STRINGSTRING
IRX5 IRX5 STUB1 STUB1 ENSUAMP00000016017 ENSUAMP00000016017 ENSUAMP00000016192 ENSUAMP00000016192 TGFB3 TGFB3 TGFBR1 TGFBR1 TGIF2 TGIF2 SMURF2 SMURF2 ENSUAMP00000017561 ENSUAMP00000017561 WWTR1 WWTR1 CBL CBL HDAC1 HDAC1 PARP1 PARP1 SMAD4 SMAD4 ITGB1 ITGB1 TGFBR2 TGFBR2 MKX MKX SKIL SKIL E2F4 E2F4 PARD6A PARD6A KXD1 KXD1 ENSUAMP00000020628 ENSUAMP00000020628 RBL1 RBL1 FBN1 FBN1 RNF111 RNF111 TFDP1 TFDP1 MTMR4 MTMR4 ENSUAMP00000020715 ENSUAMP00000020715 TGFB2 TGFB2 ENSUAMP00000021443 ENSUAMP00000021443 CCNK CCNK BAMBI BAMBI IRX1 IRX1 ENSUAMP00000023048 ENSUAMP00000023048 ENSUAMP00000023083 ENSUAMP00000023083 SKI SKI ENSUAMP00000024123 ENSUAMP00000024123 TFDP2 TFDP2 E2F5 E2F5 ENSUAMP00000024424 ENSUAMP00000024424 ENSUAMP00000025086 ENSUAMP00000025086 ENSUAMP00000025159 ENSUAMP00000025159 LTBP1 LTBP1 ENSUAMP00000025192 ENSUAMP00000025192 ENSUAMP00000025215 ENSUAMP00000025215 NCOR1 NCOR1 ENSUAMP00000025261 ENSUAMP00000025261 PMEPA1 PMEPA1 ENSUAMP00000025971 ENSUAMP00000025971 MEIS3 MEIS3 ENSUAMP00000025995 ENSUAMP00000025995 FURIN FURIN SMAD3 SMAD3 SMAD2 SMAD2 IRX4 IRX4 LTBP3 LTBP3 PARD3B PARD3B CCNQ CCNQ ENSUAMP00000036704 ENSUAMP00000036704 ENSUAMP00000036703 ENSUAMP00000036703 ENSUAMP00000036702 ENSUAMP00000036702 ENSUAMP00000036253 ENSUAMP00000036253 CCNT1 CCNT1 UBE2D1 UBE2D1 CDK19 CDK19 ENSUAMP00000034195 ENSUAMP00000034195 IRX2 IRX2 F11R F11R ENSUAMP00000033004 ENSUAMP00000033004 CCNC CCNC NEDD8 NEDD8 MAPK3 MAPK3 NEDD4L NEDD4L NCOR2 NCOR2 ITGAV ITGAV ENSUAMP00000026981 ENSUAMP00000026981 SMAD7 SMAD7 ITGB6 ITGB6 SNW1 SNW1 ENSUAMP00000029127 ENSUAMP00000029127 USP9X USP9X CDK9 CDK9 IRX6 IRX6 ENSUAMP00000030007 ENSUAMP00000030007 ENSUAMP00000010232 ENSUAMP00000010232 ENSUAMP00000010402 ENSUAMP00000010402 ENSUAMP00000010405 ENSUAMP00000010405 PPM1A PPM1A ITGA8 ITGA8 TGFB1 TGFB1 PPP1R15A PPP1R15A MAPK1 MAPK1 CCNT2 CCNT2 ITGB5 ITGB5 STRAP STRAP ZFYVE9 ZFYVE9 ITGB8 ITGB8 ENSUAMP00000001764 ENSUAMP00000001764 LTBP2 LTBP2 ENSUAMP00000002663 ENSUAMP00000002663 LDLRAD4 LDLRAD4 ENSUAMP00000002926 ENSUAMP00000002926 ENSUAMP00000003968 ENSUAMP00000003968 ENSUAMP00000004097 ENSUAMP00000004097 ATP1B4 ATP1B4 SP1 SP1 LTBP4 LTBP4 MEN1 MEN1 IRX3 IRX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRX5Iroquois homeobox 5. (483 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
ENSUAMP00000016017PDZ domain-containing protein. (394 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
SMURF2E3 ubiquitin-protein ligase. (736 aa)
ENSUAMP00000017561Uncharacterized protein. (285 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
CBLCbl proto-oncogene. (796 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (975 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
MKXMohawk homeobox. (345 aa)
SKILSKI like proto-oncogene. (684 aa)
E2F4E2F transcription factor 4. (406 aa)
PARD6APar-6 family cell polarity regulator alpha. (348 aa)
KXD1KxDL motif containing 1. (128 aa)
ENSUAMP00000020628Par3_HAL_N_term domain-containing protein. (93 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
FBN1Fibrillin 1. (2348 aa)
RNF111Ring finger protein 111. (985 aa)
TFDP1Transcription factor Dp-1. (477 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
ENSUAMP00000020715Ubiquitin-like domain-containing protein. (132 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
ENSUAMP00000021443Ubiquitin-like domain-containing protein. (77 aa)
CCNKCyclin K; Belongs to the cyclin family. (353 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
IRX1Iroquois homeobox 1. (447 aa)
ENSUAMP00000023048PB1 domain-containing protein. (123 aa)
ENSUAMP00000023083Uncharacterized protein. (485 aa)
SKISKI proto-oncogene. (704 aa)
ENSUAMP00000024123Uncharacterized protein. (522 aa)
TFDP2Transcription factor. (360 aa)
E2F5E2F transcription factor 5. (350 aa)
ENSUAMP00000024424Uncharacterized protein. (1194 aa)
ENSUAMP00000025086Myosin_tail_1 domain-containing protein. (1195 aa)
ENSUAMP00000025159BZIP domain-containing protein. (314 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1554 aa)
ENSUAMP00000025192Ubiquitin-like domain-containing protein. (156 aa)
ENSUAMP00000025215BZIP domain-containing protein. (347 aa)
NCOR1Nuclear receptor corepressor 1. (2267 aa)
ENSUAMP00000025261GPS2_interact domain-containing protein. (204 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (237 aa)
ENSUAMP00000025971Peptidylprolyl isomerase. (143 aa)
MEIS3Meis homeobox 3. (315 aa)
ENSUAMP00000025995Uncharacterized protein. (52 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (793 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
IRX4Iroquois homeobox 4. (520 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1169 aa)
PARD3BPar-3 family cell polarity regulator beta. (821 aa)
CCNQCyclin Q; Belongs to the cyclin family. (250 aa)
ENSUAMP00000036704Uncharacterized protein. (132 aa)
ENSUAMP00000036703Protein kinase domain-containing protein. (185 aa)
ENSUAMP00000036702Protein kinase domain-containing protein. (154 aa)
ENSUAMP00000036253Protein kinase domain-containing protein. (66 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (726 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
CDK19Cyclin dependent kinase 19. (460 aa)
ENSUAMP00000034195Uncharacterized protein. (1577 aa)
IRX2Iroquois homeobox 2. (330 aa)
F11RF11 receptor. (298 aa)
ENSUAMP00000033004Peptidylprolyl isomerase. (105 aa)
CCNCCyclin C. (198 aa)
NEDD8NEDD8 ubiquitin like modifier. (81 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
NEDD4LE3 ubiquitin-protein ligase. (866 aa)
NCOR2Nuclear receptor corepressor 2. (2465 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
ENSUAMP00000026981Uncharacterized protein. (580 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
SNW1SNW domain containing 1. (511 aa)
ENSUAMP00000029127Homeobox domain-containing protein. (217 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2153 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
IRX6Iroquois homeobox 6. (493 aa)
ENSUAMP00000030007Uncharacterized protein. (124 aa)
ENSUAMP00000010232Ubiquitin-like domain-containing protein. (88 aa)
ENSUAMP00000010402BBC domain-containing protein. (492 aa)
ENSUAMP00000010405Uncharacterized protein. (120 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (901 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (756 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (733 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (621 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1422 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
ENSUAMP00000001764Uncharacterized protein. (55 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1805 aa)
ENSUAMP00000002663Homeobox domain-containing protein. (252 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (269 aa)
ENSUAMP00000002926Homeobox domain-containing protein. (89 aa)
ENSUAMP00000003968UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
ENSUAMP00000004097Uncharacterized protein. (245 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
SP1Sp1 transcription factor. (780 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1577 aa)
MEN1Menin 1. (610 aa)
IRX3Iroquois homeobox 3. (502 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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