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| | ASH1L | ASH1 like histone lysine methyltransferase. (2965 aa) |
| | KMT5B | Lysine methyltransferase 5B. (853 aa) |
| | NTMT1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1. (223 aa) |
| | ASMTL | Acetylserotonin O-methyltransferase like. (656 aa) |
| | MTR | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1178 aa) |
| | TFB1M | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (351 aa) |
| | KMT5C | Lysine methyltransferase 5C. (467 aa) |
| | LCMT1 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (333 aa) |
| | GNMT | Glycine N-methyltransferase. (295 aa) |
| | PRMT9 | Protein arginine methyltransferase 9; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (845 aa) |
| | PRMT3 | Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (516 aa) |
| | SETD3 | Protein-histidine N-methyltransferase. (591 aa) |
| | NNMT | Nicotinamide N-methyltransferase. (264 aa) |
| | NSUN5 | NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (485 aa) |
| | ENSUAMP00000020461 | SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (824 aa) |
| | PRMT7 | Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (694 aa) |
| | COQ5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (327 aa) |
| | CMTR2 | Cap methyltransferase 2. (771 aa) |
| | GAMT | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa) |
| | SETD1A | SET domain containing 1A, histone lysine methyltransferase. (1044 aa) |
| | ELP3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (524 aa) |
| | FTSJ1 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (336 aa) |
| | METTL1 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (277 aa) |
| | DIMT1 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (313 aa) |
| | PRMT2 | Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (408 aa) |
| | BMT2 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa) |
| | TRMT61A | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (351 aa) |
| | PRMT6 | Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa) |
| | COMT | Catechol-O-methyltransferase. (334 aa) |
| | TRMT2A | tRNA methyltransferase 2 homolog A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (621 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | RSAD1 | Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (442 aa) |
| | PRDM12 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (361 aa) |
| | PNMT | Phenylethanolamine N-methyltransferase. (283 aa) |
| | ENSUAMP00000011412 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (290 aa) |
| | SETD1B | SET domain containing 1B, histone lysine methyltransferase. (1824 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa) |
| | ENSUAMP00000009789 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3862 aa) |
| | PRMT1 | Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (353 aa) |
| | DNMT1 | DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (981 aa) |
| | CARM1 | Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (636 aa) |
| | PCMT1 | Protein-L-isoaspartate O-methyltransferase. (285 aa) |
| | PEMT | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (183 aa) |
| | BCDIN3D | BCDIN3 domain containing RNA methyltransferase. (292 aa) |
| | NSD3 | Nuclear receptor binding SET domain protein 3. (917 aa) |
| | NSUN4 | NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (384 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1344 aa) |
| | DPH5 | Diphthamide biosynthesis 5. (280 aa) |
| | SUV39H2 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (483 aa) |
| | RNMT | mRNA cap guanine-N7 methyltransferase. (478 aa) |
| | ENSUAMP00000036853 | Uncharacterized protein. (1459 aa) |
| | TRDMT1 | tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (387 aa) |
| | KMT2D | Lysine methyltransferase 2D. (5333 aa) |
| | SETDB1 | SET domain bifurcated histone lysine methyltransferase 1. (1299 aa) |
| | DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1520 aa) |
| | TRMT2B | tRNA methyltransferase 2 homolog B; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (532 aa) |
| | AMD1 | S-adenosylmethionine decarboxylase proenzyme. (334 aa) |
| | LIAS | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa) |
| | METTL11B | Methyltransferase like 11B. (256 aa) |
| | ENSUAMP00000001748 | FtsJ domain-containing protein. (245 aa) |
| | TRMT12 | tRNA methyltransferase 12 homolog. (436 aa) |
| | MEPCE | Methylphosphate capping enzyme. (653 aa) |
| | DPH2 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (489 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (457 aa) |
| | SETD2 | SET domain containing 2, histone lysine methyltransferase. (2520 aa) |
| | NSUN2 | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (799 aa) |
| | ICMT | Protein-S-isoprenylcysteine O-methyltransferase. (284 aa) |
| | ENSUAMP00000031700 | Uncharacterized protein. (301 aa) |
| | COQ3 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (370 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (862 aa) |
| | TRMT5 | tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (499 aa) |
| | TRMT1 | tRNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (673 aa) |
| | SETD7 | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa) |
| | PRMT8 | Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa) |
| | TRMT1L | tRNA methyltransferase 1 like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (735 aa) |
| | KMT2B | Lysine methyltransferase 2B. (2553 aa) |
| | KMT2C | Lysine methyltransferase 2C. (4697 aa) |
| | KMT5A | Lysine methyltransferase 5A. (327 aa) |
