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NODAL NODAL BMP10 BMP10 PDGFD PDGFD TGFB3 TGFB3 SOSTDC1 SOSTDC1 PGF PGF GDF11 GDF11 GREM2 GREM2 VEGFB VEGFB DAND5 DAND5 VEGFA VEGFA TGFB2 TGFB2 BMP2 BMP2 GDNF GDNF BMP6 BMP6 GPHB5 GPHB5 ENSUAMP00000022378 ENSUAMP00000022378 SOST SOST IL17A IL17A IL17F IL17F NBL1 NBL1 INHBC INHBC INHBE INHBE IL17B IL17B IL17C IL17C BMP4 BMP4 CER1 CER1 VEGFD VEGFD INHA INHA MSTN MSTN NGF NGF IL25 IL25 NRTN NRTN NTF3 NTF3 PDGFC PDGFC BMP15 BMP15 BMP3 BMP3 GDF9 GDF9 PSPN PSPN CGA CGA ENSUAMP00000037566 ENSUAMP00000037566 GDF2 GDF2 GDF10 GDF10 ENSUAMP00000000624 ENSUAMP00000000624 ENSUAMP00000001661 ENSUAMP00000001661 NOG NOG GREM1 GREM1 PDGFB PDGFB INHBA INHBA ENSUAMP00000008401 ENSUAMP00000008401 PDGFA PDGFA GDF5 GDF5 ENSUAMP00000012044 ENSUAMP00000012044 TGFB1 TGFB1 NDP NDP TSHB TSHB GPHA2 GPHA2 FSHB FSHB ENSUAMP00000014614 ENSUAMP00000014614 GDF3 GDF3 VEGFC VEGFC ENSUAMP00000013443 ENSUAMP00000013443 ENSUAMP00000013226 ENSUAMP00000013226
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NODALNodal growth differentiation factor. (348 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
PDGFDPlatelet derived growth factor D. (368 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
GDF11Growth differentiation factor 11. (409 aa)
GREM2Gremlin. (168 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (191 aa)
DAND5DAN domain BMP antagonist family member 5. (190 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
BMP6Bone morphogenetic protein 6. (384 aa)
GPHB5Glycoprotein hormone subunit beta 5. (130 aa)
ENSUAMP00000022378TGF_BETA_2 domain-containing protein. (155 aa)
SOSTSclerostin. (213 aa)
IL17AInterleukin 17A. (161 aa)
IL17FInterleukin 17F. (156 aa)
NBL1NBL1, DAN family BMP antagonist. (175 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (351 aa)
IL17BInterleukin 17B. (180 aa)
IL17CInterleukin 17C. (201 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CER1Cerberus 1, DAN family BMP antagonist. (279 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (329 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
MSTNMyostatin. (376 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (240 aa)
IL25Interleukin 25. (169 aa)
NRTNNeurturin. (157 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
PDGFCPlatelet derived growth factor C. (218 aa)
BMP15Bone morphogenetic protein 15. (402 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
GDF9Growth differentiation factor 9. (453 aa)
PSPNPersephin. (146 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
ENSUAMP00000037566TGF_BETA_2 domain-containing protein. (293 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDF10Growth differentiation factor 10. (483 aa)
ENSUAMP00000000624NGF domain-containing protein; Belongs to the NGF-beta family. (211 aa)
ENSUAMP00000001661TGF_BETA_2 domain-containing protein. (194 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
INHBAInhibin subunit beta A. (424 aa)
ENSUAMP00000008401TGF_BETA_2 domain-containing protein. (367 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (248 aa)
GDF5Growth differentiation factor 5. (499 aa)
ENSUAMP00000012044TGF_BETA_2 domain-containing protein. (154 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NDPNorrin cystine knot growth factor NDP. (112 aa)
TSHBThyroid stimulating hormone subunit beta. (138 aa)
GPHA2Glycoprotein hormone subunit alpha 2. (171 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
ENSUAMP00000014614Uncharacterized protein. (891 aa)
GDF3Growth differentiation factor 3. (365 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
ENSUAMP00000013443Uncharacterized protein. (670 aa)
ENSUAMP00000013226Cys_knot domain-containing protein. (140 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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