STRINGSTRING
ENSUAMP00000036098 ENSUAMP00000036098 MCCC1 MCCC1 ENSUAMP00000011307 ENSUAMP00000011307 ENPP1 ENPP1 ENSUAMP00000011405 ENSUAMP00000011405 NAXD NAXD MTRR MTRR ENSUAMP00000012934 ENSUAMP00000012934 SLC25A19 SLC25A19 ACACB ACACB SHMT1 SHMT1 BTD BTD NT5E NT5E ENSUAMP00000013944 ENSUAMP00000013944 ENSUAMP00000014680 ENSUAMP00000014680 MMACHC MMACHC NMRK1 NMRK1 ENSUAMP00000014942 ENSUAMP00000014942 VNN1 VNN1 FAM162B FAM162B ENSUAMP00000015967 ENSUAMP00000015967 NAPRT NAPRT MROH6 MROH6 ENSUAMP00000016283 ENSUAMP00000016283 ENSUAMP00000016284 ENSUAMP00000016284 BST1 BST1 NAXE NAXE AIG1 AIG1 MOCOS MOCOS C1QTNF5 C1QTNF5 ENSUAMP00000018066 ENSUAMP00000018066 ENSUAMP00000018074 ENSUAMP00000018074 ENSUAMP00000018726 ENSUAMP00000018726 MTHFD1L MTHFD1L ENSUAMP00000019038 ENSUAMP00000019038 ZC3HAV1L ZC3HAV1L ZC3HAV1 ZC3HAV1 MACROD1 MACROD1 PTGS2 PTGS2 ENSUAMP00000019626 ENSUAMP00000019626 CCDC181 CCDC181 AOX1 AOX1 MTHFD2 MTHFD2 ENSUAMP00000020703 ENSUAMP00000020703 SLC25A47 SLC25A47 ENSUAMP00000020855 ENSUAMP00000020855 ENSUAMP00000021352 ENSUAMP00000021352 PARP16 PARP16 NNMT NNMT MINDY2 MINDY2 NMNAT1 NMNAT1 MMADHC MMADHC PNPO PNPO ENSUAMP00000022405 ENSUAMP00000022405 ENSUAMP00000022425 ENSUAMP00000022425 ENSUAMP00000022426 ENSUAMP00000022426 CYP8B1 CYP8B1 ENSUAMP00000022873 ENSUAMP00000022873 TIPARP TIPARP DCAKD DCAKD PARP8 PARP8 ENSUAMP00000023215 ENSUAMP00000023215 ENSUAMP00000023340 ENSUAMP00000023340 MTR MTR ENSUAMP00000023441 ENSUAMP00000023441 SLC46A1 SLC46A1 ENSUAMP00000023927 ENSUAMP00000023927 ENSUAMP00000023928 ENSUAMP00000023928 PPCDC PPCDC ENSUAMP00000024458 ENSUAMP00000024458 ALDH1L1 ALDH1L1 PCCA PCCA MTHFR MTHFR LRP2 LRP2 NMNAT2 NMNAT2 PDZD11 PDZD11 NADSYN1 NADSYN1 CDCP2 CDCP2 ENSUAMP00000025403 ENSUAMP00000025403 SLC46A3 SLC46A3 ENSUAMP00000025515 ENSUAMP00000025515 ADTRP ADTRP ENSUAMP00000026000 ENSUAMP00000026000 LMBRD1 LMBRD1 PTGIS PTGIS MMUT MMUT SHMT2 SHMT2 MOCS3 MOCS3 RFK RFK MTHFD1 MTHFD1 MOCS1 MOCS1 SLC52A3 SLC52A3 CD320 CD320 ENSUAMP00000029039 ENSUAMP00000029039 ENSUAMP00000029041 ENSUAMP00000029041 PARP9 PARP9 ENSUAMP00000029458 ENSUAMP00000029458 ENPP3 ENPP3 FPGS FPGS PANK3 PANK3 GDAP2 GDAP2 NADK NADK SLC23A2 SLC23A2 ENSUAMP00000032448 ENSUAMP00000032448 FASN FASN ENSUAMP00000032679 ENSUAMP00000032679 OVCA2 OVCA2 LDLRAP1 LDLRAP1 NUDT12 NUDT12 ENSUAMP00000034246 ENSUAMP00000034246 AMN AMN PANK4 PANK4 CYB5R3 CYB5R3 ENSUAMP00000034486 ENSUAMP00000034486 SLC23A1 SLC23A1 PDXK PDXK MOCS2 MOCS2 SLC25A16 SLC25A16 PANK2 PANK2 ENSUAMP00000035927 ENSUAMP00000035927 FOLR1 FOLR1 QPRT QPRT MINDY1 MINDY1 ENSUAMP00000036260 ENSUAMP00000036260 ENSUAMP00000036300 ENSUAMP00000036300 ENSUAMP00000036344 ENSUAMP00000036344 GPHN GPHN MMAB MMAB ENSUAMP00000036737 ENSUAMP00000036737 ENSUAMP00000037337 ENSUAMP00000037337 PC PC PPCS PPCS ENSUAMP00000010002 ENSUAMP00000010002 ENSUAMP00000010000 ENSUAMP00000010000 THTPA THTPA COASY COASY ANKRD16 ANKRD16 ENSUAMP00000008512 ENSUAMP00000008512 NAMPT NAMPT SLC5A6 SLC5A6 TCN2 TCN2 ENSUAMP00000007477 ENSUAMP00000007477 SLC52A1 SLC52A1 HLCS HLCS ENSUAMP00000006850 ENSUAMP00000006850 SLC22A14 SLC22A14 SLC22A13 SLC22A13 ENSUAMP00000006764 ENSUAMP00000006764 SLC19A3 SLC19A3 ABCC1 ABCC1 ENSUAMP00000006222 ENSUAMP00000006222 ENSUAMP00000005677 ENSUAMP00000005677 SLC5A8 SLC5A8 ENSUAMP00000004639 ENSUAMP00000004639 ENSUAMP00000004516 ENSUAMP00000004516 ENSUAMP00000004504 ENSUAMP00000004504 NEUROD6 NEUROD6 ENSUAMP00000003272 ENSUAMP00000003272 ENSUAMP00000003214 ENSUAMP00000003214 MMAA MMAA GSTO1 GSTO1 GSTO2 GSTO2 ENSUAMP00000002512 ENSUAMP00000002512 ENSUAMP00000002154 ENSUAMP00000002154 ENSUAMP00000001987 ENSUAMP00000001987 ENSUAMP00000001876 ENSUAMP00000001876 ENSUAMP00000001872 ENSUAMP00000001872 AASDHPPT AASDHPPT CBLIF CBLIF SLC2A1 SLC2A1 ENSUAMP00000000158 ENSUAMP00000000158 ENSUAMP00000000142 ENSUAMP00000000142 ACP5 ACP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000036098Folate_rec domain-containing protein. (232 aa)
MCCC1Methylcrotonoyl-CoA carboxylase 1. (543 aa)
ENSUAMP00000011307Uncharacterized protein. (1315 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (863 aa)
ENSUAMP00000011405Uncharacterized protein. (482 aa)
NAXDATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (329 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (723 aa)
ENSUAMP00000012934Aminotran_5 domain-containing protein. (457 aa)
SLC25A19Solute carrier family 25 member 19; Belongs to the mitochondrial carrier (TC 2.A.29) family. (326 aa)
ACACBAcetyl-CoA carboxylase beta. (2045 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
BTDBiotinidase. (523 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (528 aa)
ENSUAMP00000013944Uncharacterized protein. (1357 aa)
ENSUAMP00000014680ABC transmembrane type-1 domain-containing protein. (176 aa)
MMACHCMetabolism of cobalamin associated C. (282 aa)
NMRK1Nicotinamide riboside kinase 1. (202 aa)
ENSUAMP00000014942PAPS_reduct domain-containing protein. (127 aa)
VNN1Vanin 1. (483 aa)
FAM162BFamily with sequence similarity 162 member B. (163 aa)
ENSUAMP00000015967Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (258 aa)
NAPRTNicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (538 aa)
MROH6Maestro heat like repeat family member 6. (705 aa)
ENSUAMP00000016283THF_DHG_CYH_C domain-containing protein. (169 aa)
ENSUAMP00000016284THF_DHG_CYH domain-containing protein. (106 aa)
BST1Bone marrow stromal cell antigen 1. (312 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
AIG1Androgen induced 1. (144 aa)
MOCOSMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (791 aa)
C1QTNF5C1q and TNF related 5. (243 aa)
ENSUAMP00000018066MoCF_biosynth domain-containing protein. (325 aa)
ENSUAMP00000018074PAPS_reduct domain-containing protein. (179 aa)
ENSUAMP00000018726Uncharacterized protein. (386 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (961 aa)
ENSUAMP00000019038CoA carboxyltransferase N-terminal domain-containing protein. (294 aa)
ZC3HAV1LZinc finger CCCH-type containing, antiviral 1 like. (299 aa)
ZC3HAV1Poly [ADP-ribose] polymerase. (1023 aa)
MACROD1Mono-ADP ribosylhydrolase 1. (328 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
ENSUAMP00000019626Dynein light chain. (127 aa)
CCDC181Coiled-coil domain containing 181. (503 aa)
AOX1Aldehyde oxidase 1. (1332 aa)
MTHFD2Uncharacterized protein. (350 aa)
ENSUAMP00000020703TPK_catalytic domain-containing protein. (251 aa)
SLC25A47Solute carrier family 25 member 47; Belongs to the mitochondrial carrier (TC 2.A.29) family. (306 aa)
ENSUAMP00000020855Uncharacterized protein. (512 aa)
ENSUAMP00000021352Uncharacterized protein. (141 aa)
PARP16Poly [ADP-ribose] polymerase. (323 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
MINDY2MINDY lysine 48 deubiquitinase 2. (598 aa)
NMNAT1Nicotinamide-nucleotide adenylyltransferase. (280 aa)
MMADHCMetabolism of cobalamin associated D. (289 aa)
PNPOPyridoxamine 5'-phosphate oxidase. (261 aa)
ENSUAMP00000022405Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
ENSUAMP00000022425Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (254 aa)
ENSUAMP00000022426Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (243 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
ENSUAMP00000022873Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (657 aa)
DCAKDDephospho-CoA kinase domain containing. (231 aa)
PARP8Poly [ADP-ribose] polymerase. (515 aa)
ENSUAMP00000023215Uncharacterized protein. (59 aa)
ENSUAMP00000023340DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1178 aa)
ENSUAMP00000023441DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
SLC46A1Solute carrier family 46 member 1. (459 aa)
ENSUAMP00000023927Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (203 aa)
ENSUAMP00000023928Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
PPCDCPhosphopantothenoylcysteine decarboxylase. (204 aa)
ENSUAMP00000024458Uncharacterized protein. (155 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (930 aa)
PCCAPropionyl-CoA carboxylase subunit alpha. (573 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (654 aa)
LRP2LDL receptor related protein 2. (4684 aa)
NMNAT2Nicotinamide nucleotide adenylyltransferase 2. (307 aa)
PDZD11PDZ domain containing 11. (140 aa)
NADSYN1Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (723 aa)
CDCP2CUB domain containing protein 2. (411 aa)
ENSUAMP00000025403Cytochrome b5 heme-binding domain-containing protein. (107 aa)
SLC46A3Solute carrier family 46 member 3. (461 aa)
ENSUAMP00000025515THF_DHG_CYH domain-containing protein. (106 aa)
ADTRPAndrogen dependent TFPI regulating protein. (246 aa)
ENSUAMP00000026000Uncharacterized protein. (224 aa)
LMBRD1LMBR1 domain containing 1. (398 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (499 aa)
MMUTMethylmalonyl-CoA mutase. (750 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
MOCS3Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (458 aa)
RFKRiboflavin kinase. (155 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (992 aa)
MOCS1Molybdenum cofactor synthesis 1. (633 aa)
SLC52A3Solute carrier family 52 member 3. (469 aa)
CD320CD320 molecule. (258 aa)
ENSUAMP00000029039CTP_transf_like domain-containing protein. (180 aa)
ENSUAMP00000029041CTP_transf_like domain-containing protein. (61 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (827 aa)
ENSUAMP00000029458Poly [ADP-ribose] polymerase. (359 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (868 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (579 aa)
PANK3Pantothenate kinase 3. (368 aa)
GDAP2Ganglioside induced differentiation associated protein 2. (495 aa)
NADKNAD kinase. (496 aa)
SLC23A2Solute carrier family 23 member 2. (650 aa)
ENSUAMP000000324485-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (203 aa)
FASNFatty acid synthase. (2519 aa)
ENSUAMP00000032679CoA carboxyltransferase N-terminal domain-containing protein. (212 aa)
OVCA2OVCA2 serine hydrolase domain containing. (227 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (309 aa)
NUDT12Nudix hydrolase 12. (462 aa)
ENSUAMP00000034246Uncharacterized protein. (184 aa)
AMNAmnion associated transmembrane protein. (461 aa)
PANK44'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. (789 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa)
ENSUAMP00000034486Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (96 aa)
SLC23A1Solute carrier family 23 member 1. (656 aa)
PDXKPyridoxal kinase. (312 aa)
MOCS2Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. (193 aa)
SLC25A16Solute carrier family 25 member 16; Belongs to the mitochondrial carrier (TC 2.A.29) family. (330 aa)
PANK2Pantothenate kinase 2. (451 aa)
ENSUAMP00000035927Poly [ADP-ribose] polymerase. (1173 aa)
FOLR1Folate receptor alpha. (254 aa)
QPRTQuinolinate phosphoribosyltransferase. (324 aa)
MINDY1MINDY lysine 48 deubiquitinase 1. (465 aa)
ENSUAMP00000036260Uncharacterized protein. (1033 aa)
ENSUAMP00000036300Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (139 aa)
ENSUAMP00000036344Folate_rec domain-containing protein. (253 aa)
GPHNGephyrin. (800 aa)
MMABCorrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (239 aa)
ENSUAMP00000036737Uncharacterized protein. (322 aa)
ENSUAMP00000037337Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (143 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1190 aa)
PPCSPhosphopantothenoylcysteine synthetase. (310 aa)
ENSUAMP00000010002Uncharacterized protein. (220 aa)
ENSUAMP00000010000Uncharacterized protein. (245 aa)
THTPAThiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). (230 aa)
COASYCoenzyme A synthase. (560 aa)
ANKRD16Ankyrin repeat domain 16. (363 aa)
ENSUAMP00000008512Biotin carboxylation domain-containing protein. (206 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (505 aa)
SLC5A6Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (638 aa)
TCN2Transcobalamin 2. (430 aa)
ENSUAMP00000007477Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (253 aa)
SLC52A1Uncharacterized protein. (445 aa)
HLCSHolocarboxylase synthetase. (670 aa)
ENSUAMP00000006850Uncharacterized protein. (490 aa)
SLC22A14Solute carrier family 22 member 14. (600 aa)
SLC22A13Solute carrier family 22 member 13. (551 aa)
ENSUAMP00000006764Uncharacterized protein. (494 aa)
SLC19A3Solute carrier family 19 member 3. (506 aa)
ABCC1ATP binding cassette subfamily C member 1. (1415 aa)
ENSUAMP00000006222Carrier domain-containing protein. (376 aa)
ENSUAMP00000005677Aldedh domain-containing protein. (169 aa)
SLC5A8Solute carrier family 5 member 8; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (611 aa)
ENSUAMP00000004639Uncharacterized protein. (58 aa)
ENSUAMP00000004516Uncharacterized protein. (287 aa)
ENSUAMP00000004504Poly [ADP-ribose] polymerase. (382 aa)
NEUROD6Neurogenic differentiation factor. (337 aa)
ENSUAMP00000003272SHMT domain-containing protein. (59 aa)
ENSUAMP00000003214Uncharacterized protein. (116 aa)
MMAAMetabolism of cobalamin associated A. (420 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (278 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
ENSUAMP00000002512Uncharacterized protein. (197 aa)
ENSUAMP00000002154Amino_oxidase domain-containing protein. (235 aa)
ENSUAMP00000001987Peptidase S1 domain-containing protein. (155 aa)
ENSUAMP00000001876Uncharacterized protein. (2013 aa)
ENSUAMP00000001872Dynein light chain. (124 aa)
AASDHPPTAminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa)
CBLIFCobalamin binding intrinsic factor. (409 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ENSUAMP00000000158Uncharacterized protein. (70 aa)
ENSUAMP00000000142Uncharacterized protein. (159 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (335 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (36%) [HD]