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ENSUAMP00000003899 ENSUAMP00000003899 ZDHHC20 ZDHHC20 ENSUAMP00000002128 ENSUAMP00000002128 CPT1B CPT1B ZDHHC17 ZDHHC17 NMT2 NMT2 ZDHHC9 ZDHHC9 GNPNAT1 GNPNAT1 ZDHHC7 ZDHHC7 ALAS2 ALAS2 ACAA1 ACAA1 ZDHHC12 ZDHHC12 ZDHHC13 ZDHHC13 ACAT1 ACAT1 CPT1C CPT1C HAT1 HAT1 ACAA2 ACAA2 HADHB HADHB LIPT2 LIPT2 ZDHHC14 ZDHHC14 CPT2 CPT2 ZDHHC16 ZDHHC16 GNPAT GNPAT OSGEP OSGEP OXSM OXSM ZDHHC8 ZDHHC8 NAT10 NAT10 OSGEPL1 OSGEPL1 ZDHHC5 ZDHHC5 ZDHHC2 ZDHHC2 ZDHHC22 ZDHHC22 ELP3 ELP3 ZDHHC24 ZDHHC24 ZDHHC1 ZDHHC1 ENSUAMP00000020181 ENSUAMP00000020181 CHAT CHAT AGPAT1 AGPAT1 GPAM GPAM DBT DBT ZDHHC23 ZDHHC23 DLAT DLAT SOAT1 SOAT1 AGPAT2 AGPAT2 ALAS1 ALAS1 PDHX PDHX ZDHHC21 ZDHHC21 PIGW PIGW ZDHHC4 ZDHHC4 CREBBP CREBBP NMT1 NMT1 KAT2A KAT2A EP300 EP300 CPT1A CPT1A ENSUAMP00000033423 ENSUAMP00000033423 ENSUAMP00000034502 ENSUAMP00000034502 CRAT CRAT ATE1 ATE1 ATAT1 ATAT1 DGAT1 DGAT1 ZDHHC19 ZDHHC19
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ENSUAMP00000003899Uncharacterized protein; Belongs to the arylamine N-acetyltransferase family. (290 aa)
ZDHHC20Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (302 aa)
ENSUAMP00000002128Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (180 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
ZDHHC17Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (536 aa)
NMT2Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (476 aa)
ZDHHC9Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (364 aa)
GNPNAT1Glucosamine 6-phosphate N-acetyltransferase. (184 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
ALAS25-aminolevulinate synthase. (587 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (414 aa)
ZDHHC12Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (295 aa)
ZDHHC13Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (616 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (378 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
LIPT2Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (231 aa)
ZDHHC14Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (488 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (659 aa)
ZDHHC16Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (377 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (679 aa)
OSGEPProbable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (335 aa)
OXSM3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa)
ZDHHC8Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (720 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1034 aa)
OSGEPL1Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (414 aa)
ZDHHC5Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (322 aa)
ZDHHC22Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (263 aa)
ELP3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (524 aa)
ZDHHC24Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (284 aa)
ZDHHC1Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (485 aa)
ENSUAMP00000020181Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (171 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (717 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (284 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
ZDHHC23Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (429 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
SOAT1O-acyltransferase. (513 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
ALAS15-aminolevulinate synthase. (640 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
PIGWPhosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (502 aa)
ZDHHC4Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (343 aa)
CREBBPCREB binding protein. (2333 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (485 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
EP300E1A binding protein p300. (2399 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
ENSUAMP00000033423Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (187 aa)
ENSUAMP00000034502Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (315 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (688 aa)
ATE1Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Belongs to the R-transferase family. (472 aa)
ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (421 aa)
DGAT1O-acyltransferase. (506 aa)
ZDHHC19Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (307 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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