(24 nodes) Death domain network (Ursus americanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	EDARADD	EDAR associated death domain. (193 aa)
	ENSUAMP00000011388	Uncharacterized protein. (334 aa)
	ANKDD1B	Ankyrin repeat and death domain containing 1B. (511 aa)
	TNFRSF25	TNF receptor superfamily member 25. (415 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (581 aa)
	THOC1	THO complex 1. (792 aa)
	UNC5B	Unc-5 netrin receptor B. (948 aa)
	PIDD1	P53-induced death domain protein 1. (911 aa)
	UNC5CL	Unc-5 family C-terminal like. (518 aa)
	ENSUAMP00000036338	Uncharacterized protein. (747 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (577 aa)
	ENSUAMP00000033520	Death domain-containing protein. (248 aa)
	UNC5C	Unc-5 netrin receptor C. (927 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (621 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (502 aa)
	UNC5A	Unc-5 netrin receptor A. (898 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
	NGFR	Nerve growth factor receptor. (388 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (972 aa)
	TRADD	TNFRSF1A associated via death domain. (314 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (550 aa)
	ANK2	Uncharacterized protein. (3158 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUAMP00000033520	FADD	ENSUAMP00000033520	ENSUAMP00000027565	Death domain-containing protein.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.737
ENSUAMP00000033520	NGFR	ENSUAMP00000033520	ENSUAMP00000023611	Death domain-containing protein.	Nerve growth factor receptor.	0.472
ENSUAMP00000033520	PIDD1	ENSUAMP00000033520	ENSUAMP00000028667	Death domain-containing protein.	P53-induced death domain protein 1.	0.517
ENSUAMP00000036338	FADD	ENSUAMP00000036338	ENSUAMP00000027565	Uncharacterized protein.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.440
FADD	ENSUAMP00000033520	ENSUAMP00000027565	ENSUAMP00000033520	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Death domain-containing protein.	0.737
FADD	ENSUAMP00000036338	ENSUAMP00000027565	ENSUAMP00000036338	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Uncharacterized protein.	0.440
FADD	MYD88	ENSUAMP00000027565	ENSUAMP00000006018	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.976
FADD	NGFR	ENSUAMP00000027565	ENSUAMP00000023611	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Nerve growth factor receptor.	0.919
FADD	PIDD1	ENSUAMP00000027565	ENSUAMP00000028667	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	P53-induced death domain protein 1.	0.522
FADD	RIPK1	ENSUAMP00000027565	ENSUAMP00000019468	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.999
FADD	TNFRSF1A	ENSUAMP00000027565	ENSUAMP00000029260	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor superfamily member 1A.	0.991
FADD	TNFRSF25	ENSUAMP00000027565	ENSUAMP00000009505	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor superfamily member 25.	0.694
FADD	TRADD	ENSUAMP00000027565	ENSUAMP00000019860	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNFRSF1A associated via death domain.	0.999
IRAK2	IRAK3	ENSUAMP00000032376	ENSUAMP00000034044	Interleukin 1 receptor associated kinase 2.	Interleukin 1 receptor associated kinase 3.	0.963
IRAK2	MYD88	ENSUAMP00000032376	ENSUAMP00000006018	Interleukin 1 receptor associated kinase 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.987
IRAK2	NFKB1	ENSUAMP00000032376	ENSUAMP00000021424	Interleukin 1 receptor associated kinase 2.	Nuclear factor kappa B subunit 1.	0.445
IRAK2	NFKB2	ENSUAMP00000032376	ENSUAMP00000005574	Interleukin 1 receptor associated kinase 2.	Nuclear factor kappa B subunit 2.	0.466
IRAK2	NGFR	ENSUAMP00000032376	ENSUAMP00000023611	Interleukin 1 receptor associated kinase 2.	Nerve growth factor receptor.	0.954
IRAK2	RIPK1	ENSUAMP00000032376	ENSUAMP00000019468	Interleukin 1 receptor associated kinase 2.	Receptor interacting serine/threonine kinase 1.	0.417
IRAK3	IRAK2	ENSUAMP00000034044	ENSUAMP00000032376	Interleukin 1 receptor associated kinase 3.	Interleukin 1 receptor associated kinase 2.	0.963