43 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000017983	RHD domain-containing protein. (473 aa)
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (537 aa)
	TBX22	T-box transcription factor 22. (524 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (972 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (444 aa)
	TBX18	T-box transcription factor 18. (612 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (408 aa)
	NFATC3	Nuclear factor of activated T cells 3. (1079 aa)
	EOMES	Eomesodermin. (687 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
	TBX1	T-box transcription factor 1. (464 aa)
	STAT5A	Signal transducer and activator of transcription. (797 aa)
	ENSUAMP00000013825	RHD domain-containing protein. (119 aa)
	ENSUAMP00000012729	RHD domain-containing protein. (481 aa)
	MYRFL	Myelin regulatory factor like. (904 aa)
	TBX10	T-box transcription factor 10. (388 aa)
	NFATC1	Nuclear factor of activated T cells 1. (931 aa)
	TBX19	T-box transcription factor 19. (444 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	NFATC4	Nuclear factor of activated T cells 4. (911 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	ENSUAMP00000004460	Runt domain-containing protein. (278 aa)
	ENSUAMP00000003509	LAG1_DNAbind domain-containing protein. (58 aa)
	TBX5	T-box transcription factor 5. (517 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	TBX4	T-box transcription factor 4. (529 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	STAT2	Signal transducer and activator of transcription. (848 aa)
	STAT1	Signal transducer and activator of transcription. (824 aa)
	ENSUAMP00000033199	RHD domain-containing protein. (458 aa)
	STAT4	Signal transducer and activator of transcription. (704 aa)
	TBX6	T-box transcription factor 6. (436 aa)
	STAT5B	Signal transducer and activator of transcription. (784 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (575 aa)
	MGA	MAX dimerization protein MGA. (3115 aa)
	TBXT	T-box transcription factor T. (435 aa)
	ENSUAMP00000027699	Uncharacterized protein. (214 aa)
	STAT6	Signal transducer and activator of transcription. (844 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (508 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	ENSUAMP00000025690	Runt domain-containing protein. (196 aa)
	TBX20	T-box transcription factor 20. (448 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUAMP00000000600	ENSUAMP00000027699	ENSUAMP00000000600	ENSUAMP00000027699	Uncharacterized protein.	Uncharacterized protein.	0.406
ENSUAMP00000003509	ENSUAMP00000004460	ENSUAMP00000003509	ENSUAMP00000004460	LAG1_DNAbind domain-containing protein.	Runt domain-containing protein.	0.421
ENSUAMP00000003509	RBPJL	ENSUAMP00000003509	ENSUAMP00000022544	LAG1_DNAbind domain-containing protein.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.873
ENSUAMP00000004460	ENSUAMP00000003509	ENSUAMP00000004460	ENSUAMP00000003509	Runt domain-containing protein.	LAG1_DNAbind domain-containing protein.	0.421
ENSUAMP00000004460	EOMES	ENSUAMP00000004460	ENSUAMP00000036778	Runt domain-containing protein.	Eomesodermin.	0.527
ENSUAMP00000004460	RBPJ	ENSUAMP00000004460	ENSUAMP00000020901	Runt domain-containing protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.421
ENSUAMP00000004460	TP53	ENSUAMP00000004460	ENSUAMP00000000913	Runt domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.684
ENSUAMP00000012729	ENSUAMP00000033199	ENSUAMP00000012729	ENSUAMP00000033199	RHD domain-containing protein.	RHD domain-containing protein.	0.916
ENSUAMP00000012729	NFATC1	ENSUAMP00000012729	ENSUAMP00000011379	RHD domain-containing protein.	Nuclear factor of activated T cells 1.	0.927
ENSUAMP00000012729	NFATC3	ENSUAMP00000012729	ENSUAMP00000020439	RHD domain-containing protein.	Nuclear factor of activated T cells 3.	0.919
ENSUAMP00000012729	NFATC4	ENSUAMP00000012729	ENSUAMP00000008284	RHD domain-containing protein.	Nuclear factor of activated T cells 4.	0.906
ENSUAMP00000013825	NFKB1	ENSUAMP00000013825	ENSUAMP00000021424	RHD domain-containing protein.	Nuclear factor kappa B subunit 1.	0.975
ENSUAMP00000013825	RELA	ENSUAMP00000013825	ENSUAMP00000026886	RHD domain-containing protein.	RELA proto-oncogene, NF-kB subunit.	0.975
ENSUAMP00000013825	RELB	ENSUAMP00000013825	ENSUAMP00000030557	RHD domain-containing protein.	RELB proto-oncogene, NF-kB subunit.	0.854
ENSUAMP00000013825	STAT3	ENSUAMP00000013825	ENSUAMP00000008772	RHD domain-containing protein.	Signal transducer and activator of transcription.	0.450
ENSUAMP00000025690	TP53	ENSUAMP00000025690	ENSUAMP00000000913	Runt domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.503
ENSUAMP00000027699	ENSUAMP00000000600	ENSUAMP00000027699	ENSUAMP00000000600	Uncharacterized protein.	Uncharacterized protein.	0.406
ENSUAMP00000033199	ENSUAMP00000012729	ENSUAMP00000033199	ENSUAMP00000012729	RHD domain-containing protein.	RHD domain-containing protein.	0.916
ENSUAMP00000033199	NFATC1	ENSUAMP00000033199	ENSUAMP00000011379	RHD domain-containing protein.	Nuclear factor of activated T cells 1.	0.904
ENSUAMP00000033199	NFATC3	ENSUAMP00000033199	ENSUAMP00000020439	RHD domain-containing protein.	Nuclear factor of activated T cells 3.	0.893