(17 nodes) Adenylyl cyclase class-3/4/guanylyl cyclase network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000000303	Guanylate cyclase domain-containing protein. (118 aa)
	ENSUAMP00000036508	Guanylate cyclase domain-containing protein. (363 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	ENSUAMP00000029679	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (540 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ADCY5	Adenylate cyclase 5. (940 aa)
	NPR1	Guanylate cyclase. (1115 aa)
	NPR2	Guanylate cyclase. (1048 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	GUCY2D	Guanylate cyclase. (1112 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1338 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (681 aa)
	ENSUAMP00000000325	Guanylate cyclase domain-containing protein. (150 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSUAMP00000028025	ENSUAMP00000008551	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY3	ENSUAMP00000028025	ENSUAMP00000008710	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY1	ADCY4	ENSUAMP00000028025	ENSUAMP00000032005	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.559
ADCY1	ADCY5	ENSUAMP00000028025	ENSUAMP00000027941	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.539
ADCY1	ADCY6	ENSUAMP00000028025	ENSUAMP00000035722	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY7	ENSUAMP00000028025	ENSUAMP00000032396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.666
ADCY1	ADCY9	ENSUAMP00000028025	ENSUAMP00000005924	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.646
ADCY1	ENSUAMP00000036508	ENSUAMP00000028025	ENSUAMP00000036508	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein.	0.424
ADCY2	ADCY1	ENSUAMP00000008551	ENSUAMP00000028025	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY2	ADCY4	ENSUAMP00000008551	ENSUAMP00000032005	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.538
ADCY2	ADCY5	ENSUAMP00000008551	ENSUAMP00000027941	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.991
ADCY2	ADCY6	ENSUAMP00000008551	ENSUAMP00000035722	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.861
ADCY2	ADCY7	ENSUAMP00000008551	ENSUAMP00000032396	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.540
ADCY2	ADCY9	ENSUAMP00000008551	ENSUAMP00000005924	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.678
ADCY3	ADCY1	ENSUAMP00000008710	ENSUAMP00000028025	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.931
ADCY3	ADCY4	ENSUAMP00000008710	ENSUAMP00000032005	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.554
ADCY3	ADCY5	ENSUAMP00000008710	ENSUAMP00000027941	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.567
ADCY3	ADCY6	ENSUAMP00000008710	ENSUAMP00000035722	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.947
ADCY3	ADCY7	ENSUAMP00000008710	ENSUAMP00000032396	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.555
ADCY3	ADCY9	ENSUAMP00000008710	ENSUAMP00000005924	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.954