STRINGSTRING
FADD FADD IRAK1 IRAK1 BCL10 BCL10 NGFR NGFR RIPK2 RIPK2 CASP9 CASP9 NFKB1 NFKB1 IFIH1 IFIH1 NLRP12 NLRP12 CASP10 CASP10 CASP8 CASP8 UNC5D UNC5D TNFRSF25 TNFRSF25 ANKDD1B ANKDD1B PYCARD PYCARD ENSUAMP00000011223 ENSUAMP00000011223 ENSUAMP00000011388 ENSUAMP00000011388 CARD9 CARD9 ENSUAMP00000012080 ENSUAMP00000012080 NLRP3 NLRP3 ANK2 ANK2 CARD8 CARD8 DEDD2 DEDD2 EDAR EDAR EDARADD EDARADD ENSUAMP00000015403 ENSUAMP00000015403 BIRC2 BIRC2 BIRC3 BIRC3 RIPK1 RIPK1 TRADD TRADD NOL3 NOL3 DEDD DEDD ENSUAMP00000033520 ENSUAMP00000033520 IRAK3 IRAK3 NLRP8 NLRP8 NLRP13 NLRP13 MNDA MNDA ENSUAMP00000035084 ENSUAMP00000035084 IRAK4 IRAK4 MAVS MAVS CARD14 CARD14 ENSUAMP00000036338 ENSUAMP00000036338 UNC5CL UNC5CL DDX58 DDX58 IGFLR1 IGFLR1 UNC5C UNC5C CARD6 CARD6 ENSUAMP00000033323 ENSUAMP00000033323 CARD10 CARD10 ZBTB40 ZBTB40 UNC5A UNC5A ENSUAMP00000025950 ENSUAMP00000025950 ENSUAMP00000025829 ENSUAMP00000025829 PEA15 PEA15 NLRP9 NLRP9 TNFRSF11B TNFRSF11B ENSUAMP00000007992 ENSUAMP00000007992 MYD88 MYD88 NFKB2 NFKB2 THOC1 THOC1 ENSUAMP00000005106 ENSUAMP00000005106 UNC5B UNC5B ENSUAMP00000004351 ENSUAMP00000004351 IRAK2 IRAK2 CARD11 CARD11 TNFRSF1A TNFRSF1A PIDD1 PIDD1 NLRP1 NLRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (664 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
NGFRNerve growth factor receptor. (388 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
IFIH1Interferon induced with helicase C domain 1. (1017 aa)
NLRP12NLR family pyrin domain containing 12. (1054 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
UNC5DUnc-5 netrin receptor D. (965 aa)
TNFRSF25TNF receptor superfamily member 25. (415 aa)
ANKDD1BAnkyrin repeat and death domain containing 1B. (511 aa)
PYCARDPYD and CARD domain containing. (194 aa)
ENSUAMP00000011223Uncharacterized protein. (224 aa)
ENSUAMP00000011388Uncharacterized protein. (334 aa)
CARD9Caspase recruitment domain family member 9. (566 aa)
ENSUAMP00000012080Uncharacterized protein; Belongs to the peptidase C14A family. (409 aa)
NLRP3NLR family pyrin domain containing 3. (922 aa)
ANK2Uncharacterized protein. (3158 aa)
CARD8Caspase recruitment domain family member 8. (444 aa)
DEDD2Death effector domain containing 2. (327 aa)
EDAREctodysplasin A receptor. (475 aa)
EDARADDEDAR associated death domain. (193 aa)
ENSUAMP00000015403Uncharacterized protein. (492 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
NOL3Nucleolar protein 3. (222 aa)
DEDDDeath effector domain containing. (318 aa)
ENSUAMP00000033520Death domain-containing protein. (248 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (577 aa)
NLRP8NLR family pyrin domain containing 8. (1036 aa)
NLRP13NLR family pyrin domain containing 13. (1030 aa)
MNDAMyeloid cell nuclear differentiation antigen. (436 aa)
ENSUAMP00000035084Uncharacterized protein. (399 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (477 aa)
MAVSMitochondrial antiviral signaling protein. (523 aa)
CARD14Caspase recruitment domain family member 14. (1007 aa)
ENSUAMP00000036338Uncharacterized protein. (747 aa)
UNC5CLUnc-5 family C-terminal like. (518 aa)
DDX58DExD/H-box helicase 58. (928 aa)
IGFLR1IGF like family receptor 1. (315 aa)
UNC5CUnc-5 netrin receptor C. (927 aa)
CARD6Caspase recruitment domain family member 6. (1023 aa)
ENSUAMP00000033323CARD domain-containing protein. (221 aa)
CARD10Caspase recruitment domain family member 10. (1087 aa)
ZBTB40Zinc finger and BTB domain containing 40. (1250 aa)
UNC5AUnc-5 netrin receptor A. (898 aa)
ENSUAMP00000025950Uncharacterized protein. (304 aa)
ENSUAMP00000025829CARD domain-containing protein. (86 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (130 aa)
NLRP9NLR family pyrin domain containing 9. (983 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
ENSUAMP00000007992Uncharacterized protein. (219 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
NFKB2Nuclear factor kappa B subunit 2. (581 aa)
THOC1THO complex 1. (792 aa)
ENSUAMP00000005106Uncharacterized protein. (1026 aa)
UNC5BUnc-5 netrin receptor B. (948 aa)
ENSUAMP00000004351CARD domain-containing protein. (165 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
CARD11Caspase recruitment domain family member 11. (1123 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
PIDD1P53-induced death domain protein 1. (911 aa)
NLRP1NLR family pyrin domain containing 1. (1427 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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