STRINGSTRING
SNRPD1 SNRPD1 ENSUAMP00000000623 ENSUAMP00000000623 LSM4 LSM4 LSM7 LSM7 ENSUAMP00000001138 ENSUAMP00000001138 ENSUAMP00000003643 ENSUAMP00000003643 ENSUAMP00000003688 ENSUAMP00000003688 LSM1 LSM1 ENSUAMP00000005079 ENSUAMP00000005079 NAA38 NAA38 SNRPB SNRPB ENSUAMP00000006861 ENSUAMP00000006861 LSM8 LSM8 LSM8-2 LSM8-2 SNRPF SNRPF SNRPD2 SNRPD2 ENSUAMP00000010072 ENSUAMP00000010072 LSM5 LSM5 SNRPE SNRPE SNRPD3 SNRPD3 LSM11 LSM11 LSM6 LSM6 SNRPN SNRPN ENSUAMP00000020708 ENSUAMP00000020708 LSM3 LSM3 LSM14A LSM14A LSM10 LSM10 ENSUAMP00000026187 ENSUAMP00000026187 ENSUAMP00000028028 ENSUAMP00000028028 SNRPD2-2 SNRPD2-2 SNRPD2-3 SNRPD2-3 LSM14B LSM14B ENSUAMP00000033911 ENSUAMP00000033911
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (117 aa)
ENSUAMP00000000623Uncharacterized protein. (86 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (120 aa)
ENSUAMP00000001138Sm domain-containing protein. (85 aa)
ENSUAMP00000003643Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (72 aa)
ENSUAMP00000003688Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (78 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
ENSUAMP00000005079Uncharacterized protein. (78 aa)
NAA38N(alpha)-acetyltransferase 38, NatC auxiliary subunit. (125 aa)
SNRPBSmall nuclear ribonucleoprotein-associated protein. (214 aa)
ENSUAMP00000006861Sm domain-containing protein. (52 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (92 aa)
LSM8-2U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
SNRPFSm domain-containing protein. (86 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (53 aa)
ENSUAMP00000010072Sm domain-containing protein. (105 aa)
LSM5LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated. (77 aa)
SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (88 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
LSM11LSM11, U7 small nuclear RNA associated. (335 aa)
LSM6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (122 aa)
SNRPNSmall nuclear ribonucleoprotein polypeptide N. (287 aa)
ENSUAMP00000020708Sm domain-containing protein. (74 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (114 aa)
LSM14ALSM14A mRNA processing body assembly factor. (481 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
ENSUAMP00000026187Sm domain-containing protein. (72 aa)
ENSUAMP00000028028Sm domain-containing protein. (48 aa)
SNRPD2-2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (123 aa)
SNRPD2-3Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
LSM14BLSM family member 14B. (420 aa)
ENSUAMP00000033911Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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