENSUAMP00000020368Peptidase_M16 domain-containing protein. (119 aa)
OGDHLOxoglutarate dehydrogenase like. (1025 aa)
ENSUAMP00000020992ATP-cone domain-containing protein. (123 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (154 aa)
P4HBProtein disulfide-isomerase. (510 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
NCF2Neutrophil cytosolic factor 2. (517 aa)
NDUFV2NADH:ubiquinone oxidoreductase core subunit V2. (249 aa)
ENSUAMP00000023210Uncharacterized protein. (196 aa)
ETFBElectron transfer flavoprotein subunit beta. (255 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
ENSUAMP00000023721Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (481 aa)
MRS2Magnesium transporter. (443 aa)
NDUFB2NADH:ubiquinone oxidoreductase subunit B2. (105 aa)
PSTKPhosphoseryl-tRNA kinase. (358 aa)
NOXO1NADPH oxidase organizer 1. (391 aa)
ENSUAMP00000024903Uncharacterized protein. (210 aa)
ENSUAMP00000024931Uncharacterized protein. (162 aa)
MRPS36Mitochondrial ribosomal protein S36. (102 aa)
CBR4Carbonyl reductase 4. (237 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
ENSUAMP00000025782Uncharacterized protein. (257 aa)
ALKBH6AlkB homolog 6. (262 aa)
NDUFB6NADH:ubiquinone oxidoreductase subunit B6. (97 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
TSSK2Testis specific serine kinase 2; Belongs to the protein kinase superfamily. (362 aa)
ENSUAMP00000027510zf-CHCC domain-containing protein. (124 aa)
ENSUAMP00000027773Uncharacterized protein. (116 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (297 aa)
NOX3NADPH oxidase 3. (567 aa)
ENSUAMP00000028021Uncharacterized protein. (135 aa)
ENSUAMP00000028798Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
ENSUAMP00000028954Uncharacterized protein. (177 aa)
ENSUAMP00000029474Uncharacterized protein. (141 aa)
ENSUAMP00000029554Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (159 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (175 aa)
NDUFA10NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (355 aa)
ENSUAMP00000030397NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (145 aa)
ENSUAMP00000030699NAD_Gly3P_dh_N domain-containing protein. (180 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (677 aa)
UQCRFS1Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa)
ENSUAMP00000030994Uncharacterized protein. (72 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (254 aa)
ENSUAMP00000032194Uncharacterized protein. (104 aa)
XKXK-related protein. (433 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
DUOX1Dual oxidase 1. (1539 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
DUOX2Dual oxidase 2. (1531 aa)
FAHFumarylacetoacetase. (419 aa)
GPD2Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (699 aa)
ETFAElectron transfer flavoprotein subunit alpha. (333 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (483 aa)
ENSUAMP00000032762Uncharacterized protein. (81 aa)
ENSUAMP00000033338NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (98 aa)
ENSUAMP00000033428Uncharacterized protein. (169 aa)
NDUFS2NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (533 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (617 aa)
MARC2Mitochondrial amidoxime reducing component 2. (311 aa)
ENSUAMP00000033988MOSC domain-containing protein. (270 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
NDUFB11NADH:ubiquinone oxidoreductase subunit B11. (154 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa)
ENSUAMP00000034778Uncharacterized protein. (361 aa)
NOX1NADPH oxidase 1. (594 aa)
XKRXXK-related protein. (449 aa)
ENSUAMP00000035339Uncharacterized protein. (80 aa)
PDK2Protein-serine/threonine kinase. (249 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
ENSUAMP00000035973Uncharacterized protein. (76 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
ENSUAMP00000036718Protein kinase domain-containing protein. (350 aa)
ENSUAMP00000036878Uncharacterized protein. (61 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (551 aa)
ENSUAMP00000037086Uncharacterized protein. (118 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
MTERF3Mitochondrial transcription termination factor 3. (414 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (337 aa)
UQCRBCytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (111 aa)
ENSUAMP00000000384NAD_binding_6 domain-containing protein. (147 aa)
MTAPS-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (255 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
YJEFN3YjeF N-terminal domain-containing protein. (250 aa)
NDUFV3NADH:ubiquinone oxidoreductase subunit V3. (435 aa)
ENSUAMP00000001149FMN hydroxy acid dehydrogenase domain-containing protein. (102 aa)
ENSUAMP00000001521Lipoyl-binding domain-containing protein. (129 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
ENSUAMP00000003947Protein S100; Belongs to the S-100 family. (130 aa)
GMPRGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (291 aa)
ENSUAMP00000004451IMPDH domain-containing protein. (161 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (991 aa)
GPX2Glutathione peroxidase 2. (175 aa)
NCF4Neutrophil cytosolic factor 4. (338 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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