(7 nodes) Death effector domain network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000007992	Uncharacterized protein. (219 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (481 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (395 aa)
	DEDD2	Death effector domain containing 2. (327 aa)
	PEA15	Proliferation and apoptosis adaptor protein 15. (130 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
	DEDD	Death effector domain containing. (318 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP10	CASP8	ENSUAMP00000007994	ENSUAMP00000007996	Caspase 10; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.983
CASP10	ENSUAMP00000007992	ENSUAMP00000007994	ENSUAMP00000007992	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.986
CASP10	FADD	ENSUAMP00000007994	ENSUAMP00000027565	Caspase 10; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.997
CASP8	CASP10	ENSUAMP00000007996	ENSUAMP00000007994	Caspase 8; Belongs to the peptidase C14A family.	Caspase 10; Belongs to the peptidase C14A family.	0.983
CASP8	ENSUAMP00000007992	ENSUAMP00000007996	ENSUAMP00000007992	Caspase 8; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.986
CASP8	FADD	ENSUAMP00000007996	ENSUAMP00000027565	Caspase 8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
DEDD	PEA15	ENSUAMP00000033469	ENSUAMP00000025620	Death effector domain containing.	Proliferation and apoptosis adaptor protein 15.	0.427
ENSUAMP00000007992	CASP10	ENSUAMP00000007992	ENSUAMP00000007994	Uncharacterized protein.	Caspase 10; Belongs to the peptidase C14A family.	0.986
ENSUAMP00000007992	CASP8	ENSUAMP00000007992	ENSUAMP00000007996	Uncharacterized protein.	Caspase 8; Belongs to the peptidase C14A family.	0.986
ENSUAMP00000007992	FADD	ENSUAMP00000007992	ENSUAMP00000027565	Uncharacterized protein.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.991
FADD	CASP10	ENSUAMP00000027565	ENSUAMP00000007994	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 10; Belongs to the peptidase C14A family.	0.997
FADD	CASP8	ENSUAMP00000027565	ENSUAMP00000007996	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 8; Belongs to the peptidase C14A family.	0.999
FADD	ENSUAMP00000007992	ENSUAMP00000027565	ENSUAMP00000007992	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Uncharacterized protein.	0.991
FADD	PEA15	ENSUAMP00000027565	ENSUAMP00000025620	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Proliferation and apoptosis adaptor protein 15.	0.532
PEA15	DEDD	ENSUAMP00000025620	ENSUAMP00000033469	Proliferation and apoptosis adaptor protein 15.	Death effector domain containing.	0.427
PEA15	FADD	ENSUAMP00000025620	ENSUAMP00000027565	Proliferation and apoptosis adaptor protein 15.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.532