(125 nodes) Signaling by NTRKs network (Ursus americanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (387 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
	ENSUAMP00000000624	NGF domain-containing protein; Belongs to the NGF-beta family. (211 aa)
	ENSUAMP00000000785	SH2 domain-containing protein. (91 aa)
	EGR2	Early growth response 2. (471 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	PPP4R1	Protein phosphatase 4 regulatory subunit 1. (937 aa)
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (334 aa)
	ENSUAMP00000003693	Uncharacterized protein. (166 aa)
	FNBP4	Formin binding protein 4. (1018 aa)
	ENSUAMP00000006374	Uncharacterized protein. (178 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (433 aa)
	FNDC3A	Fibronectin type III domain containing 3A. (1199 aa)
	RRAD	RRAD, Ras related glycolysis inhibitor and calcium channel regulator. (373 aa)
	SGK1	Serum/glucocorticoid regulated kinase 1. (437 aa)
	ENSUAMP00000008294	Clat_adaptor_s domain-containing protein. (92 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ENSUAMP00000009614	WRNPLPNID domain-containing protein. (950 aa)
	ENSUAMP00000010013	Uncharacterized protein. (73 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (213 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
	KIDINS220	Kinase D interacting substrate 220. (1499 aa)
	ENSUAMP00000010308	Uncharacterized protein. (854 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1010 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (676 aa)
	AP2B1	AP complex subunit beta. (893 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (753 aa)
	ENSUAMP00000011871	PLAC domain-containing protein. (308 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1234 aa)
	ENSUAMP00000011968	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1498 aa)
	ENSUAMP00000011971	Uncharacterized protein. (91 aa)
	ARC	Activity regulated cytoskeleton associated protein. (396 aa)
	GRB2	Growth factor receptor bound protein 2. (203 aa)
	RALB	RAS like proto-oncogene B. (206 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (589 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	ERAS	ES cell expressed Ras. (219 aa)
	ENSUAMP00000014440	Protein kinase domain-containing protein. (251 aa)
	IRS2	Insulin receptor substrate 2. (1089 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (836 aa)
	ENSUAMP00000015960	Tyrosine-protein phosphatase domain-containing protein. (326 aa)
	ENSUAMP00000015993	Uncharacterized protein. (98 aa)
	MAPK15	Mitogen-activated protein kinase. (680 aa)
	ENSUAMP00000016265	PID domain-containing protein. (219 aa)
	ATF1	Activating transcription factor 1. (270 aa)
	NAB1	NGFI-A binding protein 1. (486 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (393 aa)
	CRK	CRK proto-oncogene, adaptor protein. (204 aa)
	TRIB1	Tribbles pseudokinase 1. (317 aa)
	MAPK11	Mitogen-activated protein kinase. (357 aa)
	NTRK1	Tyrosine-protein kinase receptor. (787 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
	RIT1	Ras like without CAAX 1. (219 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (798 aa)
	ENSUAMP00000017692	Uncharacterized protein. (704 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	SHC1	SHC adaptor protein 1. (474 aa)
	TRIB2	Tribbles pseudokinase 2. (207 aa)
	PPP4R4	Protein phosphatase 4 regulatory subunit 4. (751 aa)
	SRF	Serum response factor. (507 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (935 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	AP2S1	Adaptor related protein complex 2 subunit sigma 1. (179 aa)
	ENSUAMP00000022131	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (636 aa)
	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (601 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (244 aa)
	ENSUAMP00000023088	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (208 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (824 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	EGR4	Early growth response 4. (484 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (728 aa)
	ENSUAMP00000025159	BZIP domain-containing protein. (314 aa)
	ENSUAMP00000025215	BZIP domain-containing protein. (347 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (777 aa)
	ENSUAMP00000025465	Uncharacterized protein. (94 aa)
	ENSUAMP00000025530	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (458 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (793 aa)
	DUSP7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
	ENSUAMP00000026993	Uncharacterized protein. (118 aa)
	NAB2	NGFI-A binding protein 2. (492 aa)
	NTRK2	Tyrosine-protein kinase receptor. (800 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	ELK1	ETS transcription factor ELK1. (435 aa)
	ENSUAMP00000028178	Uncharacterized protein. (311 aa)
	ENSUAMP00000028179	CSD domain-containing protein. (89 aa)
	DOCK3	Dedicator of cytokinesis 3; Belongs to the DOCK family. (1967 aa)
	ENSUAMP00000029031	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	IRS1	Insulin receptor substrate 1. (1237 aa)
	ENSUAMP00000029725	Uncharacterized protein. (1947 aa)
	LYL1	LYL1 basic helix-loop-helix family member. (280 aa)
	SRC	Tyrosine-protein kinase. (557 aa)
	ENSUAMP00000030280	Protein kinase domain-containing protein. (206 aa)
	MAP2K1	Protein kinase domain-containing protein. (216 aa)
	RPS6KA4	Ribosomal protein S6 kinase. (772 aa)
	RPS6KA3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (119 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	ASCL2	Achaete-scute family bHLH transcription factor 2. (194 aa)
	ENSUAMP00000031525	Uncharacterized protein. (79 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (240 aa)
	ENSUAMP00000031719	Uncharacterized protein. (627 aa)
	DNAL4	Dynein light chain. (105 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	ENSUAMP00000032533	Uncharacterized protein. (127 aa)
	ENSUAMP00000032535	Uncharacterized protein. (145 aa)
	NTRK3	Tyrosine-protein kinase receptor. (784 aa)
	EGR3	Early growth response 3. (387 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
	PTK6	Tyrosine-protein kinase. (482 aa)
	SRMS	Tyrosine-protein kinase. (492 aa)
	ENSUAMP00000034040	Uncharacterized protein. (92 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (507 aa)
	ENSUAMP00000035331	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (506 aa)
	ENSUAMP00000036314	Protein kinase domain-containing protein. (321 aa)
	ENSUAMP00000036324	Uncharacterized protein. (189 aa)
	VRK3	VRK serine/threonine kinase 3. (483 aa)
	ENSUAMP00000037274	Uncharacterized protein. (439 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	AP2A2	ENSUAMP00000010401	ENSUAMP00000020560	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.974
AP2A1	AP2B1	ENSUAMP00000010401	ENSUAMP00000010874	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit beta.	0.982
AP2A1	AP2M1	ENSUAMP00000010401	ENSUAMP00000006786	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
AP2A1	AP2S1	ENSUAMP00000010401	ENSUAMP00000021379	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Adaptor related protein complex 2 subunit sigma 1.	0.995
AP2A1	CLTA	ENSUAMP00000010401	ENSUAMP00000034671	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.981
AP2A1	DNAL4	ENSUAMP00000010401	ENSUAMP00000032040	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Dynein light chain.	0.449
AP2A1	ENSUAMP00000008294	ENSUAMP00000010401	ENSUAMP00000008294	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clat_adaptor_s domain-containing protein.	0.995
AP2A1	ENSUAMP00000011968	ENSUAMP00000010401	ENSUAMP00000011968	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.958
AP2A1	ENSUAMP00000011971	ENSUAMP00000010401	ENSUAMP00000011971	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Uncharacterized protein.	0.958
AP2A1	ENSUAMP00000031525	ENSUAMP00000010401	ENSUAMP00000031525	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Uncharacterized protein.	0.974
AP2A1	ENSUAMP00000036314	ENSUAMP00000010401	ENSUAMP00000036314	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Protein kinase domain-containing protein.	0.452
AP2A1	GRB2	ENSUAMP00000010401	ENSUAMP00000012687	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Growth factor receptor bound protein 2.	0.595
AP2A1	NGF	ENSUAMP00000010401	ENSUAMP00000031544	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Nerve growth factor; Belongs to the NGF-beta family.	0.537
AP2A1	NTRK1	ENSUAMP00000010401	ENSUAMP00000017240	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Tyrosine-protein kinase receptor.	0.532
AP2A1	SH3GL2	ENSUAMP00000010401	ENSUAMP00000003432	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	SH3 domain containing GRB2 like 2, endophilin A1.	0.617
AP2A2	AP2A1	ENSUAMP00000020560	ENSUAMP00000010401	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.974
AP2A2	AP2B1	ENSUAMP00000020560	ENSUAMP00000010874	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit beta.	0.995
AP2A2	AP2M1	ENSUAMP00000020560	ENSUAMP00000006786	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
AP2A2	AP2S1	ENSUAMP00000020560	ENSUAMP00000021379	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Adaptor related protein complex 2 subunit sigma 1.	0.994
AP2A2	CLTA	ENSUAMP00000020560	ENSUAMP00000034671	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.972