15 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSTO1	Glutathione S-transferase omega 1; Belongs to the GST superfamily. (278 aa)
	MAT2B	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (324 aa)
	AHCY	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (445 aa)
	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (723 aa)
	COMT	Catechol-O-methyltransferase. (334 aa)
	N6AMT1	N-6 adenine-specific DNA methyltransferase 1. (214 aa)
	MAT1A	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
	TPMT	Thiopurine S-methyltransferase. (220 aa)
	ENSUAMP00000019210	Uncharacterized protein. (148 aa)
	NNMT	Nicotinamide N-methyltransferase. (264 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1178 aa)
	ENSUAMP00000023714	Uncharacterized protein. (125 aa)
	AS3MT	Arsenite methyltransferase. (457 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (512 aa)
	MAT2A	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHCY	MAT1A	ENSUAMP00000008225	ENSUAMP00000016137	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.745
AHCY	MAT2A	ENSUAMP00000008225	ENSUAMP00000036395	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.749
AHCY	MAT2B	ENSUAMP00000008225	ENSUAMP00000006314	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.437
AHCY	MTR	ENSUAMP00000008225	ENSUAMP00000023378	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.970
AS3MT	ENSUAMP00000019210	ENSUAMP00000035100	ENSUAMP00000019210	Arsenite methyltransferase.	Uncharacterized protein.	0.483
AS3MT	ENSUAMP00000023714	ENSUAMP00000035100	ENSUAMP00000023714	Arsenite methyltransferase.	Uncharacterized protein.	0.483
AS3MT	MAT2B	ENSUAMP00000035100	ENSUAMP00000006314	Arsenite methyltransferase.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.514
COMT	CYP1A2	ENSUAMP00000013555	ENSUAMP00000035169	Catechol-O-methyltransferase.	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family.	0.666
COMT	MAT1A	ENSUAMP00000013555	ENSUAMP00000016137	Catechol-O-methyltransferase.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.662
COMT	MAT2A	ENSUAMP00000013555	ENSUAMP00000036395	Catechol-O-methyltransferase.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.662
CYP1A2	COMT	ENSUAMP00000035169	ENSUAMP00000013555	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family.	Catechol-O-methyltransferase.	0.666
CYP1A2	GSTO1	ENSUAMP00000035169	ENSUAMP00000002571	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family.	Glutathione S-transferase omega 1; Belongs to the GST superfamily.	0.913
ENSUAMP00000019210	AS3MT	ENSUAMP00000019210	ENSUAMP00000035100	Uncharacterized protein.	Arsenite methyltransferase.	0.483
ENSUAMP00000019210	N6AMT1	ENSUAMP00000019210	ENSUAMP00000016097	Uncharacterized protein.	N-6 adenine-specific DNA methyltransferase 1.	0.988
ENSUAMP00000023714	AS3MT	ENSUAMP00000023714	ENSUAMP00000035100	Uncharacterized protein.	Arsenite methyltransferase.	0.483
ENSUAMP00000023714	N6AMT1	ENSUAMP00000023714	ENSUAMP00000016097	Uncharacterized protein.	N-6 adenine-specific DNA methyltransferase 1.	0.988
GSTO1	CYP1A2	ENSUAMP00000002571	ENSUAMP00000035169	Glutathione S-transferase omega 1; Belongs to the GST superfamily.	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family.	0.913
MAT1A	AHCY	ENSUAMP00000016137	ENSUAMP00000008225	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	0.745
MAT1A	COMT	ENSUAMP00000016137	ENSUAMP00000013555	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Catechol-O-methyltransferase.	0.662
MAT1A	MAT2A	ENSUAMP00000016137	ENSUAMP00000036395	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.962