STRINGSTRING
CELA1 CELA1 F2 F2 TMPRSS2 TMPRSS2 PRSS12 PRSS12 TMPRSS15 TMPRSS15 GZMA GZMA GZMK GZMK MASP1 MASP1 ENSUAMP00000031793 ENSUAMP00000031793 C2 C2 ENSUAMP00000032336 ENSUAMP00000032336 C1RL C1RL C1R C1R C1S C1S F12 F12 ENSUAMP00000028610 ENSUAMP00000028610 KLK15 KLK15 ENSUAMP00000028605 ENSUAMP00000028605 KLK4 KLK4 KLK5 KLK5 KLK6 KLK6 KLK7 KLK7 ENSUAMP00000028568 ENSUAMP00000028568 KLK10 KLK10 KLK11 KLK11 KLK12 KLK12 KLK13 KLK13 ENSUAMP00000028534 ENSUAMP00000028534 PAMR1 PAMR1 CTRL CTRL PRSS56 PRSS56 HGFAC HGFAC ENSUAMP00000026363 ENSUAMP00000026363 ENSUAMP00000026353 ENSUAMP00000026353 CTRC CTRC PRSS57 PRSS57 TMPRSS6 TMPRSS6 PRSS48 PRSS48 PRSS58 PRSS58 ENSUAMP00000023929 ENSUAMP00000023929 ENSUAMP00000023928 ENSUAMP00000023928 ENSUAMP00000023927 ENSUAMP00000023927 ENSUAMP00000023087 ENSUAMP00000023087 PRSS55 PRSS55 PRSS33 PRSS33 TMPRSS5 TMPRSS5 PRSS37 PRSS37 ENSUAMP00000022426 ENSUAMP00000022426 ENSUAMP00000022425 ENSUAMP00000022425 ENSUAMP00000022405 ENSUAMP00000022405 PRSS38 PRSS38 F11 F11 KLKB1 KLKB1 ENSUAMP00000019361 ENSUAMP00000019361 TMPRSS3 TMPRSS3 PLAU PLAU ENSUAMP00000017705 ENSUAMP00000017705 ENSUAMP00000016651 ENSUAMP00000016651 PRSS27 PRSS27 PRSS22 PRSS22 TMPRSS12 TMPRSS12 ENSUAMP00000016346 ENSUAMP00000016346 ENSUAMP00000016287 ENSUAMP00000016287 ENSUAMP00000016138 ENSUAMP00000016138 ENSUAMP00000015967 ENSUAMP00000015967 PROC PROC ENSUAMP00000015200 ENSUAMP00000015200 F7 F7 F10 F10 ENSUAMP00000012871 ENSUAMP00000012871 TMPRSS11B TMPRSS11B TMPRSS11E TMPRSS11E ENSUAMP00000011981 ENSUAMP00000011981 ENSUAMP00000011282 ENSUAMP00000011282 F9 F9 PRSS53 PRSS53 PRSS8 PRSS8 PRSS36 PRSS36 HABP2 HABP2 OVCH2 OVCH2 CMA1 CMA1 ENSUAMP00000008129 ENSUAMP00000008129 CTSG CTSG ENSUAMP00000007477 ENSUAMP00000007477 GZMH GZMH TMPRSS11F TMPRSS11F ENSUAMP00000007150 ENSUAMP00000007150 PLG PLG GZMB GZMB CFD CFD ELANE ELANE HPN HPN TMPRSS13 TMPRSS13 TMPRSS4 TMPRSS4 ENSUAMP00000002314 ENSUAMP00000002314 ACR ACR ENSUAMP00000000909 ENSUAMP00000000909 ENSUAMP00000000817 ENSUAMP00000000817 PLAT PLAT PRSS45P PRSS45P ENSUAMP00000033541 ENSUAMP00000033541 ENSUAMP00000033544 ENSUAMP00000033544 ENSUAMP00000033546 ENSUAMP00000033546
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (258 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (602 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (874 aa)
TMPRSS15Transmembrane serine protease 15; Belongs to the peptidase S1 family. (1003 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (258 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (257 aa)
MASP1Mannan binding lectin serine peptidase 1. (705 aa)
ENSUAMP00000031793Uncharacterized protein; Belongs to the peptidase S1 family. (768 aa)
C2Complement C2; Belongs to the peptidase S1 family. (743 aa)
ENSUAMP00000032336Uncharacterized protein; Belongs to the peptidase S1 family. (578 aa)
C1RLComplement C1r subcomponent like; Belongs to the peptidase S1 family. (538 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (713 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (695 aa)
F12Coagulation factor XII. (609 aa)
ENSUAMP00000028610Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (261 aa)
KLK15Kallikrein related peptidase 15; Belongs to the peptidase S1 family. (259 aa)
ENSUAMP00000028605Peptidase S1 domain-containing protein. (268 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (209 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (205 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (255 aa)
KLK7Kallikrein related peptidase 7; Belongs to the peptidase S1 family. (252 aa)
ENSUAMP00000028568Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
KLK10Kallikrein related peptidase 10; Belongs to the peptidase S1 family. (278 aa)
KLK11Kallikrein related peptidase 11; Belongs to the peptidase S1 family. (256 aa)
KLK12Kallikrein related peptidase 12; Belongs to the peptidase S1 family. (248 aa)
KLK13Kallikrein related peptidase 13; Belongs to the peptidase S1 family. (278 aa)
ENSUAMP00000028534Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (212 aa)
PAMR1Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family. (728 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (264 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (606 aa)
HGFACHGF activator. (656 aa)
ENSUAMP00000026363Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (271 aa)
ENSUAMP00000026353Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. (346 aa)
CTRCChymotrypsin C; Belongs to the peptidase S1 family. (278 aa)
PRSS57Serine protease 57; Belongs to the peptidase S1 family. (330 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (800 aa)
PRSS48Serine protease 48; Belongs to the peptidase S1 family. (303 aa)
PRSS58Serine protease 58; Belongs to the peptidase S1 family. (233 aa)
ENSUAMP00000023929Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (242 aa)
ENSUAMP00000023928Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
ENSUAMP00000023927Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (203 aa)
ENSUAMP00000023087Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (383 aa)
PRSS55Serine protease 55; Belongs to the peptidase S1 family. (340 aa)
PRSS33Serine protease 33; Belongs to the peptidase S1 family. (263 aa)
TMPRSS5Transmembrane serine protease 5; Belongs to the peptidase S1 family. (348 aa)
PRSS37Serine protease 37. (236 aa)
ENSUAMP00000022426Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (243 aa)
ENSUAMP00000022425Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (254 aa)
ENSUAMP00000022405Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
PRSS38Serine protease 38; Belongs to the peptidase S1 family. (331 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (625 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (634 aa)
ENSUAMP00000019361Uncharacterized protein; Belongs to the peptidase S1 family. (329 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (444 aa)
PLAUPlasminogen activator, urokinase; Belongs to the peptidase S1 family. (432 aa)
ENSUAMP00000017705Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
ENSUAMP00000016651Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (287 aa)
PRSS27Serine protease 27; Belongs to the peptidase S1 family. (322 aa)
PRSS22Serine protease 22; Belongs to the peptidase S1 family. (292 aa)
TMPRSS12Transmembrane serine protease 12; Belongs to the peptidase S1 family. (340 aa)
ENSUAMP00000016346Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (364 aa)
ENSUAMP00000016287Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (348 aa)
ENSUAMP00000016138Transmembrane protease serine; Belongs to the peptidase S1 family. (392 aa)
ENSUAMP00000015967Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (258 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (477 aa)
ENSUAMP00000015200Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (315 aa)
F7Coagulation factor VII. (446 aa)
F10Coagulation factor X. (487 aa)
ENSUAMP00000012871Transmembrane protease serine; Belongs to the peptidase S1 family. (414 aa)
TMPRSS11BTransmembrane serine protease 11B; Belongs to the peptidase S1 family. (387 aa)
TMPRSS11ETransmembrane protease serine; Belongs to the peptidase S1 family. (392 aa)
ENSUAMP00000011981Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (387 aa)
ENSUAMP00000011282Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (359 aa)
F9Coagulation factor IX. (460 aa)
PRSS53Serine protease 53; Belongs to the peptidase S1 family. (544 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (331 aa)
PRSS36Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. (843 aa)
HABP2Hyaluronan binding protein 2. (556 aa)
OVCH2Ovochymase 2 (gene/pseudogene); Belongs to the peptidase S1 family. (579 aa)
CMA1Chymase 1; Belongs to the peptidase S1 family. (247 aa)
ENSUAMP00000008129Peptidase S1 domain-containing protein. (279 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (285 aa)
ENSUAMP00000007477Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (253 aa)
GZMHGranzyme H; Belongs to the peptidase S1 family. (250 aa)
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (435 aa)
ENSUAMP00000007150Transmembrane protease serine; Belongs to the peptidase S1 family. (415 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (260 aa)
CFDComplement factor D; Belongs to the peptidase S1 family. (259 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (264 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
TMPRSS13Transmembrane serine protease 13; Belongs to the peptidase S1 family. (506 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (427 aa)
ENSUAMP00000002314Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (301 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (400 aa)
ENSUAMP00000000909Uncharacterized protein; Belongs to the peptidase S1 family. (614 aa)
ENSUAMP00000000817Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (369 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
PRSS45PSerine protease 45, pseudogene; Belongs to the peptidase S1 family. (258 aa)
ENSUAMP00000033541Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (381 aa)
ENSUAMP00000033544Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (374 aa)
ENSUAMP00000033546Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (359 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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